Preparation and characterization of 4-isopropylcalix[4]arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography

Chelvi, S.K. Thamarai; Zhao, Jia; Chen, Lijuan; Yan, Shi Qiang; Yin, Xiaoxing; Sun, Jiaquan; Yong, Eu Leong; Wei, Qi; Gong, Yiwei

doi:10.1016/j.chroma.2013.11.025

Cited by 17 publications

(5 citation statements)

References 23 publications

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“…9 Analytical techniques reported within the literature for the determination of pindolol include spectrofluorimetry, 10 liquid chromatography-tandem mass spectrometry 11 and high-performance liquid chromatography. [12][13][14] Notably however, only one report for the electrochemical determination of pindolol exists within the literature; 15 which is a potentially rapid, facile and low cost protocol for the monitoring of such a key analyte.…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Cumba

Smith

Brownson

et al. 2015

Analyst

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Recent work has reported the first electroanalytical detection of pindolol using reduced graphene oxide (RGO) modified glassy carbon electrodes [S. Smarzewska and W. Ciesielski, Anal. Methods, 2014, 6, 5038] where it was reported that the use of RGO provided significant improvements in the electroanalytical signal in comparison to a bare (unmodified) glassy carbon electrode. We demonstrate, for the first time, that the electroanalytical quantification of pindolol is actually possible using bare (unmodified) screen-printed graphite electrodes (SPEs). This paper addresses the electroanalytical determination of pindolol utilising RGO modified SPEs. Surprisingly, it is found that bare (unmodified) SPEs provide superior electrochemical signatures over that of RGO modified SPEs. Consequently the electroanalytical sensing of pindolol is explored at bare unmodified SPEs where a linear range between 0.1 μM-10.0 μM is found to be possible whilst offering a limit of detection (3σ) corresponding to 0.097 μM. This provides a convenient yet analytically sensitive method for sensing pindolol. The optimised electroanalytical protocol using the unmodified SPEs, which requires no pre-treatment (electrode polishing) or electrode modification step (such as with the use of RGO), was then further applied to the determination of pindolol in urine samples. This work demonstrates that the use of RGO modified SPEs have no significant benefits when compared to the bare (unmodified) alternative and that the RGO free electrode surface can provide electro-analytically useful performances.

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Section: Introductionmentioning

confidence: 99%

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Cumba

Smith

Brownson

et al. 2015

Analyst

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“…Berkecz et al [60] reviewed role of CSPs based on crown ethers in LC enantioseparation. Thamarai Chelvi et al [61] in 2014, reported synthesis of 4-isopropylcalix [4] arene-capped "(3-(2-O-β-cyclodextrin)-2-hydroxypropoxy) Fig. 3.…”

Section: Protein Based Csps (Ovomucoid or α1-acid Glycoprotein (Agp)mentioning

confidence: 99%

Chromatographic methods and approaches for bioequivalence study, drug screening and enantioseparation of indapamide

Sethi

Martens

Bhushan

2024

AChrom

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Indapamide (Indp) and certain other diuretics have been abused in sports, therefore, having sensitive methods for its detection and assay in biological fluids (whole blood, plasma, serum, and urine) is of significant importance. The racemic mixture of Indp is being used as an active pharmaceutical ingredient among other commonly prescribed diuretics. The regulatory authorities and pharmaceutical industries demand analytical methods for successful enantioseparation of such molecules. The paper presents a critical overview of the scientific issues of the application of contemporary techniques involving various chromatographic approaches (with liquid or supercritical fluid as mobile phases) and capillary electrophoresis and method development, for drug screening, assay, bioequivalence studies and enantioseparation of indapamide with their results. It also covers the historical developments that led to significant breakthroughs in research and concise evaluations of research in the area.Different types of chromatographic methods (HPLC, CEC, SFC etc) discussed herein provide an insight and a choice to select a method to (i) screen Indp for drug abuse, (ii) separate, isolate and quantify the enantiomers of Indp and (iii) investigate their pharmacokinetics as markedly different species and not as a total drug. The article evaluates the field's status with a broad base and practical oriented approach so that the underlying principles are easily understood to help chemists and non-specialists gain useful insights into the field outside their specialization and provide experts with summaries of key developments. To the best of authors' knowledge there has been no attempt to review such methods for analysis of Indp and this is the first report of its kind.

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“…They attributed the observed selectivity to the cooperative functioning of calix [4]arenes and β-CDs [13]. In another study, Gong showed that the incorporation of a 4-isopropyl substituent into the structure of the calix [4]arene greatly improves the chromatographic separation of the resulting calix [4]arene/ β-cyclodextrin hybrid stationary phase [14]. Four novel carbamate and urea-linked cinchona-calixarene hybrid chiral stationary phases were prepared and evaluated for the enantioseparation of amino acids.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of a deoxycholic‐calix[4]arene hybrid‐type receptor as a chiral stationary phase for HPLC

Yaghoubnejad

Heydar

Ahmadi

et al. 2018

J of Separation Science

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We report the synthesis and enantioseparation characteristics of two novel covalently immobilized deoxycholic acid derivatives as chiral stationary phases for high-performance liquid chromatography. In the structure of the first stationary phase, the 3-position of deoxycholic acid is substituted with a 3,5-dinitrophenylcarbamoyl group and the second one has an additional calix[4]arene attached to the carboxylic group of the deoxycholic acid. The chromatographic performance of the stationary phases was evaluated with enantioseparation of N-(3,5-dinitrobenzoyl)-dl-leucine, N-(3,5-dinitrobenzoyl)-dl-valine, omeprazole, diclofop-methyl, dl-mandelic acid and (RS)-pregabalin. Comparison of the performance characteristics of the prepared chiral stationary phases provided evidence for the active involvement of the calix[4]arene unit in the chiral recognition process. Both stationary phases are chemically bonded to the silica and can be used in both normal-phase and reversed-phase modes.

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Preparation and characterization of 4-isopropylcalix[4]arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography

Cited by 17 publications

References 23 publications

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Chromatographic methods and approaches for bioequivalence study, drug screening and enantioseparation of indapamide

Preparation and evaluation of a deoxycholic‐calix[4]arene hybrid‐type receptor as a chiral stationary phase for HPLC

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