Preoperative Systemic Inflammation and Infectious Complications After Resection of Colorectal Liver Metastases

Abstract

Background: Postoperative complications are associated with a poor long-term prognosis after resection of colorectal liver metastases via an undetermined mechanism. The preoperative systemic inflammatory response, itself a predictor of poor survival, was recently shown to independently predict postoperative infectious complications after primary colorectal cancer resection. Objective: To examine the association of postoperative infectious complications with preoperative systemic inflammation and survival in patients undergoing resection of colorectal liver metastases. Design: Retrospective study based on a prospectively updated database. Setting: A United Kingdom tertiary referral hepatobiliary unit.

The value of the pretreatment neutrophil lymphocyte ratio vs. platelet lymphocyte ratio in predicting the long-term survival in colorectal cancer

“…Our results were matching some of the previously published studies that evaluated the prognostic value of NLR in CRC (Table 6) [7][8][9][10][11][15][16][17][18][19][20][21][22][23][24][25]. Among these 16 prior studies, eleven studies [8,9,11,[15][16][17][18]21,22,24,25] demonstrated that elevated NLR was a significant predictor of poor outcome in both univariate and multivariate analyses, four studies [7,10,19,23] had NLR as a significant predictor only in the univariate analysis and one study [20] did not find prognostic value of NLR but reported an association between elevated NLR and inflammatory markers.…”

“…Among these 16 prior studies, eleven studies [8,9,11,[15][16][17][18]21,22,24,25] demonstrated that elevated NLR was a significant predictor of poor outcome in both univariate and multivariate analyses, four studies [7,10,19,23] had NLR as a significant predictor only in the univariate analysis and one study [20] did not find prognostic value of NLR but reported an association between elevated NLR and inflammatory markers. While some of the prior studies used either cohort of AJCC stage II [11,15] or IV [9,17,21,22] to evaluate the predictive value of NLR, however, we found that the negative impact of elevated NLR was independent of cancer stage according to the multivariate analysis.…”

Preoperative peripheral blood neutrophil count predicts long-term outcomes following hepatic resection for colorectal liver metastases

“…This result indicates that neutrophil counts may themselves be an inflammatory and prognostic marker. Neal et al (24) demonstrated that the neutrophil count had a greater predictive value on long-term outcomes compared with NLR, when the multivariate Cox proportional regression model analyzed factors.…”

“…Additionally, systemic inflammation also induces the suppression of antitumor immunity by recruitment of regulatory T cells and activation of cytokines (25). Preoperative systemic inflammation and an immunosuppressive state may increase the risk of postoperative infectious complications, which influence long-term outcomes in patients with CRLM (24,28).…”

Preoperative neutrophil-to-lymphocyte ratio and tumor-related factors to predict lymph node metastasis in patients with pancreatic ductal adenocarcinoma (PDAC)

“…Since 2005, many studies have already been aware of the predictive value of the systemic inflammatory response in the outcome of patients undergoing resection for pancreatic cancer [18-21]. Neutrophil, one of the most important part of WBCs in the systemic inflammatory response, have been recognized as key participator for metastasis based on increasing evidence [22-25].…”