Preoperative staging of renal cell carcinoma using magnetic resonance imaging: comparison with pathological staging

Špero, Martina; Brkljačić, Boris; Kolarić, Branko; Marotti, Miljenko

doi:10.1016/j.clinimag.2009.09.005

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…Both MDCT and MRI perform highly in the T-staging of local tumour extent but perform poorly in N-staging. [9] In our study, κ test revealed excellent agreement between MRI, intraoperative staging and pathological staging which is consistent with the results of Kamel et al and Spero M et al [1011] who reported 80–85% accuracy of the MRI in staging organ confined renal cell carcinoma, as well as Ergen et al [12] who reported good agreement between MRI and pathological staging for T and M staging and poor for N staging.…”

Section: Discussionsupporting

confidence: 91%

Role of MRI in staging and surgical planning and its clinicopathological correlation in patients with renal cell carcinoma

Lal

Singh

Jain

et al. 2019

Indian Journal of Radiology and Imaging

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Background and Aims:Radiological evaluation of renal cell carcinoma (RCC) is used for non-invasive staging for better surgical planning. However, the correlation of radiological staging using magnetic resonance imaging (MRI) with histopathological findings has not been done so far. The aim of this study is to assess the role of MRI in pre-operative staging of RCC in patients undergoing radical nephrectomy and nephron sparing surgery (NSS) and correlate it with histopathological findings.Settings and Design:This prospective observational study was conducted from February 2015 to October 2016 at a tertiary care hospital in northern India.Methods:MR imaging was done on 3 Tesla MR scanner (Signa Hdxt General Electrics, Milwaukee, USA). Preoperative staging was based on 2010 TNM staging system. The preoperative parameters in MRI were tumor size, detection/breach of pseudocapsule, tumor extension into perirenal fat and detection of tumor venous thrombus. The staging on MRI was compared with surgical and pathological staging.Statistical Analysis Used:The agreement between these three staging methods was determined using the kappa statistics (0.0-0.2, poor; 0.2-0.4, fair; 0.4-0.6, moderate; 0.6-0.8, good; 0.8-1.0, excellent).Results:30 patients with suspected RCC underwent NSS (n = 10) and radical nephrectomy (n = 20). Mean tumor size was 9.66 ± 2.99 cm in the radical nephrectomy group and 4.06 ± 1.16 cm in the NSS group. There was perfect agreement between MRI, surgical and pathological staging for breach of pseudocapsule (κ =1.0, Percentage of Agreement = 100%, P < 0.05). In none of the patients, MRI missed extension beyond the Gerota's fascia or presence of venous thrombus.Conclusion:MRI staging of RCC is an accurate predictor of the surgical and pathological stage and has the potential to become a useful tool for preoperative identification of patients with RCC who can undergo NSS.

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Section: Discussionsupporting

confidence: 91%

Role of MRI in staging and surgical planning and its clinicopathological correlation in patients with renal cell carcinoma

Lal

Singh

Jain

et al. 2019

Indian Journal of Radiology and Imaging

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“…29 However, the ability to predict using imaging whether the tumor is organ-confined is limited even though for some authors, preoperative magnetic resonance imaging could help for pT2/pT3 tumor discrimination. 30 Decision at final pathology to perform an RN depends on associate factors such as age, comorbidities, renal function, surgical margins status, and tumor grade.…”

Section: Pierre Bigot Et Almentioning

confidence: 99%

Nephron-Sparing Surgery for Renal Tumors Measuring More Than 7 cm: Morbidity, and Functional and Oncological Outcomes

Bigot

Hétet

Bernhard

et al. 2014

Clinical Genitourinary Cancer

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“…[2] MRI is an extensively used non-invasive medical imaging technique which utilizes the property of nuclear magnetic resonance (NMR) to image water protons inside a human body. The MRI technique has long been used in renal cancer detection, [3][4][5][6] preoperative renal cancer staging, [7][8][9][10][11][12] and treatment evaluation of renal cancers. [13] Among a variety of MR techniques, T * 2 weighted (T * 2 W) MRI has been used to reveal not only functional but also morphological characteristics of renal diseases by taking advantage of differences in tissue properties such as the blood oxygen level and magnetic susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of similarity coefficient map for improving morphological evaluation ofT₂* weighted MRI for renal cancer

Wang

Xie

et al. 2013

Chinese Phys. B

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The purpose of this paper is to investigate the feasibility of using a similarity coefficient map (SCM) in improving the morphological evaluation of T2* weighted (T2*W) magnatic resonance imaging (MRI) for renal cancer. Simulation studies and in vivo 12-echo T2*W experiments for renal cancers were performed for this purpose. The results of the first simulation study suggest that an SCM can reveal small structures which are hard to distinguish from the background tissue in T2*W images and the corresponding T2* map. The capability of improving the morphological evaluation is likely due to the improvement in the signal-to-noise ratio (SNR) and the carrier-to-noise ratio (CNR) by using the SCM technique. Compared with T2*W images, an SCM can improve the SNR by a factor ranging from 1.87 to 2.47. Compared with T2* maps, an SCM can improve the SNR by a factor ranging from 3.85 to 33.31. Compared with T2*W images, an SCM can improve the CNR by a factor ranging from 2.09 to 2.43. Compared with T2* maps, an SCM can improve the CNR by a factor ranging from 1.94 to 8.14. For a given noise level, the improvements of the SNR and the CNR depend mainly on the original SNRs and CNRs in T2*W images, respectively. In vivo experiments confirmed the results of the first simulation study. The results of the second simulation study suggest that more echoes are used to generate the SCM, and higher SNRs and CNRs can be achieved in SCMs. In conclusion, an SCM can provide improved morphological evaluation of T2*W MR images for renal cancer by unveiling fine structures which are ambiguous or invisible in the corresponding T2*W MR images and T2* maps. Furthermore, in practical applications, for a fixed total sampling time, one should increase the number of echoes as much as possible to achieve SCMs with better SNRs and CNRs.

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Preoperative staging of renal cell carcinoma using magnetic resonance imaging: comparison with pathological staging

Cited by 8 publications

References 20 publications

Role of MRI in staging and surgical planning and its clinicopathological correlation in patients with renal cell carcinoma

Role of MRI in staging and surgical planning and its clinicopathological correlation in patients with renal cell carcinoma

Nephron-Sparing Surgery for Renal Tumors Measuring More Than 7 cm: Morbidity, and Functional and Oncological Outcomes

Feasibility of similarity coefficient map for improving morphological evaluation ofT₂* weighted MRI for renal cancer

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Preoperative staging of renal cell carcinoma using magnetic resonance imaging: comparison with pathological staging

Cited by 8 publications

References 20 publications

Role of MRI in staging and surgical planning and its clinicopathological correlation in patients with renal cell carcinoma

Role of MRI in staging and surgical planning and its clinicopathological correlation in patients with renal cell carcinoma

Nephron-Sparing Surgery for Renal Tumors Measuring More Than 7 cm: Morbidity, and Functional and Oncological Outcomes

Feasibility of similarity coefficient map for improving morphological evaluation ofT2* weighted MRI for renal cancer

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Feasibility of similarity coefficient map for improving morphological evaluation ofT₂* weighted MRI for renal cancer