Preparation and Antimicrobial Activity of s‐Triazine Hydrazones of 7‐Hydroxy Coumarin and their Metal Complexes

Jani, G. R.; Vyas, K. B.; Franco, Zudas

doi:10.1155/2009/649654

Cited by 10 publications

(4 citation statements)

References 4 publications

(3 reference statements)

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“…They have been used as an intermediate for the preparation of heterocycles displaying useful activities [ 8 , 9 ]. Recently Jani et al has reported the synthesis and antimicrobial activities of complexes prepared using ligands containing triazine and hydrazone functionalities [ 10 ]. The vast range of pharmacological applications of these classes of compounds encouraged us to synthesize compounds containing both triazine and hydrazone moieties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Crystal Structures and Spectroscopic Properties of Triazine-Based Hydrazone Derivatives; A Comparative Experimental-Theoretical Study

et al. 2015

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We report here a comparative theoretical and experimental study of four triazine-based hydrazone derivatives. The hydrazones are synthesized by a three step process from commercially available benzil and thiosemicarbazide. The structures of all compounds were determined by using the UV-Vis., FT-IR, NMR (1H and 13C) spectroscopic techniques and finally confirmed unequivocally by single crystal X-ray diffraction analysis. Experimental geometric parameters and spectroscopic properties of the triazine based hydrazones are compared with those obtained from density functional theory (DFT) studies. The model developed here comprises of geometry optimization at B3LYP/6-31G (d, p) level of DFT. Optimized geometric parameters of all four compounds showed excellent correlations with the results obtained from X-ray diffraction studies. The vibrational spectra show nice correlations with the experimental IR spectra. Moreover, the simulated absorption spectra also agree well with experimental results (within 10–20 nm). The molecular electrostatic potential (MEP) mapped over the entire stabilized geometries of the compounds indicated their chemical reactivates. Furthermore, frontier molecular orbital (electronic properties) and first hyperpolarizability (nonlinear optical response) were also computed at the B3LYP/6-31G (d, p) level of theory.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Crystal Structures and Spectroscopic Properties of Triazine-Based Hydrazone Derivatives; A Comparative Experimental-Theoretical Study

et al. 2015

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“…Delivering the current of 150 mA subjected to electroshock to the animals through the corneal electrodes for a period of 0.2 seconds. The animal was observed convulsive responses for 30 min [33]. Minimal Neurotoxicity.…”

Section: Primary Evaluationmentioning

confidence: 99%

Design and synthesis of anti-convulsant and anti-bacterial activity of new hydrazone derivatives

2020

Biointerface Res Appl Chem

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Synthesis of new hydrazone derivatives, starting from 2-(3, 4-Dichloro-benzoyl)-benzoic acid to 2-(3, 4-dichloro-benzoyl) - benzoic acid ethyl ester than converted into 2- (3, 4-Dichloro-benzoyl)-benzoic acid hydrazide with a substituted aldehyde. The structure of newly synthesized compounds was confirmed by analytical and spectral analysis IR, 1HNMR and MASS. For docking study, we took structures of ligand compounds (i.e. AK-series Compounds) and target protein structures into ‘pdb’ file format. Three compounds as possible anti-convulsant AK-1, AK-2 &Ak-4 were considered for compounds Ak-1 was not found suitable for anti-convulsant activity; while AK-2 & AK-4 have the capacity to show anti-convulsant activity with lesser affinity than controls. As an overall conclusion, except Ak-1, other compounds can be further used for anti- convulsant activity. Anti-convulsant activities were performed on rats by using maximal Electroshock Seizure test and minimal Neurotoxicity. Compound 2- (3, 4 – Dichloro-benzoyl)-benzoic acid (4- chloro-benzylidene) (AK-2) shows good anti-convulsant activity. The in-vitro antibacterial strains Escherichia coli MTCC 1573), and staphylococcus aureus (MTCC 1430), were used. Compound 2-(3, 4-Dichloro-benzoyl)-benzoic acid (2-notro-benzylidene-hydrazide (AK-1) gives the highest activity against Escherichia coli (MTCC 1573) and Staphylococcus aureus (MTCC-1430).

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“…Besides, they found in different oils as ''lavender oil, cinnamon bark, oil and cassia oil'' [4]. Moreover, coumarin derivatives have changed uses such as '' optical brightening agents, laser dyes, cosmetic industry agrochemical industries and food additives'' [5][6][7]. Furthermore, Coumarin derivatives have important biological activity as antibacterial, antifungal, anti-oxidant, anti-allergic, antiinflammatory, anti-thrombotic, hepatoprotective, anti-viral, anticarcinogenic activities [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Biological Approach of N’-(3-(Hydroxy Imino) Butan-2-ylidene)-2-Oxo-2H-Chromene-3-Carbohydrazide Complexes

Rr¹,

Km²,

Ee³

2017

Mod Chem appl

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A series of metal complexes of Cu(П), Co(П), Ni (П), Cd(П) and Hg(П) complexes with N'-(3-(hydroxyimino) butan-2-ylidene)-2-oxo-2H-chromene-3-carbohydrazide (H 2 L) were prepared. The structures illuminated by elemental and thermal analysis, besides spectroscopic methods (IR, 1 H NMR, and UV-visible, MS) and physical measurements (molar conductance and magnetic susceptibility). In addition, DFT method used to approve the geometry of solid complexes. From conductmetric measurements, all complexes were non-electrolytic and formed by molar ratio 1:2 expect Hg(П) complexes by 1:1. Moreover, the biological activity (Antibacterial, antifungal and DNA binding) performed for all prepared compounds.

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Preparation and Antimicrobial Activity of s‐Triazine Hydrazones of 7‐Hydroxy Coumarin and their Metal Complexes

Cited by 10 publications

References 4 publications

Synthesis, Crystal Structures and Spectroscopic Properties of Triazine-Based Hydrazone Derivatives; A Comparative Experimental-Theoretical Study

Synthesis, Crystal Structures and Spectroscopic Properties of Triazine-Based Hydrazone Derivatives; A Comparative Experimental-Theoretical Study

Design and synthesis of anti-convulsant and anti-bacterial activity of new hydrazone derivatives

Synthesis, Characterization and Biological Approach of N’-(3-(Hydroxy Imino) Butan-2-ylidene)-2-Oxo-2H-Chromene-3-Carbohydrazide Complexes

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