Preparation and characterization of a novel Astragalus membranaceus polysaccharide-iron (III) complex

Lü, Qi; Xu, Lei; Meng, Yongbin; Liu, Ying; Li, Jian; Zu, Yuangang; Zhu, Minghua

doi:10.1016/j.ijbiomac.2016.08.049

Cited by 54 publications

(56 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, sodium citrate was available for further reaction to get more AOS–iron (III). However, an excessive amount of sodium citrate led to decreased pH of the solution (Lu et al ., ), resulting in decreased iron content (Fig. e).…”

Section: Resultsmentioning

confidence: 95%

See 1 more Smart Citation

Preparation and characterisation of a novel agar oligosaccharide–iron (III) complex

Teng

et al. 2018

Int J of Food Sci Tech

View full text Add to dashboard Cite

This study aimed to synthesise a complex of agar oligosaccharides (AOS) with ferric iron and to evaluate its physicochemical and structural characteristics. Based on single factor, Plackett-Burman and response surface optimal experiments of three factors at three levels, the optimised chelate conditions of the AOSiron (III) complex were mass ratio of AOS to iron ions of 4.5:1 g:g, reaction temperature of 74°C and reaction time of 60 min. Under these conditions, the iron content and total sugar content were 14.03 AE 0.42% and 66.07 AE 0.96%, respectively. The physicochemical analysis showed that AOS-iron (III) was soluble and steady at physiological pH, and it was easily reduced to iron (II). The structural characteristics of AOS and AOS-iron (III) were analysed by Raman spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction and Nuclear magnetic resonance, and results showed that the iron (III) ions were chelated to AOS by -OH groups and -COOH groups and widely dispersed on the AOS backbone. Therefore, AOS-iron (III) could be a candidate for iron supplementation to treat iron deficiency anaemia.

show abstract

Section: Resultsmentioning

confidence: 95%

“…As shown in Table , AOS–iron (III) has a higher molecular weight and lower total sugar content compared with that of AOS. The difference in molecular weight and total sugar contents between AOS and AOS–iron (III) was due to the presence of 14.03% iron in the AOS–iron (III) (Lu et al ., ).…”

Section: Resultsmentioning

confidence: 97%

Preparation and characterisation of a novel agar oligosaccharide–iron (III) complex

Teng

et al. 2018

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…The results indicated that dual‐frequency sonication had positive effects on the scavenging capacity of the APS against the DPPH radical. In an earlier study, APS that was synthesized with iron chloride hexahydrate was observed to have considerable scavenging properties on the DPPH radical (Lu et al, ). In another study, APS extracted using the reflux and hot water method did not have sizeable effects on lowering oxidation against the DPPH radical compared to the enzyme‐treated extracts (Chen et al, ; Pu et al, ).…”

Section: Resultsmentioning

confidence: 99%

Dual‐frequency ultrasound‐assisted alcohol/salt aqueous two‐phase extraction and purification of Astragalus polysaccharides

Chikari

Han

Wang

et al. 2020

J Food Process Engineering

View full text Add to dashboard Cite

The study investigated the effect of dual‐frequency ultrasound‐assisted alcohol/salt aqueous two‐phase extraction and desalination on the yield, microstructure and antioxidant properties of Astragalus polysaccharides (APS). Extracts were desalinated for 10 (APS10), 20 (APS20), and 30 (APS30) minutes. A 28.40% experimental yield, well correlated to the response surface methodology predicted model was achieved. Thermodynamic parameters were non‐spontaneous, irreversible and endothermic. Moreover, ultrasound enhanced the desalination rate and did not alter the chemical structure in the APS. Fourier Transform Infrared Spectroscopy showed a similar spectrum in all the APS samples. High‐performance gel chromatography and scanning electron microscopy, respectively presented reduced molecular weights and altered microstructures in the samples. Monosaccharide analysis revealed the existence of xylose, mannose, galactose, glucose, arabinose, rhamnose, and ribose in the APS samples. Moreover, the APS20 showed strong hydroxyl and 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging activities, thus showing its potency in reducing oxidative stress. Hence, this study demonstrates that coupled ultrasound and alcohol/salt ATPS is a sustainable technique, which generates high yields of simultaneously extracted products. Practical applications Astragalus root has been used as an effective complementary treatment to conventional medicine owing to its rich nutraceutical composition and its numerous health attributes. Commercialization of Astragalus supplements into functional foods and nutraceuticals requires continuous exploration of novel, low cost and reproducible methods that retain their bioactivity. In this work, a synergized and bio‐compatible dual‐frequency ultrasound‐assisted alcohol/salt aqueous two‐phase system was used to extract and purify Astragalus polysaccharides. Application of this technique in the nutraceutical industry reduces treatment time, lowers bulk energy consumption hence reducing energy costs. It promotes the use of low‐cost, non‐hazardous bio‐based solvents in treatment processes thus considerably reducing extraction costs and environmental degradation. Findings from this study exhibit the practicability of this technique in industrial application. It equips biotechnologists with information on improved, sustainable and safer ways of extracting and enriching the quality of nutraceutical compounds.

show abstract

“…Traditional Chinese medicine indications for A. membranaceus focus on “qi deficiency,” and patients often feel anorexia, a lack of strength, spontaneous sweating. Chemical extraction analysis shows that A. membranaceus contain many active components, such as astragalosides I–VIII, flavonoids, polysaccharides, amino acids and trace elements (Liu et al, 2013 ; Lu et al, 2016 ). Several clinical studies and animal experiments have confirmed that the effective components of A. membranaceus can enhance immune function and have anti-tumor effect (Cho and Leung, 2007 ; Huang et al, 2013 ; He et al, 2016 ; Li J. et al, 2016 ).…”

Section: Single Herbal Medicines For Dsmmentioning

confidence: 99%

Recent Advances in Herbal Medicines for Digestive System Malignancies

et al. 2018

View full text Add to dashboard Cite

Herbal medicines, as an important part of traditional Chinese medicine (TCM), have been used to treat digestive system malignancies (DSM) for many years, and have gradually gained recognition worldwide. The role of herbal medicines in the comprehensive treatment of DSM is being improved from adjuvant treatment of the autologous immune function in cancer patients, to the treatment of both the symptoms and disease, direct inhibition of tumor cell growth and proliferation, and induction of tumor cell autophagy and apoptosis. Their specific mechanisms in these treatments are also being explored. The paper reviews the current anti-tumor mechanisms of TCM, including single herbal medicines, Chinese herbal formulations, Chinese medicine preparations and TCM extract, and their application in the comprehensive treatment of digestive system tumors, providing a reference for clinical application of TCM.

show abstract

Preparation and characterization of a novel Astragalus membranaceus polysaccharide-iron (III) complex

Cited by 54 publications

References 42 publications

Preparation and characterisation of a novel agar oligosaccharide–iron (III) complex

Preparation and characterisation of a novel agar oligosaccharide–iron (III) complex

Dual‐frequency ultrasound‐assisted alcohol/salt aqueous two‐phase extraction and purification of Astragalus polysaccharides

Recent Advances in Herbal Medicines for Digestive System Malignancies

Contact Info

Product

Resources

About