Preparation and characterization of a three dimensional porous poly(lactic-co-glycolic acid)/mesoporous silica nanoparticles scaffold by low-temperature deposition manufacturing

Cai, Gaorui; Zhu, Fuliang; Liu, Wei; Zhu, Tianfei; Li, Duan; Tan, Hui; Pan, Jing; Xiong, Jianyi; Wang, Daping

doi:10.1016/j.mtcomm.2020.101824

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Phase separation and freeze drying ◆ High porosity ◆ Difficult control of porous structure ◆ Limited pore size range PCL/Chitosan/Gel [201] Pore size (5-73 µm), porosity (≈79%) Compressive strength:≈2.5 MPa, compressive modulus:≈3.8 MPa PLGA/mesoporous silica nanoparticles (MSNs) [182] Big pore (431 µm), small pore (5.6 µm), porosity (85.9%) Compressive modulus:≈25.9 MPa Gelatin/biodegradable poly (glycerol-co-sebacic acid-co-L-lactic acid-co-polyethylene glycol) (PGSLP) [202] Porosity (68.93%) Compressive modulus: 120.67 kPa…”

Section: Not Mentionedmentioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

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It is an urgent need that defect repair can develop from simple device fixation to living tissue reconstruction, from short life function replacement to permanent regeneration repair. At present, bone transplantation has become the second largest transplantation surgery after blood transfusion, and artificial bone transplantation generates great hope for the repair and treatment of bone defect. In order to repair bone defect, artificial bone must have good biological properties and sufficient mechanical properties, and it should also have the shape matching to bone defect site and the connected porous structure. For structures and properties requirements of artificial bone, in this review three major challenges faced by artificial bone transplantation are systemtically analyzed and current methods and strategies to address these issues are discussed: 1) the need for developing a type of bone scaffold material with both biological and mechanical properties, 2) the need for realizing the controllable fabrication of individual shape and multistage pore structure of bone scaffold, 3) the need for realizing the transformation from man‐made structure to biological structure. Besides, it summarizes the advantages and disadvantages of these methods and discusses the potential future directions of structural and functional adaptive artificial bone for bone defect regeneration.

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Section: Not Mentionedmentioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

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“…The absorption band around at 869 cm −1 was attributed to -C-H bending vibrations [56]. The absorption peaks at 1080 and 1165 cm −1 were assigned to stretching vibration of -C-O and asymmetrical stretching of C-O-C ether group [42,[57][58][59]. The peak at 1045 cm −1 was corresponding to -OH bending in -CH(CH3)-OH end groups [60].…”

Section: Ftir Analysismentioning

confidence: 99%

“…An appropriate surface hydrophilicity promotes cell adhesion and proliferation on the scaffolds [57,58]. The water contact angle of experimental groups was calculated to assess whether the addition of CNT increased the hydrophilicity of the PLGA and PLGA/HA.…”

Section: Water Contact Angle Measurementmentioning

confidence: 99%

CNT incorporation improves the resolution and stability of porous 3D printed PLGA/HA/CNT scaffolds for bone regeneration

Kaya,

Arıcı,

Bulut

et al. 2023

Biomed. Mater.

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In this study, 3D printed porous poly(lactide-co-glycolide) (PLGA) and its nanocomposites with 5 wt. % hydroxyapatite (HA) and 0.5, 1 and 2 wt. % multi-walled carbon nanotubes (MWCNT) scaffolds were fabricated by using extrusion-based printing. The printing parameters were optimized by rheological studies. The rheological studies demonstrated shear thinning properties for all compositions and an increase in storage modulus was observed after the addition of MWCNT. Porous PLGA/HA/MWCNT scaffolds were printed by applying a pressure of 4.76 bar at 125 ⁰C. The addition of 0.5 wt. % of MWCNT reduced the strut size and increased the porosity from 42% to 60%. The increase of storage modulus and decrease of strut size was related to hydrogen bonding between MWCNT, HA and PLGA which ultimately improved shape fidelity. The scaffolds were characterized by analysis of their chemical structure, water contact angle measurement, in vitro bioactivity test, biodegradation test, mechanical analysis, and in vitro cell studies. The scaffolds were found to be more hydrophilic by the incorporation of MWCNTs. Also, degradation studies showed that the microstructure of the scaffold became more stable with the addition of HA and MWCNT. The compressive modulus of PLGA/HA/CNT2 scaffold was found to be 548.5 MPa which is found suitable to replace cancellous bone. The scaffolds were found highly biocompatible which is possibly due to alignment of MWCNT and PLGA during 3D printing process. Alizarin red staining indicated improvement of mineralization of MC3T3-E1 cells on the MWCNT incorporated porous 3D scaffolds. The results suggest that the produced porous 3D printed PLGA/HA/MWCNT scaffolds are promising for bone regeneration applications.

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Optical Properties of One Pot Synthesized Porous, Monodisperse, Size-Controlled Silica Particles: Effect of Tetra Alkoxysilane Addition Rate

Saini,

Negi,

Srivastava

et al. 2024

Silicon

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Preparation and characterization of a three dimensional porous poly(lactic-co-glycolic acid)/mesoporous silica nanoparticles scaffold by low-temperature deposition manufacturing

Cited by 4 publications

References 43 publications

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

CNT incorporation improves the resolution and stability of porous 3D printed PLGA/HA/CNT scaffolds for bone regeneration

Optical Properties of One Pot Synthesized Porous, Monodisperse, Size-Controlled Silica Particles: Effect of Tetra Alkoxysilane Addition Rate

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