“…The a priori defined primary confounder model included patient baseline characteristics, multiple socioeconomic factors including estimated household income, 25 , 27 preoperative factors, as well as pre-existing physical and psychiatric comorbidities, along with concomitant substance use disorders. We also adjusted the analysis for the year in which the procedure was performed, the type of anaesthesia (general anaesthesia or monitored anaesthesia care), duration of surgery, and the Charlson Comorbidity Index.…”