Preoperative versus pathological staging of rectal cancer—challenging the indication of neoadjuvant chemoradiotherapy

Fritz, Stefan; Killguss, Hansjörg; Schaudt, André; Lazarou, Lazaros; Sommer, Christof M.; Richter, G. M.; Küper-Steffen, Regina; Feilhauer, Katharina; Köninger, Jörg

doi:10.1007/s00384-020-03751-3

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…An increase in neoadjuvant therapy during the pandemic was reported in a meta-analysis [14] and a registry-based study in England [5] . However, unlike the United States [20] , European countries [21] , [22] , [23] , and China [24] , neoadjuvant therapy is not the standard first choice treatment for locally advanced rectal cancer in Japan. Contrary to our expectations, the number of neoadjuvant chemoradiotherapies for rectal cancer significantly and temporarily increased during an early stage of the pandemic.…”

Section: Discussionmentioning

confidence: 99%

“…The prefectural governments requested residents and institutions to take action to prevent infection without enforcing action or penalties on violators. In terms of colorectal cancer treatment, the standard treatment for patients with locally advanced rectal cancer differs between Japan and other countries; resection is recommended as the first treatment choice in Japan, while neoadjuvant therapy is recommended in the United States [20] , European countries [21] , [22] , [23] , and China [24] . Several studies have reported the impact of the COVID-19 pandemic on colorectal cancer diagnosis and treatment in Japan.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Changes in colorectal cancer treatment during the COVID-19 pandemic in Japan: Interrupted time-series analysis using the National Database of Japan

Fujita

Yamaguchi²,

Nagashima

et al. 2023

Cancer Epidemiology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in colorectal cancer treatment during the COVID-19 pandemic in Japan: Interrupted time-series analysis using the National Database of Japan

Fujita

Yamaguchi²,

Nagashima

et al. 2023

Cancer Epidemiology

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“…A recent study that explored the staging performance of MRI in rectal cancer, using surgical pathology as a standard of reference, showed that MRI LN status was correctly assigned in 68% of cases, overstaged in 28%, and understaged in 4%. Moreover, only 40% of MRI-positive LN cases were pathologically confirmed[ 54 ]. These results are in line with a FDG-PET/MRI study where N status was overstaged by MRI in 22.6% of patients and by PET/MRI in 8% of cases; correct N status was assigned by MRI in 58% of patients and by PET/MRI in 79% of patients[ 55 ].…”

Section: Clinical Stage Of Nodal Metastasesmentioning

confidence: 99%

Role of one-step nucleic acid amplification in colorectal cancer lymph node metastases detection

Crafa¹,

Vanella²,

Catalano³

et al. 2022

WJG

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Current histopathological staging procedures in colorectal cancer (CRC) depend on midline division of the lymph nodes (LNs) with one section of hematoxylin and eosin staining. Cancer cells outside this transection line may be missed, which could lead to understaging of Union for International Cancer Control Stage II high-risk patients. The one-step nucleic acid amplification (OSNA) assay has emerged as a rapid molecular diagnostic tool for LN metastases detection. It is a molecular technique that can analyze the entire LN tissue using a reverse-transcriptase loop-mediated isothermal amplification reaction to detect tumor-specific cytokeratin 19 mRNA. Our findings suggest that the OSNA assay has a high diagnostic accuracy in detecting metastatic LNs in CRC and a high negative predictive value. OSNA is a standardized, observer-independent technique, which may lead to more accurate staging. It has been suggested that in stage II CRC, the upstaging can reach 25% and these patients can access postoperative adjuvant chemotherapy. Moreover, intraoperative OSNA sentinel node evaluation may allow early CRC to be treated with organ-preserving surgery, while in more advanced-stage disease, a tailored lymphadenectomy can be performed considering the presence of aberrant lymphatic drainage and skip metastases.

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Extramural vascular invasion as an independent prognostic marker in locally advanced rectal cancer: propensity score match pair analysis

et al. 2022

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Preoperative versus pathological staging of rectal cancer—challenging the indication of neoadjuvant chemoradiotherapy

Cited by 4 publications

References 12 publications

Changes in colorectal cancer treatment during the COVID-19 pandemic in Japan: Interrupted time-series analysis using the National Database of Japan

Changes in colorectal cancer treatment during the COVID-19 pandemic in Japan: Interrupted time-series analysis using the National Database of Japan

Role of one-step nucleic acid amplification in colorectal cancer lymph node metastases detection

Extramural vascular invasion as an independent prognostic marker in locally advanced rectal cancer: propensity score match pair analysis

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