Preparation and Characterisation of Liposomes of Bergenia Ciliata Extract and Evaluation of their Hepatoprotective Activity

Latief, Uzma; Kaur, Manjot; Dar, Sajad Hussain; Thakur, Shubham; Per, Tasir S.; Tung, Gurleen Kaur; Jain, Subheet Kumar

doi:10.1016/j.xphs.2022.07.013

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…[29] El-Samaligy et al [30] formulated liposomes containing silymarin to increase oral bioavailability with mucoadhesive purpose, ensuring encapsulation efficiency and stability after 3 months of storage. The study by Latief and collaborators [31] also corroborates the hepatoprotective effect of liposomes, since the systems were developed based on the methanolic extract of Bergenia Ciliata, showing high bioavailability of bergenin against markers of liver damage, as well as high encapsulation efficiency, controlled release, and exponential improvement in changes caused by acute liver injury.…”

Section: Liposomesmentioning

confidence: 70%

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Silva

Ferreira

Soares

2023

Chemistry & Biodiversity

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Because of the increasing demand for natural products, the development of nanoformulations containing natural active ingredients requires in‐depth knowledge of the substances used, methods of obtaining, and stability profiles to ensure product quality, efficacy, and safety. Considering this, the bibliography of the last five years presented in databases (PubMed and Science Direct) was discussed in this work, discussing the study with medicinal plants to obtain active metabolites with therapeutic properties, as well as the different nano‐systems responsible for carrying these molecules. Due to the wealth of biodiversity found in the world, many species are submitted to the extraction process for several purposes. However, identifying, classifying, and quantifying the constituents of herbal matrices are crucial steps to verify their therapeutic potential. In addition, knowing the techniques of production and elaboration of nanotechnology products allows the optimization of the incorporation of herbal extracts as an innovation target. For studies to be successful, it is necessary to exhaust experimental results that guarantee the efficacy, safety, and quality of natural nanosystems, with the objective of obtaining reliable answers in nanotechnology therapy.

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Section: Liposomesmentioning

confidence: 70%

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Silva

Ferreira

Soares

2023

Chemistry & Biodiversity

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“…It regulates a variety of physiological functions such as metabolism, bile secretion, and vitamin storage. In addition, this organ detoxifies various toxic substances and is involved in the synthesis of useful compounds ( Latief et al, 2023 ). It is important in the maintenance of body functions in addition to the regulation of homeostasis, as this organ regulates various metabolic processes such as growth, disease resistance, nutrition delivery, energy flow, and reproduction.…”

Section: Introductionmentioning

confidence: 99%

Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection—biochemical and histopathological insights

Siddiqa,

Qureshi,

Raja

et al. 2024

Front. Pharmacol.

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Background: Liver disease is a serious health concern in today’s world, posing a challenge to both healthcare providers and pharmaceutical companies. Most synthetic drugs and chemicals cause liver damage accounting for approximately 10% of acute hepatitis and 50% of acute liver failure.Purpose: The present study aimed to evaluate the hepato-protective activity of an extract of chicory formulation assisted by silver nanoparticles against carbon tetra chloride (CCl4)-induced hepatic damage in rat’s liver.Methods: Rats of the Wistar strain (Rattus norvegicus) were used to test the in vivo hepato-protective efficacy at various doses. Rats were randomly divided into nine groups, each containing six rats. The groups were as follows: first group (control), second group (CCl4), third group, silymarin (20 mg/kg of body weight), fourth group (CCl4+chicory) (1.75 mg/kg of b. wt), fifth group (CCl4 + chicory at the dose of 2.35 mg/kg), sixth group (CCl4 + chicory of 3.25 mg/kg), seventh group (CCl4 +AgNPs 1.75 mg/kg of b. wt.), eighth group (CCl4 + AgNPs 2.35 mg/kg of body weight), and ninth group (CCl4 + AgNPs 3.25 mg/kg of b. wt.). Blood samples were taken 24 h after the last administration (i.e., 30th day). The blood samples were analyzed for different serum enzymes such as ALP (alkaline phosphatase), ALT (alanine transaminase), bilirubin (Blr), triglyceride, and cholesterol. Histology liver sections were performed.Results: Treatment with AgNPs and chicory extract showed significant hepato-protective activity in a dose-dependent manner. In three doses, the chicory extract at a rate of 3.25 mg/kg of body weight significantly reduced elevated levels of biochemical markers in comparison to CCl4-intoxicated rats. Histology of the liver sections from CCl4-treated rats revealed inflammation of hepatocytes, necrosis, cytoplasmic degeneration, vacuolization, and a deformed central vein. The chicory formulation extract exhibited a remarkable recovery percentage in the liver architecture that was higher than the drug (i.e., silymarin). While treatment with AgNPs also repaired the degenerative changes and restored the normal form of the liver, chicory formulation extract possessed more hepato-protective potential as compared to AgNPs by regulating biochemical and histo-pathological parameters.Conclusion: This study can be used as confirmation of the hepato-protective potential of chicory compounds for possible use in the development programs of drugs to treat liver diseases.

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“…Nowadays, BER is mainly used in the clinical treatment of chronic bronchitis [ 11 ]. BER has been shown to improve acute liver injury and liver fibrosis [ 12 , 13 ]. It has been reported that BER inhibited nuclear factor kappa B (NF-κB), and thus down-regulated tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), myeloperoxidase (MPO) and cyclooxygenase-2 (COX-2) to attenuate hepatocyte death [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing

Li,

Yang,

Cao

et al. 2023

Molecules

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Bergenin (BER), a natural component of polyphenols, has a variety of pharmacological activities, especially in improving drug metabolism, reducing cholestasis, anti-oxidative stress and inhibiting inflammatory responses. The aim of this study was to investigate the effects of BER on liver injury induced by isonicotinic acid hydrazide (INH) and rifampicin (RIF) in mice. The mice model of liver injury was established with INH (100 mg/kg)+RIF (100 mg/kg), and then different doses of BER were used to intervene. The pathological morphology and biochemical indicators of mice were detected. Meanwhile, RNA sequencing was performed to screen the differentially expressed genes and signaling pathways. Finally, critical differentially expressed genes were verified by qRT-PCR and Western blot. RNA sequencing results showed that 707 genes were significantly changed in the INH+RIF group compared with the Control group, and 496 genes were significantly changed after the BER intervention. These differentially expressed genes were mainly enriched in the drug metabolism, bile acid metabolism, Nrf2 pathway and TLR4 pathway. The validation results of qRT-PCR and Western blot were consistent with the RNA sequencing. Therefore, BER alleviated INH+RIF-induced liver injury in mice. The mechanism of BER improving INH+RIF-induced liver injury was related to regulating drug metabolism enzymes, bile acid metabolism, Nrf2 pathway and TLR4 pathway.

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Preparation and Characterisation of Liposomes of Bergenia Ciliata Extract and Evaluation of their Hepatoprotective Activity

Cited by 4 publications

References 28 publications

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection—biochemical and histopathological insights

The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing

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