Preparation and characterization of a novel pachyman-based pharmaceutical aid. II: A pH-sensitive, biodegradable and biocompatible hydrogel for controlled release of protein drugs

Xiao, Yuling; Xu, Wenjin; Zhu, Qifeng; Yan, Bingfang; Yang, Dongfang; Yang, Jin; He, Xu; Liang, Shucai; Hu, Xianming

doi:10.1016/j.carbpol.2009.02.003

Cited by 25 publications

(8 citation statements)

References 40 publications

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“…It is reported that such changes are predominantly at the boundary surface of nanoparticles. 7,49,50 A reduction in negative ellipticity, which followed the order glu > ele > edc is an indication of the extent of perturbation brought about by the crosslinker on the protein. In this work, though a direct measure of the quantum of protein at the protein-nanostructure interface was not available, zeta potential measurements, [discussed in the later part of the study] are indicative of the free protein surrounding the nanostructures.…”

Section: Conjugation/absorptioninduced Bsa Conformational Changes: Ci...mentioning

confidence: 99%

BSA binding to silica capped gold nanostructures: effect of surface cap and conjugation design on nanostructure–BSA interface

et al. 2014

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This paper presents a detailed and systematic study of amine functionalization of silica coating of gold nanostructures and the electrostatic and covalent binding of the prepared silica capped gold nanostructures to BSA. The involvement of a Tryptophan residue in the hydrophobic pocket of BSA and its interaction with nanostructures was established. Fluorescence studies of tryptophan residues of the protein molecules after conjugation revealed that the method of crosslinking did not bring about major changes to the binding constant (10 12 M À1 ) of BSA to nanostructures. Electrostatic binding indicated a larger number of binding sites (2.56) on the protein. Nanoparticle binding brought about a reduction in the characteristic negative ellipticity of BSA, indicating a change in the helical content. The reduction in the elliptical path of BSA was influenced by both nanoparticle curvature and crosslinker, such as in the case of glutaraldehyde or by the nanoparticle curvature alone as in the case of zero length crosslinker -EDC-NHS. Though not a subject matter of this study, the results obtained in this study could have implications in the design of nanobiomaterials, biosafety concerns and their cellular responses.

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Section: Conjugation/absorptioninduced Bsa Conformational Changes: Ci...mentioning

confidence: 99%

BSA binding to silica capped gold nanostructures: effect of surface cap and conjugation design on nanostructure–BSA interface

et al. 2014

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“…In the case of constrained swelling, where the gel is coated by a semi-permeable membrane and immersed in water, we compute the radial stress-radial stretch relationship for the case of an incompressible Neo-Hookean thin shell, 30 deriving the stress-stretch relationship from the incompressible simplification of eqn (5). This leads, using eqn (11) and only on the boundary, to:…”

Section: Boundary Conditionsmentioning

confidence: 99%

Swelling kinetics of constrained hydrogel spheres

Cano,

Na,

Sun

et al. 2023

Soft Matter

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“…Therefore, the disintegrating properties of pachyman, CMP and hydroxypropyl pachyman(HPP) have been evaluated as disintegrants in ampicillin and probenecid dispersible tablets [13] . Hydrogels based on pachyman, CMP and hydroxyethyl pachyman(HEP) have also been fabricated and proved to be promising delivery carriers for protein drugs [14,15] . In addition, self-assembled nanoparticles (NPs) of deoxycholic acid -modifi ed CMP conjugate have been prepared and characterized by Hu et al [16] , but the drug loading and release properties have not been given.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation in vitro of salicylic acid-pachyman nanoparticles

Zhang

Shao

Xiao

et al. 2011

J. Wuhan Univ. Technol.-Mat. Sci. Edit.

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Pachyman based nanoparticles loading salicylic acid as model drug (SA-PNPs) were prepared by an inverse microemulsion crosslinking approach using epichlorohydrin (ECH) as crosslinker. The effects of crosslinking reaction time, initial volume ratio of oil to aqueous phase and dosage of crosslinker on the particle size of SA-PNPs were optimized by orthogonal experimental design. SA-PNPs prepared under the optimal conditions had the average size of 230 nm and high encapsulation effi ciency of 90%. The in vitro drug release was also investigated and the release data were analyzed using zero order, fi rst order and Higuchi's kinetics model. According to the determined coeffi cients, release data fi tted to Higuchi's model, which suggested that the release of SA from SA-PNPs in phosphate buffer (pH 7.4) was diffusion controlled release. The experimental results indicated that pachyman possesses a promising potential to be applied as nanocarriers for controlled drug release.

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Preparation and characterization of a novel pachyman-based pharmaceutical aid. II: A pH-sensitive, biodegradable and biocompatible hydrogel for controlled release of protein drugs

Cited by 25 publications

References 40 publications

BSA binding to silica capped gold nanostructures: effect of surface cap and conjugation design on nanostructure–BSA interface

BSA binding to silica capped gold nanostructures: effect of surface cap and conjugation design on nanostructure–BSA interface

Swelling kinetics of constrained hydrogel spheres

Preparation and evaluation in vitro of salicylic acid-pachyman nanoparticles

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