Preoperative thrombocytosis and leukocytosis among ovarian cancer patients are associated with postoperative death

Barber, E.L.; Boggess, John F.; Le, Linda Van; Kim, K.H.; Bae‐Jump, Victoria L.; Brewster, Wendy R.; Soper, John T.; Gehrig, Paola A.

doi:10.1016/j.ygyno.2015.01.101

Cited by 3 publications

(3 citation statements)

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“…Low albumin, low hematocrit, elevated creatinine, and thrombocytopenia are associated with poor performance status and have been associated with complications among a diversity of surgical patients(15-21). In regard to cancer biology, both white blood cells and platelets have been linked to aggressive cancer biology, poor prognosis, and postoperative complications among ovarian cancer patients(22-25). The predictors of major complication that we investigated included patient demographics, including age and race; preoperative laboratory values, including platelet count, white blood cell count, creatinine, albumin, and hematocrit; and patient comorbidities, including diabetes, hypertension, chronic obstructive pulmonary disease (COPD), myocardial infarction (MI) within 6 months, history of cerebrovascular accident (CVA) and history of transient ischemic attack (TIA).…”

Section: Methodsmentioning

confidence: 99%

A preoperative personalized risk assessment calculator for elderly ovarian cancer patients undergoing primary cytoreductive surgery

Barber

Rutstein

Miller

et al. 2015

Gynecologic Oncology

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Objective Cytoreductive surgery for ovarian cancer has higher rates of postoperative complication than neoadjuvant chemotherapy followed by surgery. If patients at high risk of postoperative complication were identified preoperatively, primary therapy could be tailored. Our objective was to develop a predictive model to estimate the risk of major postoperative complication after primary cytoreductive surgery among elderly ovarian cancer patients. Methods Patients who underwent primary surgery for ovarian cancer between 2005-2013 were identified from the National Surgical Quality Improvement Project. Patients were selected using primary procedure CPT codes. Major complications were defined as grade 3 or higher complications on the validated Claviden-Dindo scale. Using logistic regression, we identified demographic and clinical characteristics predictive of postoperative complication. Results We identified 2,101 ovarian cancer patients of whom 35.9% were older than 65. Among women older than 65, the rate of major postoperative complication was 16.4%. Complications were directly associated with preoperative laboratory values (serum creatinine, platelets, white blood cell count, hematocrit), ascites, white race, and smoking status, and indirectly associated with albumin. Our predictive model had an area under receiver operating characteristic curve of 0.725. In order to not deny patients necessary surgery, we chose a 50% population rate of postoperative complication which produced model sensitivity of 9.8% and specificity of 98%. Discussion Our predictive model uses easily and routinely obtained objective preoperative factors to estimate the risk of postoperative complication among elderly ovarian cancer patients. This information can be used to assess risk, manage postoperative expectations, and make decisions regarding initial treatment.

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Section: Methodsmentioning

confidence: 99%

A preoperative personalized risk assessment calculator for elderly ovarian cancer patients undergoing primary cytoreductive surgery

Barber

Rutstein

Miller

et al. 2015

Gynecologic Oncology

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“…Haemoglobin levels have been found predictive of the primary response to irradiation, of the chance of local recurrence, as well as of overall (OS) [4], and of Disease-Free Survival (DFS) [5]. Recently, an association between elevated platelet count and earlier metastasis has been observed in a variety of solid neoplasms, including colorectal [6][7][8][9][10], gastric [11,12], cervical [13], ovarian [14][15][16], pancreatic [17,18], lung [19][20][21], and breast [22] cancers. The exact pathomechanism behind the relationship between thrombocytosis and neoplasia is yet unknown to date.…”

Section: Introductionmentioning

confidence: 99%

Thrombocytosis as a Prognostic Marker of Survival in Patients with Head and Neck Tumors

Szilasi¹

2020

BJSTR

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Objectives:The correlation between cancer-related thrombocytosis and worse survival has been described with a variety of solid neoplasms. However, only limited data are available on the prognostic significance of thrombocytosis in patients with head and neck tumors.We aimed to investigate the association between the survival of patients with head and neck cancer and the elevated platelet count. Methods:We conducted an analysis of the data from 339 patients with head and neck squamous cell carcinoma of various stages and locations. Preoperative platelet counts were analysed; thrombocytosis was defined as 300 G/L or higher. The influence of platelet count on survival was calculated with the Kaplan-Meier method, as well as with multivariate Cox regression. Results:In patients with excessive thrombocytosis, survival was significantly worse even after adjusting the multivariate analysis for gender, age, as well as tumor stage, grade, and location. The magnitude of thrombocytosis differed among tumors of different anatomical location. Conclusion:Thrombocytosis may be related to a worse survival in head and neck squamous cell carcinoma patients. The impact of elevated platelet count appears to vary with the anatomical location of the tumor -this feature may be worth further investigation.include conventional haematological indices such as Complete

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“…Az utóbbi időben egyre több szolid tumornál (colorectalis [4][5][6][7], gyomor [8,9], méhnyak [10], petefészek [11][12][13], hasnyálmirigy [14,15], tüdő [16][17][18], emlő [19]) igazolják, hogy a magasabb vérlemezkeszám roszszabb túléléssel és koraibb áttétképződéssel jár.…”

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A magasabb vérlemezkeszám mint a fej-nyak tumoros betegek túléléssel kapcsolatos esetleges prognosztikai faktora

Szilasi¹,

Jósa

Zrubka

et al. 2021

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Összefoglaló. Bevezetés: Régóta ismert, hogy a daganatokhoz társuló emelkedett vérlemezkeszám rosszabb túléléssel társul. Fej-nyak tumoros betegek esetében kevés információ áll rendelkezésünkre ezzel az összefüggéssel kapcsolatban. Célkitűzés: Vizsgálatunk célja a fej-nyak daganatos betegek prognózisa és a thrombocytosis közötti összefüggés tanulmányozása volt. Módszer: Különféle stádiumú és lokalizációjú, 312, fej-nyak tumoros beteg retrospektív adatait elemeztük. A műtét előtti vérlemezkeszámokat vizsgáltuk, a 300 G/l feletti értéket tekintettük emelkedett thrombocytaszámnak. A vérlemezkeszám és a túlélés közötti kapcsolatot Kaplan–Meier-módszerrel és multivariáns Cox-regresszióval elemeztük. Eredmények: Emelkedett thrombocytaszám mellett szignifikánsan rosszabb túlélést észleltünk (5 éves túlélés: p = 0,007, betegségmentes túlélés: p = 0,192). Ez az összefüggés még akkor is fennállt, amikor multivariáns analízissel nemre, korra, stádiumra, differenciáltsági fokra, lokalizációra, valamint fehér- és vörösvérsejtszámra korrigáltuk az elemzést (5 éves túlélés: p = 0,027). A különféle anatómiai lokalizációkban eltérő mértékben észleltünk 300 G/l feletti vérlemezkeszámot (algarat: 43,6%, sub- és supraglottis: 35,8%, szájüreg: 35,7%, hangszalag: 22,5%, szájgarat: 19%, multiplex: 50%), ez azonban nem befolyásolta szignifikánsan a túlélést (p = 0,603). Következtetés: A daganathoz társuló thrombocytosis összefüggésbe hozható a fej-nyak tumoros betegek rosszabb túlélésével. Az egyes lokalizációkban talált különböző vérlemezkeszámok nem befolyásolják eltérő mértékben a túlélést. Orv Hetil. 2021; 162(17): 676–682. Summary. Introduction: The association between cancer-related thrombocytosis and worse survival has been described with a variety of solid neoplasms. However, only limited data are available on the prognostic significance of elevated platelet count in head and neck tumours. Objective: We aimed to investigate the correlation between the survival of patients with head and neck cancer and thrombocytosis. Method: We conducted an analysis of the data from 312 patients with head and neck squamous cell carcinoma of various stages and locations. Preoperative platelet counts were analysed; elevated platelet count was defined as 300 G/l or higher. The influence of platelet count on survival was calculated with the Kaplan–Meier method as well as with multivariate Cox regression. Results: In patients with excessive thrombocytosis, survival was significantly worse (overall survival: p = 0.007, disease-free survival: p = 0.192). This association remained significant even after adjusting the multivariate analysis for age, gender as well as tumour stage, grade, location, red and white blood cell count (overall survival: p = 0.027). The magnitude of thrombocytosis differed among tumours of different anatomical locations (hypopharynx: 43.6%, sub- and supraglottis: 35.8%, oral cavity: 35.7%, vocal cord: 22.5%, oropharynx: 19%, multiple: 50%), but this did not affect survival significantly (p = 0.603). Conclusion: Elevated platelet count may be related to a worse prognosis in head and neck squamous cell carcinoma patients. The impact of thrombocytosis does not vary with the anatomical location of the tumour. Orv Hetil. 2021; 162(17): 676–682.

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Preoperative thrombocytosis and leukocytosis among ovarian cancer patients are associated with postoperative death

Cited by 3 publications

References 0 publications

A preoperative personalized risk assessment calculator for elderly ovarian cancer patients undergoing primary cytoreductive surgery

A preoperative personalized risk assessment calculator for elderly ovarian cancer patients undergoing primary cytoreductive surgery

Thrombocytosis as a Prognostic Marker of Survival in Patients with Head and Neck Tumors

A magasabb vérlemezkeszám mint a fej-nyak tumoros betegek túléléssel kapcsolatos esetleges prognosztikai faktora

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