Preparation and application of UPLC silica microsphere stationary phase:A review

Zhang, Tingyu; Yu, Yaru; Han, Shuiquan; Cong, Hailin; Kang, Chuankui; Shen, Youqing; Yu, Bing

doi:10.1016/j.cis.2023.103070

Cited by 1 publication

(1 citation statement)

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“…Porous materials can be divided into macroporous materials (pore size of >50 nm), mesoporous materials (pore size of 2–50 nm), and microporous materials (pore size of <2 nm) based on their pore size [ 1 ]. Silica mesoporous microspheres, which can be prepared by spray drying, polymerization–induced colloid aggregation (PICA), emulsion, template, sol–gel, and other methods [ 2 , 3 ], have physical stability, controllable particle size, no obvious cytotoxicity, good biocompatible performance, huge specific surface area and pore volume, excellent loading performance, uniform pore size, ordered arrangement, and controllable size and silanol groups [ 4 ]. Thanks to their unique properties, silica mesoporous microspheres exhibit promising applications in various fields, such as catalysis and drug delivery [ 5 , 6 , 7 , 8 ], liquid chromatography [ 9 , 10 , 11 , 12 ], heavy metal adsorption [ 13 , 14 , 15 ], functional coatings [ 16 , 17 ], and so on.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Monodisperse Silica Mesoporous Microspheres with Narrow Pore Size Distribution

Shan,

Liu,

Zhu

et al. 2024

Polymers

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The purpose of this study is to prepare monodisperse silica mesoporous microspheres with narrow pore size distribution to promote their application in the field of liquid chromatography. An improved emulsion method was used to prepare silica mesoporous microspheres, and the rotary evaporation temperature, emulsification speed, dosage of porogen DMF, and dosage of the catalyst NH3·H2O were optimized. Subsequently, these microspheres were respectively treated by alkali–heating, calcination, and sieving. The D50 (particle size at the cumulative particle size distribution percentage of 50%) of as–prepared silica mesoporous microspheres is 26.3 μm, and the D90/D10 (the ratio of particle size at a cumulative particle size distribution percentage of 90% to a cumulative particle size distribution percentage of 10%) is 1.94. The resultant silica mesoporous microspheres have distinctive pore structures, with a pore volume of more than 1.0 cm3/g, an average pore size of 11.35 nm, and a median pore size of 13.4 nm. The silica mesoporous microspheres with a large particle size, uniform particle size distribution, large average pore size and pore volume, and narrow mesopore size distribution can basically meet the requirements of preparative liquid chromatographic columns.

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