Preoperative Ultrasonic Assessment of Thin Melanocytic Skin Lesions Using a 100-MHz Ultrasound Transducer: A Comparative Study

Gambichler, Thilo; Moussa, Georg; BAHRENBERG, KATHARINA; Vogt, Michael; Ermert, H.; Weyhe, Dirk; Altmeyer, Peter; Hoffmann, Klaus

doi:10.1111/j.1524-4725.2007.33175.x

Cited by 42 publications

(74 citation statements)

References 21 publications

(92 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, higher frequencies also lead to decreased depth of penetration by the ultrasound waves; thus, the choice of the probe frequency depends on the diameter and site of the lesion. 101 High-resolution B-mode ultrasound has traditionally and primarily been used to assess the depth/thickness of melanoma tumors. Reflex transmission imaging (RTI) is a form of high-resolution ultrasound that can be used in combination with white-light digital photography for classification of pigmented lesions.…”

Section: Diagnostic Ultrasoundmentioning

confidence: 99%

The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs

Rigel

Russak

Friedman

2010

CA: A Cancer Journal for Clinicians

336

274

View full text Add to dashboard Cite

Early detection of malignant melanoma remains the key factor in lowering mortality from this cancer. Recognizing the importance of this issue 25 years ago, our group at New York University published in CA: A Cancer Journal for Clinicians the mnemonic "ABCD" to facilitate the early diagnosis of melanoma. Studies have demonstrated the usefulness of this paradigm in enhancing early melanoma diagnosis as a part of clinical examinations, mass screenings, and public education programs. Approaches to melanoma diagnosis have dynamically evolved during the ensuing quarter century. In the 1990s, dermoscopy enabled the recognition of new subsurface features to differentiate between malignant and benign pigmented lesions. During the last decade, new computer-based technologies have improved diagnostic sensitivity and specificity and may result in optimizing lesion selection for biopsy and pathology review. Despite all of the advances in melanoma diagnosis, timely recognition, detection, and rapid treatment of melanoma remain critical. Although pathologic examination remains the gold standard for diagnosis, this cancer has the potential to be diagnosed through noninvasive approaches because of its cutaneous location. From the development of the ABCDs through current attempts that use complex computer algorithms and genetic markers, a clinician's ability to detect melanoma in its earliest form has been augmented. However, a "good clinical eye" is still fundamental to selecting the lesions for evaluation among the sea of those that are prevalent. As current approaches are refined and new techniques are developed, the improved ability to diagnose this cancer will hopefully enhance reaching the goal of reducing melanoma mortality. CA Cancer J Clin 2010;60:301-316.

show abstract

Section: Diagnostic Ultrasoundmentioning

confidence: 99%

The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs

Rigel

Russak

Friedman

2010

CA: A Cancer Journal for Clinicians

336

274

View full text Add to dashboard Cite

show abstract

“…In plane lesions, high frequencies (50 MHz Cortex, 100 MHz DUB) lead to a better correlation with the histologically measured size. Gambichler et al [9] were able to show an overestimation of both ultrasonic frequencies compared to histological measurement. Exophytic-growing or deeply infiltrating melanocytic lesions, however, can only be proved by using low frequencies (20 MHz to 50 MHz maximum), depending on size.…”

Section: Resultsmentioning

confidence: 94%

“…US has been used in the diagnosis of skin tumors, connective tissue diseases, vascular disorders, and subcutaneous processes [3] as well as to measure the thickness of skin [4][5][6][7][8]. A reliable differentiation between benign melanocytic nevi [9], and melanomas is not possible with clinical ultrasound [10].…”

Section: Introductionmentioning

confidence: 99%

Clinical application of multiphoton tomography in combination with high‐frequency ultrasound for evaluation of skin diseases

König

Speicher²,

Köhler

et al. 2010

Journal of Biophotonics

View full text Add to dashboard Cite

Journal of BIOPHOTONICSThe first-ever application of high-frequency ultrasound combined with multiphoton tomography (MPT) and dermoscopy in a clinical trial is reported. 47 patients with different dermatoses such as benign and malign skin cancers, connective tissue diseases, inflammatory skin diseases, and autoimmune bullous skin diseases have been investigated with (i) state-of-the-art and highly sophisticated ultrasound systems for dermatology, (ii) the femtosecond laser multiphoton tomograph and (iii) dermoscopes. Dermoscopy provides two-dimensional color images of the skin surface with a magnification up to 70Â. Depending on the ultrasonic frequencies from 7.5 MHz to 100 MHz, the signal depth varies from about 1 mm to 80 mm. Vertical ultrasound wide-field images provide fast information on depth and volume of the lesion. The 100 MHz ultrasound allows imaging with resolutions down to 16 mm (axial) and 32 mm (lateral). Multiphoton tomography provides 0.36 Â 0.36 Â 0.001 mm 3 horizontal optical sections of a particular region of interest with submicron resolution down to 200 mm tissue depth. The autofluorescence of mitochondrial coenzymes, keratin, melanin, and elastin as well as the network of collagen structures can be imaged. The combination of ultrasound and MPT opens novel synergistic possibilities in diagnostics of skin diseases with a special focus on the early detection of skin cancer as well as the evaluation of treatments.Screenshot of human skin of the forearm. For a better visualization the A-scans at different depths are encoded in a 2D B-scan where the brightness represents the amplitudes.

show abstract

“…Gambichler és mtsai 20-, ill. 100 Mhz ultrahangot alkalmaztak, utóbbit a melanocitás bôrléziók vastagságának mérésére az irodalomban elsôként. Bár a 100 Mhz ultrahanggal mért tumorvastagságok nagyobb arányban egyeztek a szövettani ér-tékkel, a szórás minimális volt, a mért korrelációs értékek (0,99) azonosak voltak mindkét felbontással mért csoportban (13).…”

Section: Táblázat 5 áBra)unclassified