Preparation and anticoagulant properties of heparin-like electrospun membranes from carboxymethyl chitosan and bacterial cellulose sulfate

Song, Weikang; Zeng, Qinhuan; Yin, Xijie; Zhu, Li; Gong, Tao; Pan, Changjiang

doi:10.1016/j.ijbiomac.2018.09.133

Cited by 28 publications

(14 citation statements)

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“…[22] et al can effectively remove heavy metal ions in water. In addition, a large number of studies have shown that the chitosan composite membrane has good anti-adhesion [23], coagulation [24,25] and antibacterial [26,27] effects. However, a membrane consisting of chitosan alone has disadvantages such as low mechanical strength, high brittleness, poor heat resistance and poor water resistance, which limit the applications of chitosan [19,28,29,30].…”

Section: Introductionmentioning

confidence: 99%

Mechanical and Water-Resistant Properties of Eco-Friendly Chitosan Membrane Reinforced with Cellulose Nanocrystals

et al. 2019

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Environmentally benign and biodegradable chitosan (CS) membranes have disadvantages such as low mechanical strength, high brittleness, poor heat resistance and poor water resistance, which limit their applications. In this paper, home-made cellulose nanocrystals (CNC) were added to CS to prepare CNC/CS composite membranes through mechanical mixing and solution casting approaches. The effects of CNC dispersion patterns and CNC contents on the properties of composite membranes were studied. The analysis of the surface and cross-section morphology of the membranes showed that the dispersion performance of the composite membrane was better in the case that CNC was dissolved in an acetic acid solution and then mixed with chitosan by a homogenizer (Method 2). CNC had a great length-diameter ratio and CNC intensely interacted with CS. The mechanical properties of the composite membrane prepared with Method 2 were better. With a CNC content of 3%, the tensile strength of the composite membrane reached 43.0 MPa, 13.2% higher than that of the CNC-free membrane. The elongation at break was 41.6%, 56.4% higher than that of the CNC-free membrane. Thermogravimetric, contact angle and swelling analysis results showed that the addition of CNC could improve the heat and water resistance of the chitosan membrane.

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Section: Introductionmentioning

confidence: 99%

Mechanical and Water-Resistant Properties of Eco-Friendly Chitosan Membrane Reinforced with Cellulose Nanocrystals

et al. 2019

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“…The incorporation of the sulfate groups in the structure of chitosan improves its compatibility with blood by its complexing ability with the blood components (Heise et al, 2018). The anticoagulant activity of the chitosan and its derivatives is also greatly influenced by many factors such as degree of sulfonation (Xiong et al, 2011, Shagdarova et al, 2016, Subhapradha et al, 2013, Yang et al, 2013, Drozd et al, 2019, Song et al, 2018, Ouerghemmi et al, 2018, Drozd et al, 2017, Skorik et al, 2017, Ragab et al, 2018). Further, the N-alkylation of chitosan to primary or secondary chitosan derivatives and finally to quaternary chitosan derivatives increase the water solubility of the chitosan derivatives (Mustafa et al, 2015, Szymańska and Winnicka, 2015, Yadu et al, 2017, Cheung et al, 2015, Avadi et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…This indicated that all the synthesized derivatives had a faster onset of action and potency than nicoumalone. This may be because of the expected higher water solubility of the synthesized derivative because of the presence of sulphate group and the quaternary ammonium group (Heise et al, 2018, Shagdarova et al, 2016, Drozd et al, 2019, Song et al, 2018). However, after 3 h of drug administration the potency of compounds was less than nicoumalone.…”

Section: Discussionmentioning

confidence: 99%

“…The chitosan has a similar close structure like heparin (Heise et al, 2018). Based on this feature, many chitosan derivatives as anticoagulants have been synthesized (Vongchan et al, 2002, Vonghan et al, 2003, Vikhoreva et al, 2005, Huang et al, 2003, Xiong et al, 2011, Baumann and Faust, 2001, Shagdarova et al, 2016, Subhapradha et al, 2013, Yang et al, 2013, Drozd et al, 2019, Song et al, 2018, Ouerghemmi et al, 2018, Drozd et al, 2017, Skorik et al, 2017, Park et al, 2004, Ragab et al, 2018). Recently (Heise et al, 2018), it has been stated that incorporation of the sulfate groups in the structure of chitosan improve its compatibility with blood and increase its anticoagulation effects by its complexing ability with the blood.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, characterization and anticoagulant activity of chitosan derivatives

Imran

Sajwan

Alsuwayt

et al. 2020

Saudi Pharmaceutical Journal

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Chitosan derivatives are reported as anticoagulants in the literature. This work was undertaken to develop novel chitosan derivatives as anticoagulants. The sulfonated derivatives of chitosan were formed by the reaction of chitosan derivatives with chlorosulfonic acid in N,N-dimethylformamide. The structures of these derivatives were established by FTIR and 1H NMR spectra. The prepared derivatives were evaluated for their in vivo anticoagulant effects by the tail bleeding method in Wistar rats utilizing nicoumalone as a standard drug. The results revealed that the sulfonation of the chitosan increases its anticoagulant activity. The developed compounds exhibited faster onset of action and potency than nicoumalone after one hour of the drug administration. The sulphated N-alkyl derivatives of chitosan were more potent anticoagulants than sulfated quaternary derivatives/sulfated chitosan. It is also suggested to develop analogs of Ethyl chitosan sulfate (4b) and Benzyl chitosan sulfate (4c), which may provide some more fruitful anticoagulants having faster onset of action as well as longer duration of action and possessing a balanced hydrophilic/lipophilic character.

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“…Due to the unique properties of BNC, such as high water-holding capability, excellent mechanical properties in a wet state, nontoxicity, and biocompatibility, it has been widely employed in the production of biomedical materials. − More interestingly, BNC provides high moisture permeability and high exudate absorption, which are important aspects of functional wound dressings . Impregnation of different chemical compounds such as glycerin, chitosan, and vaccarin and numerous chemical modifications of BNC such as oxidation, carboxymethylation, sulfation, amino grafting, etc., are the focus of innovative strategies aiming to meet different requirements of various biomaterials. Aminoalkylsilane grafting, which is also known as a silylation, is an easy, simple, and efficient amino grafting reaction.…”

Section: Introductionmentioning

confidence: 99%

Functionalization of Aminoalkylsilane-Grafted Bacterial Nanocellulose with ZnO-NPs-Doped Pullulan Electrospun Nanofibers for Multifunctional Wound Dressing

Shahriari-Khalaji

Lin

et al. 2021

ACS Biomater. Sci. Eng.

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High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings. The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application. Pullulan (Pul) is a nontoxic polymer that can promote wound healing. Zinc oxide nanoparticles (ZnO-NPs) are well-known as a safe antibacterial agent. In this study, aminoalkylsilane was chemically grafted on a BNC membrane (A-g-BNC) and used as a bridge to combine BNC with Pul-ZnO-NPs hybrid electrospun nanofibers. FTIR results confirmed the successful production of A-g-BNC/Pul-ZnO. The obtained dressing demonstrated blood clotting performance better than that of BNC. The dressing showed an ability to release ZnO, and its antibacterial activity was up to 5 log values higher than that of BNC. The cytotoxicity of the dressing toward L929 fibroblast cells clearly showed safety due to the proliferation of fibroblast cells. The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO. The new functional dressing, fabricated with a cost-effective and easy method, not only showed excellent antibacterial activity but could also accelerate wound healing.

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Preparation and anticoagulant properties of heparin-like electrospun membranes from carboxymethyl chitosan and bacterial cellulose sulfate

Cited by 28 publications

References 50 publications

Mechanical and Water-Resistant Properties of Eco-Friendly Chitosan Membrane Reinforced with Cellulose Nanocrystals

Mechanical and Water-Resistant Properties of Eco-Friendly Chitosan Membrane Reinforced with Cellulose Nanocrystals

Synthesis, characterization and anticoagulant activity of chitosan derivatives

Functionalization of Aminoalkylsilane-Grafted Bacterial Nanocellulose with ZnO-NPs-Doped Pullulan Electrospun Nanofibers for Multifunctional Wound Dressing

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