Preparation and adsorption performance of molecularly imprinted polymers for Kaempferol

Zhang, Zhimiao; Ye, Yun; Li, Chunli

doi:10.1080/19443994.2013.781731

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…In addition, the slope of plot a1 (−1.35) was lower than that of plot a2 (−0.42), which indicated that the amounts of high affinity sites were higher in MIP-4VP, while the Scatchard plot for MIP-AM was only a single straight line. The linear regression equation was Q / C = −0.42 Q + 19.54 ( R 2 = 0.94, b1), suggesting that homogeneous recognition sites for quercetin were formed in MIP-AM. , K d and Q max were calculated to be 5.14 μg/mL and 78.84 μg/g, respectively (MIP-AM, Table S1 b1).…”

Section: Resultsmentioning

confidence: 99%

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A SPE Method with Two MIPs in Two Steps for Improving the Selectivity of MIPs

et al. 2019

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Molecular imprinted polymers (MIPs) have been widely applied in the separation of compounds in complex matrixes due to the high selectivity for molecular recognition. However, MIPs not only adsorb the targeted molecule but also adsorb structurally similar analogues, which leads to some loss of selectivity. In this work, for improvement of selectivity of MIPs, a novel solid-phase extraction method with two MIPs in two steps (TMIPs-TSPE) was established. As a demonstration, two MIPs were prepared by using quercetin as the template and 4-vinylypyridine (4VP) and acrylamide (AM) as representative functional monomers, respectively. The adsorption properties and kinetic characteristics of the two MIPs showed that they had a distinct adsorption capacity and adsorption mechanism, which is the basis for establishment of TMIPs-TSPE. The TMIPs-TSPE method first used one of the two MIPs as adsorbent to extract molecules from a solution mixture containing quercetin and three analogues. Then the other MIP was used to achieve a second extraction of the extracted molecules from the first step. The results showed that the unique targeted molecule quercetin was extracted, which illustrates that TMIPs-TSPE improved the specificity of the MIPs. The process of molecular recognition can be influenced by the intensity of binding sites between MIPs and molecules. Moreover, it may also depend on the spatial orientation of molecules entering the cavities of MIPs, which deserves more attention as one important property for the development of molecular imprinting. These results demonstrated that the novel TMIPs-TSPE method contributes to the improved selectivity of MIPs.

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Section: Resultsmentioning

confidence: 99%

“…The linear regression equation was Q/C = −0.42Q + 19.54 (R 2 = 0.94, b1), suggesting that homogeneous recognition sites for quercetin were formed in MIP-AM. 28,38 K d and Q max were calculated to be 5.14 μg/mL and 78.84 μg/g, respectively (MIP-AM, Table S1 b1).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

A SPE Method with Two MIPs in Two Steps for Improving the Selectivity of MIPs

et al. 2019

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“…The Scatchard equation is an equation used to describe the interaction between adsorbed materials and imprinted molecules in the adsorption process. The analysis of adsorption isotherm data with this equation is helpful in obtaining information about the affinity of adsorption sites and the maximum adsorption capacity [ 22 , 23 ]. The specific data are shown in Table 2 and Figure S2 .…”

Section: Resultsmentioning

confidence: 99%

Study on the Selectivity of Molecular Imprinting Materials Determined through Hydrogen Bonding on Template Molecular Structures of Flavonoids

Guan,

Wang,

et al. 2024

Molecules

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Molecular imprinting technology is widely used for the specific identification of compounds, but the selective recognition mechanisms of the same compounds still need to be further studied. Based on differences in hydrogen bond size and orientation, molecularly imprinted polymers (MIPs) were designed to adsorb flavonols with the same parent core and different hydroxyl groups. A surface-imprinted material was designed with silicon dioxide as the carrier, myricetin as the template molecule, and methacrylic acid (MAA) as the functional monomer. Scanning electron microscopy (SEM), Brunauer–Emmett–Teller surface area (BET) analyses, Fourier-transform infrared spectroscopy (FT-IR), and other characterization experiments were carried out. The intrinsic mechanism of the MIPs was also explored. The MIPs showed good adsorption of myricetin and other flavonoids through hydrogen bonding and steric hindrance. The adsorption capacity was 3.12–9.04 mg/g, and the imprinting factor was 1.78–3.37. Flavonoids with different hydroxyl groups in different numbers and directions had different hydrogen bond strengths with functional monomers. R2, R4, and R1 on 2-phenylchromogenone had stronger electronegativity, and the hydroxyl group was also more likely to form and have stronger hydrogen bonds. The hydroxyl negativity and the degree of steric hindrance of flavonoids played a major role in the recognition of molecularly imprinted materials. This study is of great significance for the synthesis of and selection of templates for analogous molecular imprinting materials.

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Preparation of Isorhamnetin Molecularly Imprinted Polymer Microspheres by Modified Precipitation Polymerization

Dong

Zhai

2021

Proceedings of the International Petroleum and Petrochemical Technology Conference 2020

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Preparation and adsorption performance of molecularly imprinted polymers for Kaempferol

Cited by 5 publications

References 13 publications

A SPE Method with Two MIPs in Two Steps for Improving the Selectivity of MIPs

A SPE Method with Two MIPs in Two Steps for Improving the Selectivity of MIPs

Study on the Selectivity of Molecular Imprinting Materials Determined through Hydrogen Bonding on Template Molecular Structures of Flavonoids

Preparation of Isorhamnetin Molecularly Imprinted Polymer Microspheres by Modified Precipitation Polymerization

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