Preparation and characterization of a chiral molecularly imprinted polymer with a novel functional monomer for controlled release of S-sulpiride

Wang, Liping; She, Xuhui; Chen, Zhi; Quan, Sisi; Liu, Yingtao; Mai, Xiaoman; Yuan, Tiefeng; Fan, Huajun

doi:10.1016/j.ijpharm.2021.120526

Cited by 18 publications

(12 citation statements)

References 26 publications

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“…In contrast, only one group of values of K d and Q max of S‐NIP/NIP being on behalf of the lower affinity were attained, and they were, respectively, 0.2776/0.9709 mg ml −1 and 220.91/460.65 mg g −1 . It was worth noting that the low affinity in SMIP/SMIP should be caused by the nonspecific structure such as hydrogen bond, hydrophobic group and so on, which was also consistent with that in S‐NIP/NIP, and the high affinity in S‐SMIP (SMIP) to SOR should be attributed to the specific binding sites based on the imprinted cavity 42 …”

Section: Resultssupporting

confidence: 58%

“…41 Surely, the above results were also consistent with the data of zeta potential as shown in such as hydrogen bond, hydrophobic group and so on, which was also consistent with that in S-NIP/NIP, and the high affinity in S-SMIP (SMIP) to SOR should be attributed to the specific binding sites based on the imprinted cavity. 42 The Scatchard equation was shown as follows:…”

Section: Isothermal Adsorptionmentioning

confidence: 99%

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A novel smart stealth sorafenib delivery system based on the magnetic imprinting material modified by polyethylene glycol

Wang

Bao

Tan

et al. 2023

Polymers for Advanced Techs

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In order to improve the solubility and the long-cycle performance of hydrophobic drug sorafenib (SOR), and to obtain an ideal smart drug delivery system for the effective treatment of liver cancer, S-SMIP, a pH/GSH double-sensitive sorafenib stealth imprinting material, was successfully prepared by UV-initiated surface imprinted polymerization on the basis of polyethylene glycol 2000 (PEG 2000 ) acted as "gate keeper" modified magnetic substrate. The results showed that S-SMIP had a good adsorption capacity of 260.0 mg g À1 and an excellent selectivity factor α 2.33. S-SMIP's kinetic adsorption data accorded well with the pseudo-second-order model and its mechanism was controlled mainly by chemical adsorption. The drug release experiments in vitro indicated S-SMIP could not only greatly improve the solubility of SOR, but also had the pH/GSH dual-sensitive response performance. Compared with the non-stealth imprinted material SMIP, S-SMIP still had a better long-cycle effect on the release of SOR, increasing to160 h from 130 h. So, the target material S-SMIP could greatly prolong the half-life of SOR, which provided a good idea for the development of a smart drug delivery system.

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Section: Resultssupporting

confidence: 58%

Section: Isothermal Adsorptionmentioning

confidence: 99%

A novel smart stealth sorafenib delivery system based on the magnetic imprinting material modified by polyethylene glycol

Wang

Bao

Tan

et al. 2023

Polymers for Advanced Techs

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“…As a simple and practical method to study the interaction between molecules, UV-vis spectroscopy was used to explore the interaction between template molecules and functional monomers [33]. Here, we used dimethoate as template and silanization reagent as functional monomer.…”

Section: Selection Of Functional Monomersmentioning

confidence: 99%

Rapid Detection of Dimethoate in Soybean Samples by Microfluidic Paper Chips Based on Oil-Soluble CdSe Quantum Dots

Yan

Zhang

et al. 2021

Foods

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Given the imperative of monitoring organophosphorus pesticides (OPs) residues in the ecosystem, here a novel, facile and sensitive fluorescence sensor is presented for the rapid detection of dimethoate. In this work, surface molecularly imprinted polymer (SMIP) and microfluidic technology had been introduced to enhance the selectivity and portability of the described methodology. Oil-soluble CdSe quantum dots (QDs) synthesized in a green way were used as fluorescent material for the selective detection of dimethoate on the basis of static quenching and photoinduced electron transfer mechanism. Among many kinds of paper materials, glass fiber paper was used as the novel substrate of paper chip due to low pristine fluorescence and better performance when combining CdSe QDs. In the process of molecular imprinting, the interaction between several functional monomers and dimethoate molecule was investigated and simulated theoretically by software to improve the selectivity of the sensor. Consequently, the fabricated novel detection platform could effectively respond to dimethoate in 10 min with the concentration range of 0.45–80 μmol/L and detection limit of 0.13 μmol/L. The recovery in the spiked experiment soybean sample was in an acceptable range (97.6–104.1%) and the accuracy was verified by gas chromatography-mass spectrometry, which signified the feasibility and potential in food sampling.

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“…33 Furthermore, it has been shown that chitosan-derived MIP may be used to distinguish between the chiral forms of ketoprofen 34 and to detect and distribute S-sulpiride. 35 Norepinephrine (NEP) is a common catecholamine with a number of physiological effects, including increased blood pressure, vasoconstriction, and amplification of nerve impulse transmission. 36,37 Endogenous NEP levels in the blood may have a direct correlation with a number of illnesses.…”

Section: Introductionmentioning

confidence: 99%

Chiral acidic molecularly imprinted polymer for enantio‐separation of norepinephrine racemate

Abomuti

2024

Chirality

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We are looking into how well a copolymeric material made of poly (maleic acid–co‐4‐vinylpyridine) cross‐linked with divinylbenzene can separate L‐norepinephrine (L‐NEP) from (±)‐NEP. The initial step in this direction was the synthesis and subsequent analysis of L‐NEP‐maleimide chiral derivative. A 4‐vinylpyridine/divinylbenzene combination was copolymerized with the resultant chiral maleimide. After heating the polymer materials in a high‐alkaline environment to breakdown the connecting imide bonds, they were acidified in an HCl solution to eliminate the incorporated L‐NEP species. Fourier transform infrared spectroscopy (FTIR) and a scanning electron microscope were used to examine the imprinted L‐NEP‐imprinted materials. The manufactured L‐NEP‐imprinted materials exhibited selectivity characteristics that were over 11 times greater for L‐NEP than D‐norepinephrine. The highest capacity observed in Langmuir adsorption studies was 170 mg/g at a pH of 7. After optical separation using a column technique, it was determined that the enantiomeric excess levels of D‐norepinephrine and L‐NEP in the first feeding and subsequent recovery solutions were 95% and 81%, respectively.

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Preparation and characterization of a chiral molecularly imprinted polymer with a novel functional monomer for controlled release of S-sulpiride

Cited by 18 publications

References 26 publications

A novel smart stealth sorafenib delivery system based on the magnetic imprinting material modified by polyethylene glycol

A novel smart stealth sorafenib delivery system based on the magnetic imprinting material modified by polyethylene glycol

Rapid Detection of Dimethoate in Soybean Samples by Microfluidic Paper Chips Based on Oil-Soluble CdSe Quantum Dots

Chiral acidic molecularly imprinted polymer for enantio‐separation of norepinephrine racemate

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