Preparation and Application of Highly Concentrated Perfluoroctylbromide Fluorocarbon Emulsions

Long, David; Long, David M.; Riess, Jean G.; Follana, R.; Burgan, Anthony R.; Mattrey, Robert F.

doi:10.3109/10731198809132595

Cited by 25 publications

(7 citation statements)

References 5 publications

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“…Newer perfluorocarbon emulsions were developed by industry that carried more oxygen than did previous products 39 ; however, regardless of oxygen capacity, a fundamental difference exists between perfluorocarbon-and hemoglobinbased red blood cell substitutes: oxygen is transported by perfluorocarbons as dissolved gas, whereas hemoglobin carries oxygen chemically bound to the protein itself. Because of the nature of the binding of oxygen by hemoglobin, oxygen is not released until hemoglobin reaches regions of the circulation where pO 2 is low (i.e., ischemic tissue).…”

Section: Perfluorocarbon-based Productsmentioning

confidence: 99%

Blood Substitutes: Basic Principles and Practical Aspects

Winslow¹

2007

Blood Banking and Transfusion Medicine

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Section: Perfluorocarbon-based Productsmentioning

confidence: 99%

Blood Substitutes: Basic Principles and Practical Aspects

Winslow¹

2007

Blood Banking and Transfusion Medicine

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“…This situation has now been entirely changed with the recent develop ment of new emulsions which are up to five times more concentrated [15,18]. Such emulsions can now be envi sioned for use in room air.…”

Section: The Fluorocarbon Approach: An Outline Of Basic Principles Amentioning

confidence: 99%

“…PFOB was initially selected for use in diagnosis owing to its radiopacity [20,58]. How ever, its emulsions also turned out to have outstanding qualities as injectable 02 carriers due to its exceptionally short organ retention time and improved emulsion stabil ity [15], Purity and definition of the carrier are obvious pre requisites for biomedical acceptability. When realized, they represent a distinct advantage of the fluorocarbon ap proach over that based on modified hemoglobins.…”

Section: The Fiuosol-da Eramentioning

confidence: 99%

“…It has an exceptionally fast excretion rate and forms stable emulsions with lecithins [15,59], owing to the lipophilic character (confirmed by a very low critical solution temperature in hexane, <-20°C [37]) induced by the presence of the bromine atom in a exposed terminal position. These unique characteristics, plus the fact that PFOB can be synthesized in a high state of purity on a large scale and that it ranks among the fluorocarbons with the highest oxygen-dissolv ing capacities, make it particularly eligible as an oxygen carrier [3], As a contrast agent, PFOB displays the unique feature of being a multidetection, injectable one.…”

Section: Which Fluorocarbons?mentioning

confidence: 99%

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Fluorocarbon-Based in vivo Oxygen Transport and Delivery Systems

Riess¹

1991

Vox Sanguinis

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The approval of Fluosol, a fluorocarbon emulsion for oxygenating the myocardium during the transluminal coronary angioplasty procedure, is a landmark in the field of injectable oxygen carriers, the so-called blood substitutes. This review discusses the advances made since this first emulsion was initially developed about 12 years ago. Attention is focused on the progress achieved in the preparation and selection of new, better-defined and faster-excreted fluorocarbons, and better surfactants, improved emulsions, knowledge of structure/property relationships along with an improved understanding of the physiologic response to their administration. These advances have led to the development of a second generation of highly concentrated, fluid and stable injectable oxygen carriers suitable for a broad range of clinical applications. Prospects for further progress and future generations of emulsions are also outlined.

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“…Aqueous emulsions of these compounds have thus been considered as potential blood substitutes for the transport of 0 2 / CO 2 • Non-transfusional indications include the treat ment of cardiac or cerebral ischemia, for cardioplegja, angioplasty and in the radio-or chemotherapy of cancer where oxygen has been shown to have a synergistic action. Such blood substitutes would also be of value for perfusion of isolated organs and in cell culture, e te [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

New formulation of blood substitutes: optimization of novel fluorinated microemulsions

Cecutti¹,

Rico²,

Lattes³

et al. 1989

European Journal of Medicinal Chemistry

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The synthesis of a nove! microemulsion system composed of a mixed fluorinated and hydrogenated oil C 8 F 17-CH 2 CH=CH-C 4 H 9 with a biocompatible hydrogenated surfactant, Montanox 80 is described. Investigation of the solubility of oxygen in these microemulsions showed that they absorbed more oxygen than Fluosol-DA which is currently used as an oxygen transporter in biomedical applications. Oxygen absorption was similar to that of blood. Light scattering studies showed that the system was composed of small sized aggregates which should in principle be compatible with blood. The toxicity of the rnicroemulsions was tested after intraperitoneal injection in rats, and in mice after intravenous administration. The microemulsions appeared to be well tolerated. These results show promise for the development of oxygen transporting compounds. Résumé-Nouvelle stratégie dans la formulaôon de substituts du sang: opômisation de nouvelles microémulsions fluorées. Pour la première fois, nous décrivons des sytèmes de microémulsions d'une huile mixte fluorée et hydrogénée C 8 F 17 CH 2-CH=CH-C 4 H 9 à l'aide d'un tensioactif hydrogéné biocompatible: le Montanox 80. Les études de solubilité de l' oxyg ène dans ces microémulsions montrent qu'elles absorbent davantage l'oxygène que l'émulsion Fluosol DA, actuellement utilisée dans le domaine biomédical des transporteurs d'oxygène. Cette absorption s'effectue dans des propor tions analogues à celles du sang. Du point de vue de la toxicité de ces systèmes, des mesures de la diffusion de la lumière mettent en évidence des agrégats de petite taille compatibles théoriquement avec le système sanguin. La toxicité des,microé mulsions a été testée en i.p. chez le rat et en i.v. chez la souris. Les microémulsions semblent bien tolérées. Le travail décrit ici constitue donc une ouverture d'une nouvelle voie de recherche dans le domaine des transporteurs d'oxygène. fluorinated. microemulsioos/ oxygen transporting compounds

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Preparation and Application of Highly Concentrated Perfluoroctylbromide Fluorocarbon Emulsions

Cited by 25 publications

References 5 publications

Blood Substitutes: Basic Principles and Practical Aspects

Blood Substitutes: Basic Principles and Practical Aspects

Fluorocarbon-Based in vivo Oxygen Transport and Delivery Systems

New formulation of blood substitutes: optimization of novel fluorinated microemulsions

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