Preparation and characterization of a dual cross-linking injectable hydrogel based on sodium alginate and chitosan quaternary ammonium salt

Geng, Zhijie; Ji, Yuxing; Yu, Shan Ping; Liu, Qunfeng; Zhou, Zongbao; Guo, Cuiping; Lu, Daohuan; Pei, Dating

doi:10.1016/j.carres.2021.108389

Cited by 51 publications

(30 citation statements)

References 31 publications

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“…Hydrogel is a porous material with a 3D network structure, which is composed of cross-linked hydrophilic polymer chains and can absorb and retain large amounts of liquid media [1]. In 1960, hydrogels were made for the first time using 1,2-ethanediol dimethacrylate and glycol methacrylate.…”

Section: Introductionmentioning

confidence: 99%

The Study of the Swelling Degree of the PVA Hydrogel with varying concentrations of PVA

Asy-Syifa

Kusjuriansah

Waresindo

et al. 2022

J. Phys.: Conf. Ser.

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Hydrogel is composed of a three-dimensional network of hydrophilic polymers and can swell when placed in an aqueous media. Polyvinyl alcohol (PVA) is a common polymer used to produce hydrogels because it has biocompatibility, non-toxicity, chemical stability, low cost, and excellent mechanical strength. In this study, the PVA solutions were prepared with concentrations of 6%, 8%, 10%, and 12% in distilled water. The precursor solutions underwent a freeze-thaw cycle with a freezing temperature of -25 °C for 20 hours and a thawing temperature of 37 °C for 4 hours and carried out for 6 cycles. The swelling degree and the gel fraction of the hydrogel were then determined. From the swelling degree results, the increase of the PVA concentration in the precursor solutions reduced the swelling degree of the hydrogel. Based on the gel fraction test, it was revealed that all PVA concentrations have approximately the same value of gel fraction at 97%. Additionally, the viscosity and the density were also measured. Both showed an increasing trend with the addition of PVA concentration, where the viscosity values from the smallest to highest concentrations were 12.4944, 34.1737, 93.8491, and 216.2979 cP while the density values were 0.9865, 0.9871, 0.9878, and 0.9885 gram.cm-3.

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Section: Introductionmentioning

confidence: 99%

The Study of the Swelling Degree of the PVA Hydrogel with varying concentrations of PVA

Asy-Syifa

Kusjuriansah

Waresindo

et al. 2022

J. Phys.: Conf. Ser.

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“…The dynamic covalent boronate ester bonds and ionic gelation in presence of divalent cations allowed a modular crosslinking with suitable rheological and mechanical properties for biomimetic 3D scaffolds. Injectable DN hydrogels were prepared from CS quaternary ammonium salt and Alg-Na by electrostatic interaction and ionic crosslinking [225]. The hydrogels presented good biocompatibility and appropriate mechanical properties for potential applications as injectable hydrogels for nerve or cardiac reparation.…”

Section: Alginatementioning

confidence: 99%

“…Polymers 2022, 14, 2365 21 of 42 electrostatic interaction and ionic crosslinking [225]. The hydrogels presented good biocompatibility and appropriate mechanical properties for potential applications as injectable hydrogels for nerve or cardiac reparation.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities

Bercea¹

2022

Polymers

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Hydrogels, as interconnected networks (polymer mesh; physically, chemically, or dynamic crosslinked networks) incorporating a high amount of water, present structural characteristics similar to soft natural tissue. They enable the diffusion of different molecules (ions, drugs, and grow factors) and have the ability to take over the action of external factors. Their nature provides a wide variety of raw materials and inspiration for functional soft matter obtained by complex mechanisms and hierarchical self-assembly. Over the last decade, many studies focused on developing innovative and high-performance materials, with new or improved functions, by mimicking biological structures at different length scales. Hydrogels with natural or synthetic origin can be engineered as bulk materials, micro- or nanoparticles, patches, membranes, supramolecular pathways, bio-inks, etc. The specific features of hydrogels make them suitable for a wide variety of applications, including tissue engineering scaffolds (repair/regeneration), wound healing, drug delivery carriers, bio-inks, soft robotics, sensors, actuators, catalysis, food safety, and hygiene products. This review is focused on recent advances in the field of bioinspired hydrogels that can serve as platforms for life-science applications. A brief outlook on the actual trends and future directions is also presented.

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“…It facilitated the proliferation of the encapsulated neural progenitor cells. Furthermore, Geng et al [14] developed a dual cross‐linking injectable hydrogel from alginate. It can be formed by the electrostatic interaction between molecules.…”

Section: Introductionmentioning

confidence: 99%

Release Characteristic and Antioxidant Activity of 4‐Hydroxybenzoic Acid (4HB) from Sodium Alginate and Polyvinyl Alcohol‐based Hydrogel

et al. 2022

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1, 3 and 5 %wt of 4‐hydroxybenzoic acid (4HB) was successfully loaded into sodium alginate and polyvinyl alcohol‐based hydrogel composite for enhancement of antioxidant activities. Hydrogel was prepared by freeze thaw technique. No crosslinking agents were employed. Fourier transform infrared and X‐ray diffraction technique revealed that no significant change of functional group and crystallinity was observed when 4HB was loaded. By using freeze thaw technique, microstructural properties were well packed as reported by scanning electron microscope. Due to small amount of 4‐hydroxybenzoic acid, thermal characteristic was presented in the similar feature compare to pristine hydrogel. Differential scanning calorimetry exhibited that the glass transition and melting temperatures were reported to be 90 °C and 225 °C, respectively. However, tensile strength was slightly reduced by loading 4HB. The swelling behavior was very rapidly increased at the initial stage and then it was stable. Antioxidant activities were observed by means of DPPH assay. It was important to note that 4HB loaded into sodium alginate and polyvinyl alcohol‐based hydrogel exhibited outstanding properties to be candidate as food additives to help prevent food deterioration.

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Preparation and characterization of a dual cross-linking injectable hydrogel based on sodium alginate and chitosan quaternary ammonium salt

Cited by 51 publications

References 31 publications

The Study of the Swelling Degree of the PVA Hydrogel with varying concentrations of PVA

The Study of the Swelling Degree of the PVA Hydrogel with varying concentrations of PVA

Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities

Release Characteristic and Antioxidant Activity of 4‐Hydroxybenzoic Acid (4HB) from Sodium Alginate and Polyvinyl Alcohol‐based Hydrogel

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