Preovulatory Secretion of Progesterone, Luteinizing Hormone, and Prolactin in 4-Day and 5-Day Cycling Rats

Hashimoto, Itaru; Isomoto, Nahoko; Eto, Mutsuko; Kawaminami, Mitsumori; Sunazuka, Chiaki; Ueki, N.

doi:10.1095/biolreprod36.3.599

Cited by 26 publications

(10 citation statements)

References 29 publications

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“…Taya et al [32] have reported that an injection of exogenous progesterone postponed the time of the preovulatory LH surge and ovulation by 24 hr. It has been also shown that the concentrations of plasma PRL from 15:00 hr through 23:00 hr on the day of proestrus remained consistently higher in 5-day cycling rats than in 4-day cycling rats [10] and progesterone secretion remained significantly higher during the day of diestrus in 5-day cycling rats than in 4-day cycling rats. Injection of a sufficient amount of antiprogesterone serum at 23:00 hr on the day of metestrus in 5-day cycling rats advanced ovulation and completion of the cycle by 1 day in the majority of animals [12].…”

Section: Discussionmentioning

confidence: 92%

“…The lack of thyroid hormone has been known to produce reproductive abnormalities, including irregular menstrual or estrous cycle, amenorrhea and sterility in many species of female mammals [1,9,10,19,24,31]. Thyroidectomy has been reported to cause decreased basal plasma levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), and a smaller LH surge on the day of proestrus [2,4,29].…”

Section: Effects Of Stress On Hypothalamo-hypophysial-adrenalmentioning

confidence: 99%

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Influence of Thiouracil-induced Hypothyroidism on Adrenal and Gonadal Functions in Adult Female Rats.

Tohei

Imai

Watanabe

et al. 1998

The Journal of Veterinary Medical Science

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ABSTRACT. The effect of hypothyroidism on adrenals and gonads in adult female rats was investigated throughout the estrous cycle. Hypothyroidism was induced by administration of 4-Methyl-2-Thiouracil (Thiouracil) in the drinking water. The weight of ovaries and adrenals, and the plasma levels of corticosterone decreased in hypothyroid rats as compared with euthyroid rats throughout the estrous cycle. Hypothyroidism resulted in decreased concentrations of plasma LH on the day of diestrus and proestrus, whereas the plasma concentrations of prolactin and progesterone increased as compared with euthyroid rats. The weight of uteri and plasma concentrations of estradiol decreased during the day of diestrus and proestrus in hypothyroid rats as compared with euthyroid rats. To further clarify the dysfunction of hypothalamo-hypophysial-adrenal axis in hypothyroid rats, animals were stressed by immobilization for 3 hr. In hypothyroid rats, a marked increase in plasma levels of ACTH in response to immobilization stress was observed compared to euthyroid control, whereas increases in plasma concentrations of corticosterone were much smaller in hypothyroid than euthyroid rats. These results clearly indicate that hypothyroidism causes both gonadal and adrenal disturbances in adult female rats. The increased concentrations of plasma progesterone may be due to hypersecretion of prolactin during the day of proestrus and estrus, which in turn result in disruption of the estrous cycle. -KEY WORDS: adrenal, gonad, hyperprolactinemia, hypothyroidism.J. Vet. Med. Sci. 60(4): 439-446, 1998 hypothyroidism on these two axes throughout the estrous cycle in adult female rats. MATERIALS AND METHODS Animals and treatments:Adult female Wistar-Imamichi rats (The Imamichi Institute for Animal Reproduction, Ibaraki, Japan) were used throughout the present study. Animals were maintained on a 14 hr light and 10 hr dark lighting schedule (light on at 05:00 hr). The room was kept at 23-26°C. They received a standard laboratory diet and water ad libitum. Hypothyroidism was induced by administration of 0.03% 4-Methyl-2-Thiouracil (Thiouracil: Wako Pure Chemical Industries, Ltd. Osaka, Japan) in the drinking water. We have confirmed the effectiveness of Thiouracil in our previous study [35]. Each rat of all experimental group was confirmed vaginal smear every day during administration of Thiouracil (until 32 days after administration of Thiouracil for first group (20 rats) and 16 days after treatment for second group (160 rats). At the 4th estrous cycle (16 days after the initiation of Thiouracil treatment), 5 animals of each group (total 160 adult female rats) were sacrificed by decapitation every 6 hr throughout 4-day estrous cycle. Trunk blood was collected and centrifuged immediately and plasma was separated and stored at 20°C until assayed tri-iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), LH, FSH, prolactin (PRL), estradiol, progesterone, adrenocorticotropic hormone (ACTH) and corticosterone. After the decapitation, ov...

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Section: Discussionmentioning

confidence: 92%

Section: Effects Of Stress On Hypothalamo-hypophysial-adrenalmentioning

confidence: 99%

Influence of Thiouracil-induced Hypothyroidism on Adrenal and Gonadal Functions in Adult Female Rats.

Tohei

Imai

Watanabe

et al. 1998

The Journal of Veterinary Medical Science

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“…The marked decrease of LH and FSH could explain the ovulation and oestrous cycle blockade by the plant extracts and clomid. Several authors demonstrated that the LH release surges at the proestrous stage are responsible for ovulation (Brown-Grant et al, 1970;Gallo, 1981;Hashimoto et al, 1987). All substances able to inhibit this release could provoke an ovulation disruption by decreasing the number of mature follicles or inducing an oestrous cycle disruption at a rest stage.…”

Section: Discussionmentioning

confidence: 99%

Effects of some traditional plant extracts on rat oestrous cycle compared with Clomid

Benie

Duval

Thieulant

2003

Phytotherapy Research

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It is well known that the plant kingdom contains numerous bioactive substances affecting the regulation of reproduction. The present study was undertaken to examine the putative contraceptive effects of three traditional plant extracts from Côte d'Ivoire Pharmacopea. It concerns Afrormosia laxiflora (Papilionacea), Pterocarpus erinaceus (Papilionacea) and Cola nitida (Sterculiacea) stem bark. Data showed that treatment of rats with these plant extracts induced ovulation and oestrous cycle blockade at the dioestrous II stage. The analysis of the principal hormones involved in oestrous cycle regulation showed that the plant extracts decreased gonadotropin release (both LH and FSH). In fact, A. laxiflora, P. erinaceus and C. nitida extracts inhibited gonadotropin release as an antiestrogen-like substance.

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“…A lower threshold for induction of the ovulatory surge of LH could negate the relatively slow rate of follicular growth expected in an H-2h animal. Likewise, an increased secretion of L H during the surge could reduce the lifespan and function of the subsequent CL (as in rats with 4-day cycles ;Hashimoto et al, 1987). Since B6 mice show both 4-and 5-day cycles, non-H-2-mediated influences on the neuroendocrine axis may affect, but cannot consistently overcome, the infuence of H-2' alleles at the ovary.…”

Section: Discussionmentioning

confidence: 99%

Polygenic Influences on the Length of Oestrous Cycles in Inbred Mice Involve MHC Alleles*

Lerner

Anderson

Harrison

et al. 1992

Int J Immunogenetics

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Genetic influences on female reproductive cycles were analysed in histocompatibility-congenic strains of mice. Oestrous cycles of young, virgin mice of inbred-congenic strains, hybrid crosses (F1), and parental-hybrid backcrosses (F2) were monitored for 3 months. Oestrous cycles were categorized by length (inter-oestrous interval): 4, 5, 6, or 7-14 days. Mice with the following H-2 haplotypes had a greater proportion of 5-day oestrous cycles: H-2b, H-2r, H-2h2, H-2h4, and H-2i5. In contrast, the H-2k and H-2d haplotypes had mostly 4-day oestrous cycles. Influences of H-2 haplotype were seen on two genetic backgrounds, C57BL/10Sn and C3H. Non-H-2 alleles were also implied by different patterns of cycles between strains with the same H-2b haplotype: C57BL/10Sn with predominantly 5-day cycles vs. C57BL/6J with a mix of 4- and 5-day cycles. The genetic basis for strain differences was investigation in F1 hybrids and their backcrosses. F1 hybrids of an H-2b (C57BL/10Sn; 5-day cycles) and an H-2k (B10.BR; 4-day cycles) strain had mostly 5-day cycles, indicating dominance of an H-2b allele(s). However, F1 hybrids from the reciprocal B6 x B10 cross (both H-2b) also display a preponderance of 5-day cycles, indicating dominance of a non-H-2 autosomal allele from the C57BL/10Sn strain. Among F2 mice, a '4-day' phenotype segregated with homozygosity for the k haplotype (P < 0.05, chi 2). These findings demonstrate the influence of genetic differences at the major histocompatibility complex on oestrous cycles.

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Preovulatory Secretion of Progesterone, Luteinizing Hormone, and Prolactin in 4-Day and 5-Day Cycling Rats

Cited by 26 publications

References 29 publications

Influence of Thiouracil-induced Hypothyroidism on Adrenal and Gonadal Functions in Adult Female Rats.

Influence of Thiouracil-induced Hypothyroidism on Adrenal and Gonadal Functions in Adult Female Rats.

Effects of some traditional plant extracts on rat oestrous cycle compared with Clomid

Polygenic Influences on the Length of Oestrous Cycles in Inbred Mice Involve MHC Alleles*

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