Preparation and antioxidant activities of important traditional plant polysaccharides

Liu, Yang; Sun, Yun‐Zhang; Huang, Gangliang

doi:10.1016/j.ijbiomac.2018.01.086

Cited by 195 publications

(68 citation statements)

References 42 publications

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“…Plant polysaccharides have biocompatibility, biodegradability, nontoxicity, and some specific therapeutic activities [10,11]. The biological activity of a polysaccharide primarily depends on its molecular weight, and type and content of acidic groups [12].…”

Section: Introductionmentioning

confidence: 99%

Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights

Chen

Sun

Ouyang

2020

Oxidative Medicine and Cellular Longevity

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Corn silk polysaccharide (CSP0; molecular weight=124 kDa) was degraded by ultrasonication to obtain five degraded polysaccharides, namely, CSP1, CSP2, CSP3, CSP4, and CSP5, with molecular weights of 26.1, 12.2, 6.0, 3.5, and 2.0 kDa, respectively. The structures of these polysaccharides were characterized by FT-IR, 1H NMR, and 13C NMR analyses. The antioxidant activities, including scavenging ability for hydroxyl radicals and DPPH free radicals, chelation ability for Fe2+ ions, and reducing ability of CSP increased with decreased molecular weight of CSPs within 6.0 to 124 kDa. However, antioxidant activity weakened when the molecular weight of CSPs reached 3.5 and 2 kDa. CSP3 with a molecular weight of 6.0 kDa exhibited the strongest antioxidant activity. After protection with 60 μg/mL CSPs, the viability of human renal proximal tubular epithelial cells (HK-2) damaged by nano-COM crystals increased, the level of reactive oxygen species decreased, and the amount of COM crystal adhered onto the cell surface decreased. The ability of CSPs to protect cells from CaOx crystal damage was consistent with their antioxidant activity. CSPs can specifically combine with CaOx crystal to inhibit the conversion of calcium oxalate dihydrate crystal to calcium oxalate monohydrate crystal. All these results showed that the activity of CSPs was closely correlated with molecular weight. A very high or low molecular weight of CSPs was not conducive to their activity. CSPs, especially CSP3 with a molecular weight of 6.0 kDa, can be used as a potential antistone drug.

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Section: Introductionmentioning

confidence: 99%

Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights

Chen

Sun

Ouyang

2020

Oxidative Medicine and Cellular Longevity

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“…Because of the fact that most of the modern therapies to treat lifestyle diseases involve serious side effects, there is a growing interest in the use of natural therapeutics for prevention and treatment of many human diseases caused by oxidative stress that include immune disorders and cancer. In this context, Australian sweet lupin seeds possess huge potential as they are nutritionally rich and contain non-starch polysaccharides that display a range of important biological activities [9,[25][26][27][28][29] with least side effects.…”

Section: Cell Viabilitymentioning

confidence: 99%

Biological activities and characterization of polysaccharides from the three Australian Sweet Lupins

Thambiraj

Reddy

Phillips

et al. 2019

International Journal of Food Properties

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Lupin is a major rotational crop produced abundantly in Australia. Three varieties of sweet lupins are grown in Australia depending on soil types and climatic conditions; these are white lupin (Lupinus albus), blue lupin (Lupinus angustifolius), and yellow lupin (Lupinus luteus). In this study, polysaccharides from the three lupin species have been extracted with hot water and a range of their biological activities investigated. The antioxidant activities of lupin polysaccharides have been measured in terms of ABTS •+ radical and hydroxyl radical scavenging activities, and their affinity to chelate with iron. Immuneenhancing power of the lupin polysaccharides was examined by measuring their capacity to stimulate the macrophages (RAW 264.7) to release TNF-α and nitric oxide. The prebiotic activities were determined against the beneficial probiotics such as Lactobacillus rhamnosus DR20, Lactobacillus acidophilus LAFTI L10, Bifidobacterium lactis DR10, and Bifidobacterium animalis BB-12. Polysaccharides from the three lupin species have exhibited significant antioxidant, immunostimulatory, and prebiotic activities. The results demonstrated that blue lupins displayed the best activities, and therefore are expected to possess high potential to be used as nutraceutical and functional ingredients with significant therapeutic value. FT-IR spectroscopic technique was employed for a preliminary structural characterization. Studies involving surface morphology and thermal behavior have indicated that the lupin polysaccharides are suitable for end product development.

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“…Plant avonols exhibit anticancer, proapoptotic, antioxidant, antibacterial, and anti brotic effects [31,32,33,34,35]. Additionally, polysaccharides exert several health-promoting effects, such as antibacterial, antitumor, antioxidant, and anti-in ammatory effects [36,37,38,39,40,41,42]. Despite exerting these positive effects, green tea avonols and polysaccharides, unlike catechins, have received little attention with respect to their use and functionality.…”

Section: Introductionmentioning

confidence: 99%

Combination of green tea catechins, polysaccharides, and flavonols against urban fine dust particle-induced bronchial damage mediated by modulation of inflammation factors and airway cilia

Kim

Choi

et al. 2020

Preprint

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Background Many studies have reported that environmental pollution has become a serious public health issue. Airborne fine dust particles (FDPs) have been identified as major toxins in air pollution that threaten human respiratory health. Developing strategies for defense against FDPs is one of the primary goals of air pollution research. Results While searching for an anti-FDP reagent, we found that green tea extract (GTE) and green tea fractions rich in flavonol glycosides (FLGs) and crude green tea polysaccharides (CTPs) had protective effects against FDP-stimulated cellular damage in the BEAS-2B airway epithelial cell line. The results demonstrated that GTE, FLGs, and CTPs significantly increased viability and lowered oxidative stress levels in FDP-treated cells. Major catechin and flavonol compounds increased cell survival, and (-)-epigallocatechin gallate (EGCG) and myricetin exerted synergistic effects on cell survival under FDP stimulation. Combined treatment with GTE, FLGs, and CTPs also exerted synergistic protective effects on cells, and the green tea components attenuated FDP-induced elevations in inflammatory gene expression. Moreover, the green tea components increased the proportion of ciliated cells and upregulated ciliogenesis in the airway in FDP-stimulated BEAS-2B cells. Conclusions Our findings provide insights into how natural phytochemicals protect the airway and suggest that green tea could be used to reduce FDP-induced airway damage as an individual therapeutic agent or as an ingredient in pharmaceutical and cosmeceutical products.

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Preparation and antioxidant activities of important traditional plant polysaccharides

Cited by 195 publications

References 42 publications

Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights

Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights

Biological activities and characterization of polysaccharides from the three Australian Sweet Lupins

Combination of green tea catechins, polysaccharides, and flavonols against urban fine dust particle-induced bronchial damage mediated by modulation of inflammation factors and airway cilia

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