Preparation and adsorption performance research of large-volume hollow mesoporous polydopamine microcapsules

Tao, Caihong; Chen, Tiandi; Liu, Hui; Su, Sisi

doi:10.1557/mrc.2019.51

Cited by 13 publications

(6 citation statements)

References 26 publications

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“…PDA, according to Nieto et al plays a primary role in and treatment of cancer, being per se an antineoplastic system, meaning it selectively kills cancer cells, especially in the case of breast cancer, without causing toxic effects to healthy cells [ 148 ]. A novel type of hollow PDA (HMPDA) was reported by Tao et al who demonstrated that morphology control of PDA and their surface properties are fundamental for nanomedicine applications [ 149 ]. Drug adsorption capability is in fact strictly correlated to PDA surface area and their strategy produced PDA with enhanced surface area, granting an improved drug loading.…”

Section: Mnp Based Therapy and Theranosticsmentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical properties. Thanks to these features, melanin plays an important multifunctional role in the design of new platforms for nanomedicine where this material works not only as a mechanical support or scaffold, but as an active component for imaging, even multimodal, and simple or synergistic therapy. The number of examples of bio-applications of MNP increased dramatically in the last decade. Here, we review the most recent ones, focusing on the multiplicity of functions that melanin performs in theranostics platforms with increasing complexity. For the sake of clarity, we start analyzing briefly the main properties of melanin and its derivative as well as main natural sources and synthetic methods, moving to imaging application from mono-modal (fluorescence, photoacoustic, and magnetic resonance) to multi-modal, and then to mono-therapy (drug delivery, anti-oxidant, photothermal, and photodynamic), and finally to theranostics and synergistic therapies, including gene- and immuno- in combination to photothermal and photodynamic. Nanomedicine aims not only at the treatment of diseases, but also to their prevention, and melanin in nature performs a protective action, in the form of nanopigment, against UV-Vis radiations and oxidants. With these functions being at the border between nanomedicine and cosmetics nanotechnology, recently examples of applications of artificial MNP in cosmetics are increasing, paving the road to the birth of the new science of nanocosmetics. In the last part of this review, we summarize and discuss these important recent results that establish evidence of the interconnection between nanomedicine and cosmetics nanotechnology.

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Section: Mnp Based Therapy and Theranosticsmentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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“…The PDA was coated onto CuMSN@DOX NPs by following the previous publications [48,55]. Initially, 50 mg of CuMSN@DOX NPs were added into 1 mg/mL solution of dopamine hydrochloride in Tris buffer (10 mM, pH 8.5) and continuously stirred under dark conditions at room temperature for 10 h. PDA-coated black-colored solid was collected by centrifugation and washed thrice with distilled water to remove un-polymerized dopamine molecules from the surface.…”

Section: Pda Coating Onto Cumsn@doxmentioning

confidence: 99%

Polydopamine-Coated Copper-Substituted Mesoporous Silica Nanoparticles for Dual Cancer Therapy

2022

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Combinational therapy using chemodynamictherapy (CDT) and photothermal therapy (PTT) is known to enhance the therapeutic outcome for cancer treatment. In this study, a biocompatible nano formulation was developed by coating polydopamine (PDA) over doxorubicin (DOX)-loaded copper-substituted mesoporous silica (CuMSN) nanoparticles. PDA coating not only allowed selective photothermal properties with an extended DOX release but also enhanced the water solubility and biocompatibility of the nanocomposites. The nanocomposites displayed a monodispersed shape and pH-dependent release characteristics, with an outstanding photothermal conversion and excellent tumor cell inhibition. The cellular-uptake experiments of CuMSN@DOX@PDA in A549 cells indicated that nanoparticles (NPs) aided in the enhanced DOX uptake in tumor cells compared to free DOX with synergistic anti-cancer effects. Moreover, the cell-viability studies displayed remarkable tumor inhibition in combinational therapy over monotherapy. Thus, the synthesized CuMSN@DOX@PDA NPs can serve as a promising platform for dual cancer therapy.

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“…Furthermore, in vitro synthesis of melanin offers the possibility to manipulate the size and surface characteristics of the particles. Consequently, both the loading efficiency and the release of the drug can be controlled, as the drug adsorption capability of synthetic melanin is dependent on its surface area [ 30 ]. Melanin, once injected, makes a local depot for several weeks, allowing local release.…”

Section: Potential Applications Of Melanin In Medicinementioning

confidence: 99%

Applications of Melanin and Melanin-Like Nanoparticles in Cancer Therapy: A Review of Recent Advances

Cuzzubbo

Carpentier

2021

Cancers

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Thanks to the growing knowledge about cancers and their interactions with the immune system, a huge number of therapeutic cancer vaccines have been developed in the past two decades. Despite encouraging results in pre-clinical models, cancer vaccines have not yet achieved significant clinical efficacy. Several factors may contribute to such poor results, including the difficulty of triggering a strong immune response and the immunosuppressive tumor microenvironment. Many strategies are currently being explored. Different types of adjuvants have been incorporated into vaccine formulations to improve their efficacy, as cancer antigens are usually poorly immunogenic. Nanoparticle systems are promising tools as they act as carriers for antigens and can be surface-modified so that they specifically target antigen-presenting cells in lymph nodes. Bioinspired nanomaterials are ideal candidates thanks to their biocompatibility. Recently, melanin-based nanoparticles were reported to efficiently localize into draining lymphoid tissues and trigger immune responses against loaded antigens. In addition, by virtue of their photochemical properties, melanin-based nanoparticles can also play an immunomodulatory role to promote anti-cancer responses in the context of photothermal therapy. In this review, we discuss the above-mentioned properties of melanin, and summarize the promising results of the melanin-based cancer vaccines recently reported in preclinical models.

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Preparation and adsorption performance research of large-volume hollow mesoporous polydopamine microcapsules

Abstract: Abstract

Cited by 13 publications

References 26 publications

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Polydopamine-Coated Copper-Substituted Mesoporous Silica Nanoparticles for Dual Cancer Therapy

Applications of Melanin and Melanin-Like Nanoparticles in Cancer Therapy: A Review of Recent Advances

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