Preparation and Characterisation of Phenytoin-Loaded Alginate and Alginate-Chitosan Microparticles

Cekić, Nebojša; Savić, Snežana; Milić, Jela; Savić, Miroslav M.; Jovic, Zarko; Malesevic, Marija

doi:10.1080/10717540701604769

Cited by 14 publications

(3 citation statements)

References 25 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may be due to the linkage between the COO − group of alginate and Ca 2+ resulting in alginate bead shrinkage and giving a rigid and tight structure that prevents bead swelling. The results of this study are in agreement with Cekié et al , who reported a non‐reliable effect of chitosan on microparticle size. It was found that the protective effect against extreme environmental factors enhanced with increasing bead diameter; however, oversized beads caused inappropriate mouthfeel .…”

Section: Resultssupporting

confidence: 93%

The effect of alginate and chitosan concentrations on some properties of chitosan-coated alginate beads and survivability of encapsulated Lactobacillus rhamnosus in simulated gastrointestinal conditions and during heat processing

Abbaszadeh

Gandomi

Misaghi

et al. 2014

J. Sci. Food Agric.

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 93%

The effect of alginate and chitosan concentrations on some properties of chitosan-coated alginate beads and survivability of encapsulated Lactobacillus rhamnosus in simulated gastrointestinal conditions and during heat processing

Abbaszadeh

Gandomi

Misaghi

et al. 2014

J. Sci. Food Agric.

View full text Add to dashboard Cite

show abstract

“…Kumar et al (2006) 10 J. Singh et al Drug Deliv, suitable candidates as drug-delivery carriers (Li et al, 2009;Banyal et al, 2013). Generally, the polymeric nanoparticles can be made structurally more stable by selecting different kinds of polymers, different surfactants and organic solvents (Cekié et al, 2007;Ohashi et al, 2009;Kaur et al, 2014f). They can be easily synthesized with various desirable properties like drug release, particle size/shape and zeta potential (Verma et al, 2008;.…”

Section: Rifampicinmentioning

confidence: 98%

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

et al. 2015

View full text Add to dashboard Cite

From the early sixteenth and seventeenth centuries to the present day of life, tuberculosis (TB) still is a global health threat with some new emergence of resistance. This type of emergence poses a vital challenge to control TB cases across the world. Mortality and morbidity rates are high due to this new face of TB. The newer nanotechnology-based drug-delivery approaches involving micro-metric and nano-metric carriers are much needed at this stage. These delivery systems would provide more advantages over conventional systems of treatment by producing enhanced therapeutic efficacy, uniform distribution of drug molecule to the target site, sustained and controlled release of drug molecules and lesser side effects. The main aim to develop these novel drug-delivery systems is to improve the patient compliance and reduce therapy time. This article reviews and elaborates the new concepts and drug-delivery approaches for the treatment of TB involving solid-lipid particulate drug-delivery systems (solid-lipid micro- and nanoparticles, nanostructured lipid carriers), vesicular drug-delivery systems (liposomes, niosomes and liposphere), emulsion-based drug-delivery systems (micro and nanoemulsion) and some other novel drug-delivery systems for the effective treatment of tuberculosis and role of immunomodulators as an adjuvant therapy for management of MDR-TB and XDR-TB.

show abstract

“…P-gp is highly expressed in brain capillary endothelial cells and functions as a protective efflux transporter, ejecting molecules back out into the blood plasma, restricting their passage into the brain parenchyma [4,5]. These complex properties make phenytoin a very interesting model drug for pharmaceutical studies, as evidenced by a large number of studies available in the literature, covering a range of fields including formulation science [6,7], pharmacokinetic characterization [8,9], and pharmacodynamic investigations in seizure models [10,11]. Given the complexity of phenytoin pharmacokinetics, simultaneous investigation of the concentrations of its major metabolite 4-HPPH, although not always studied, may yield important supplementary information on its distribution and metabolism in the body, especially with respect to the in vivo evaluation of novel targeted drug delivery systems, a field which is rapidly advancing in pharmaceutical science.…”

Section: Introductionmentioning

confidence: 99%

A sensitive LC‐MS/MS method for quantification of phenytoin and its major metabolite with application to in vivo investigations of intravenous and intranasal phenytoin delivery

Prentice

Mohammad

Rizwan

2022

J of Separation Science

View full text Add to dashboard Cite

Phenytoin is a powerful antiseizure drug with complex pharmacokinetic properties, making it an interesting model drug to use in preclinical in vivo investigations, especially with regards to formulations aiming to improve drug delivery to the brain. Moreover, it has a major metabolite, 5‐(4‐hydroxyphenyl)‐5‐phenylhydantoin, which can be simultaneously studied to achieve a better assessment of its behaviour in the body. Here, we describe the development and validation of a sensitive LCMS/MS method for quantification of phenytoin and 5‐(4‐hydroxyphenyl)‐5‐phenylhydantoin in rat plasma and brain which can be used in such preclinical studies. Calibration curves produced covered a range of 7.81 to 250 ng/mL (plasma) and 23.4 to 750 ng/g (brain tissue) for both analytes. The method was validated for specificity, sensitivity, accuracy, and precision and found to be within the acceptable limits of ±15% over this range in both tissue types. The method when applied in two in vivo investigations: validation of a seizure model and to study the behaviour of a solution of intranasally administered phenytoin as a foundation for future studies into direct nose‐to‐brain delivery of phenytoin using specifically developed particulate systems, was highly sensitive for detecting phenytoin and 5‐(4‐hydroxyphenyl)‐5‐phenylhydantoin in rat plasma and brain.

show abstract

Preparation and Characterisation of Phenytoin-Loaded Alginate and Alginate-Chitosan Microparticles

Cited by 14 publications

References 25 publications

The effect of alginate and chitosan concentrations on some properties of chitosan-coated alginate beads and survivability of encapsulated Lactobacillus rhamnosus in simulated gastrointestinal conditions and during heat processing

The effect of alginate and chitosan concentrations on some properties of chitosan-coated alginate beads and survivability of encapsulated Lactobacillus rhamnosus in simulated gastrointestinal conditions and during heat processing

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

A sensitive LC‐MS/MS method for quantification of phenytoin and its major metabolite with application to in vivo investigations of intravenous and intranasal phenytoin delivery

Contact Info

Product

Resources

About