Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis

Russo, Elena; Guizzardi, Mathilda; Canali, Luca; Gaino, Francesca; Costantino, Andrea; Mazziotti, Gherardo; Lania, Andrea; Uccella, Silvia; Di Tommaso, Luca; Ferreli, Fabio; Malvezzi, Luca; Spriano, Giuseppe; Mercante, Giuseppe

doi:10.1007/s11154-023-09845-x

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…In recent years, there are no unique reviews and meta-analyses in the field related to this study, such as the systematic review by Detopoulou et al ( 48 ) published in March 2023, which showed that MPV was associated with cardiovascular complications in patients with thyroid tumours, and lower MPV was associated with metastasis, which lacked a breakdown of the types of thyroid tumours, and the summaries were too general, with even some ambiguities with the conclusions of the original study. Russo et al ( 49 ), published in October 2023, included 12 studies with a total of 7,599 patients with DTC and conducted a meta-analysis of the relationship between preoperative blood levels of NLR, LMR, and PLR with DFS, which revealed that no significant correlation was found between these three blood markers and DFS. Our study explored the prognostic value of a more comprehensive set of blood markers, but it cannot be denied that we lacked the statistical tools to analyse them in a more scientific manner, making it difficult to arrive at a definitive result.…”

Section: Discussionmentioning

confidence: 99%

Association between blood inflammatory indicators and prognosis of papillary thyroid carcinoma: a narrative review

Cai,

Zhao,

Zhang

et al. 2024

Gland Surg

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Background and Objective Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer, accounting for up to 85–90% of cases, with the best overall prognosis and mostly inert tumors. However, some tumors are aggressive, causing metastasis, recurrence, and other bad outcomes. Preoperative inflammation indices, such as lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and systemic immune inflammation index (SII) in peripheral blood, have recently gained attention as nonspecific markers of inflammatory response in thyroid. In this study, we reviewed the interactions between preoperative inflammatory factors and outcomes in patients with PTC. Methods This is a narrative review. We searched for English articles published between January 2014 and December 2023 on PubMed and Web of Science to identify how do these blood indicators affect the prognosis of patients with papillary thyroid cancer. Key Content and Findings All retrievable indicators that have predictive significance for the prognosis of PTC were included, and the prognosis mainly included tumor-node-metastasis (TNM) staging, survival rate, recurrence, clinical and pathological risk factors such as lymph node metastasis (LNM), etc. From the general evidence, the prognostic predictive value of cell count alone was unknown, and low LMR was usually associated with poor prognosis, high NLR and high platelet-to-lymphocyte ratio (PLR) usually indicated poor prognosis. Conclusions These minimally invasive, low-cost, and easily obtainable blood indicators provide convenience for precise prognosis management of PTC patients, but many of the findings are conflicting and need to be validated by prospective studies that are more multi-sample, multi-centre and incorporate factors such as age that affect the immune response.

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Section: Discussionmentioning

confidence: 99%

Association between blood inflammatory indicators and prognosis of papillary thyroid carcinoma: a narrative review

Cai,

Zhao,

Zhang

et al. 2024

Gland Surg

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Development of machine learning models to predict papillary carcinoma in thyroid nodules: The role of immunological, radiologic, cytologic and radiomic features

Canali,

Gaino,

Costantino

et al. 2024

Auris Nasus Larynx

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Association of neutrophil-lymphocyte ratio with all-cause and cardiovascular mortality in US adults with diabetes and prediabetes: a prospective cohort study

Chen,

Che,

Lai

et al. 2024

BMC Endocr Disord

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Background The neutrophil-lymphocyte ratio (NLR) is a novel hematological parameter to assess systemic inflammation. Prior investigations have indicated that an increased NLR may serve as a potential marker for pathological states such as cancer and atherosclerosis. However, there exists a dearth of research investigating the correlation between NLR levels and mortality in individuals with diabetes and prediabetes. Consequently, this study aims to examine the connection between NLR and all-cause as well as cardiovascular mortality in the population of the United States (US) with hyperglycemia status. Methods Data were collected from a total of 20,270 eligible individuals enrolled for analysis, spanning ten cycles of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. The subjects were categorized into three groups based on tertiles of NLR levels. The association of NLR with both all-cause and cardiovascular mortality was evaluated using Kaplan-Meier curves and Cox proportional hazards regression models. Restricted cubic splines were used to visualize the nonlinear relationship between NLR levels and all-cause and cardiovascular mortality in subjects with diabetes after accounting for all relevant factors. Results Over a median follow-up period of 8.6 years, a total of 1909 subjects with diabetes died, with 671 deaths attributed to cardiovascular disease (CVD). And over a period of 8.46 years, 1974 subjects with prediabetes died, with 616 cases due to CVD. The multivariable-adjusted hazard ratios (HRs) comparing high to low tertile of NLR in diabetes subjects were found to be 1.37 (95% CI, 1.19–1.58) for all-cause mortality and 1.63 (95% CI, 1.29–2.05) for CVD mortality. And the correlation between high to low NLR tertile and heightened susceptibility to mortality from any cause (HR, 1.21; 95% CI, 1.03–1.43) and CVD mortality (HR, 1.49; 95% CI, 1.08–2.04) remained statistically significant (both p-values for trend < 0.05) in prediabetes subjects. The 10-year cumulative survival probability was determined to be 70.34%, 84.65% for all-cause events, and 86.21%, 94.54% for cardiovascular events in top NLR tertile of diabetes and prediabetes individuals, respectively. Furthermore, each incremental unit in the absolute value of NLR was associated with a 16%, 12% increase in all-cause mortality and a 25%, 24% increase in cardiovascular mortality among diabetes and prediabetes individuals, respectively. Conclusions The findings of this prospective cohort study conducted in the US indicate a positive association of elevated NLR levels with heightened risks of overall and cardiovascular mortality among adults with diabetes and prediabetes. However, potential confounding factors for NLR and the challenge of monitoring NLR’s fluctuations over time should be further focused.

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Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis

Cited by 3 publications

References 52 publications

Association between blood inflammatory indicators and prognosis of papillary thyroid carcinoma: a narrative review

Association between blood inflammatory indicators and prognosis of papillary thyroid carcinoma: a narrative review

Development of machine learning models to predict papillary carcinoma in thyroid nodules: The role of immunological, radiologic, cytologic and radiomic features

Association of neutrophil-lymphocyte ratio with all-cause and cardiovascular mortality in US adults with diabetes and prediabetes: a prospective cohort study

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