Preoperative Technetium Tc 99m Sestamibi Imaging: Paving the Way to Minimal-Access Parathyroid Surgery

Sofferman, Robert A.; Nathan, Muriel H.; Fairbank, Jonathan T.; Foster, Roger S.; Krag, David N.

doi:10.1001/archotol.1996.01890160011002

Cited by 83 publications

(52 citation statements)

References 8 publications

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“…The dual-phase planar scintigraphy protocol employed in this study yielded a sensitivity of 82 per cent, somewhat lower than the best reported sensitivity of 91 per cent in a study using the same technique 6 .…”

Section: Discussioncontrasting

confidence: 65%

“…There is also evidence that single-photon emission computed tomography and subtraction techniques may offer improved sensitivity, albeit marginal, over the simpler dual-phase technique 7 . The best reported sensitivity of 91 per cent 6 still leaves a substantial false-negative rate, which may influence the surgical approach and cure rate following surgery.…”

Section: Introductionmentioning

confidence: 99%

“…One important factor is gland size. It has been suggested that the large size of parathyroid tumours, coupled with a corresponding increase in blood flow, is responsible for sestamibi uptake in abnormal glands 6 . However, false-negative results have been reported for large glands and very small adenomas may be detectable, indicating that size is not the only important factor 8,9 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

P-glycoprotein expression is associated with sestamibi washout in primary hyperparathyroidism

Gupta

Ahmed

Happerfield

et al. 2007

British Journal of Surgery

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Section: Discussioncontrasting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

P-glycoprotein expression is associated with sestamibi washout in primary hyperparathyroidism

Gupta

Ahmed

Happerfield

et al. 2007

British Journal of Surgery

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“…Therefore, it would be useful to be able to distinguish N-type hyperplasia from D-type hyperplasia with simple clinical techniques. MIBI and Tetro scintigraphies have been proposed as preoperative methods of locating parathyroid ade- noma in primary hyperparathyroidism [11,[26][27][28]. In patients with 2HPT, however, the efficacy of these techniques has been reported to be less [11,26].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Histological Findings and Parathyroid Scintigraphy in Hemodialysis Patients with Secondary Hyperparathyroid Glands

et al. 2005

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Abstract. To determine the usefulness of parathyroid scintigraphy in histological estimation for secondary hyperparathyroidism (2HPT) using Tc-99m sestamibi or Tc-99m tetrofosmin. Tc-99m sestamibi (MIBI) and Tc-99m tetrofosmin (Tetro) parathyroid imaging following double-phase study, magnetic resonance imaging (MRI), and ultrasound were performed on 14 patients with 2HPT. All patients underwent parathyroidectomy. The uptake of two tracers in parathyroid areas was compared with the histopathologic findings. Forty-nine parathyroid glands were surgically explored and histologically proven to be hyperplastic. Of these, 42 were diagnosed with nodular type (N-type) hyperplasia, and 7 with diffuse type (D-type) hyperplasia. MIBI and Tetro parathyroid imagings detected 34 and 35 parathyroid glands, respectively. The sensitivity of MIBI was determined to be 76.2% (32/42) for N-type, and 28.6% (2/7) for D-type. The sensitivity of Tetro was determined to be 78.6% (33/42) for N-type and 28.6% (2/7) for D-type. The sensitivity of both MIBI and Tetro was significantly higher for N-type than for D-type, 76.2% (32/42) vs. 28.6% (2/7) in MIBI, P = 0.022; 78.6% (33/42) vs. 28.6% (2/7) in Tetro, P = 0.015. The sensitivity of MRI was determined to be 76.2% (32/42) for N-type and 42.9% (3/7) for D-type, and the sensitivity of ultrasound was 71.4% (30/42) for N-type and 71.4% (5/7) for D-type. There was no significant difference in the sensitivity of MRI or ultrasound between N-type and D-type. The uptake ratios of MIBI and Tetro were also greater for N-type than for D-type. The detectability of both MIBI and Tetro was greater for N-type than for D-type. Tc-99m MIBI or Tc-99m Tetro parathyroid scintigraphy therefore may be used clinically to distinguish N-type from D-type parathyroid gland hyperplasia.

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“…1 Application of intraoperative gamma probe is being increasingly used in detection of ectopic parathyroid tissue or confirmation of total excision of parathyroid tissue. [2][3][4] But the utility of gamma probe is not established in cases with intrathyroidal parathyroid adenoma. Intraoperative parathyroid hormone (IOPTH) measurement also can be used for confirmation of possible intrathyroidal parathyroid adenomas.…”

Section: Introductionmentioning

confidence: 99%

The Role of Intraoperative Gamma Probe and Parathyroid Hormone Measurement in the Localization of Intrathyroidal Parathyroid Adenoma

Soydal¹,

Genç²,

Araz³

et al. 2012

World Journal of Endocrine Surgery

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Preoperative Technetium Tc 99m Sestamibi Imaging: Paving the Way to Minimal-Access Parathyroid Surgery

Cited by 83 publications

References 8 publications

P-glycoprotein expression is associated with sestamibi washout in primary hyperparathyroidism

P-glycoprotein expression is associated with sestamibi washout in primary hyperparathyroidism

Comparison of Histological Findings and Parathyroid Scintigraphy in Hemodialysis Patients with Secondary Hyperparathyroid Glands

The Role of Intraoperative Gamma Probe and Parathyroid Hormone Measurement in the Localization of Intrathyroidal Parathyroid Adenoma

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