Preoperative serum levels of serum VEGF-C is associated with distant metastasis in colorectal cancer patients

Alabi, Andrew; Suppiah, Aravind; Madden, Leigh A.; Monson, J. R. T.; Greenman, John

doi:10.1007/s00384-008-0622-x

Cited by 17 publications

(18 citation statements)

References 31 publications

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“…Hence, circulating VEGF-C and VEGF-D levels per se were not related to LNM. Although this finding is in accordance with reports on gastric [23], colorectal [24,25], and cervical [26] cancer, the pattern could be due to methodological factors. The nodal status of our patients was relatively scattered (Table I); however, a potential correlation of serum VEGF-C and VEGF-D to LNM may require a larger sample size to become evident.…”

Section: Discussionsupporting

confidence: 62%

Predictive significance of preoperative serum VEGF‐C and VEGF‐D, independently and combined with Ca19‐9, for the presence of malignancy and lymph node metastasis in patients with gastric cancer

Tsirlis

Kostakis

Papastratis

et al. 2010

Journal of Surgical Oncology

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Section: Discussionsupporting

confidence: 62%

Predictive significance of preoperative serum VEGF‐C and VEGF‐D, independently and combined with Ca19‐9, for the presence of malignancy and lymph node metastasis in patients with gastric cancer

Tsirlis

Kostakis

Papastratis

et al. 2010

Journal of Surgical Oncology

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“…Specifically, colorectal cancer, which also metastasises to the liver, is associated with a poor prognosis based on peri-operative serum VEGF levels 18 19. Osteosarcoma is associated with a poor prognosis in patients with serum VEGF levels greater than 1000 pg/ml 20 21.…”

Section: Discussionmentioning

confidence: 99%

Serum vascular endothelial growth factor (VEGF) levels correlate with number and location of micrometastases in a murine model of uveal melanoma

Crosby

Yang

Gao

et al. 2010

British Journal of Ophthalmology

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BackgroundA preliminary animal study was performed to determine if hepatic micrometastases from uveal melanoma secrete vascular endothelial growth factor (VEGF) that is measurable in serum.MethodsWe analysed the serum of a C57Bl/6 mouse model of uveal melanoma (n=10) at days 4, 7, 14 and 21 post-inoculation for VEGF levels. We compared the serum VEGF levels with the number and location of hepatic micrometastases and their respective expression of VEGF mRNA.ResultsSerum VEGF levels rose after inoculation of C57Bl/6 mice eyes with B16LS9 cutaneous melanoma cells. Beginning on day 14 there was a statistically significant (p<0.05) increase in VEGF levels, rising to an average peak level of 37.985 pg/ml at day 21. Peak serum VEGF levels correlated with the total number of hepatic micrometastases (R=0.444) and there was moderate correlation of peak VEGF serum levels with micrometastases in more hypoxic locations (R=0.572). VEGF mRNA expression by micrometastases was highest in the most hypoxic regions of the hepatic lobule.ConclusionsHepatic micrometastastic melanoma arising in a mouse model of ocular melanoma secretes VEGF. The number and location of the micrometastases correlate with serum VEGF levels.

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“…20,26,27 Serum VEGF C concentrations from 90 to 150 pg/ml have also been demonstrated in studies of metastatic colorectal carcinoma, although serum VEGF C concentrations associated with cancer vary widely in the literature. 28 Thus, it is plausible that an increase of VEGF C concentrations from 700 to 1,400 pg/ml could have a negative impact on the natural history of breast cancer.…”

Section: Anesthesiology V 113 • No 5 • November 2010 1121mentioning

confidence: 99%

Effect of Anesthetic Technique on Serum Vascular Endothelial Growth Factor C and Transforming Growth Factor β in Women Undergoing Anesthesia and Surgery for Breast Cancer

2010

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Background:In breast cancer, vascular endothelial growth factor C, transforming growth factor ␤, placental growth factor, and fibroblast growth factor (acidic and basic) promote angiogenesis and metastases. We tested the hypothesis that a propofol-paravertebral anesthetic (PPA) technique would attenuate postoperative changes in these angiogenic factors to a greater extent than balanced general anesthesia (GA) and morphine analgesia in women undergoing surgery for primary breast cancer. Method: Forty women with primary breast cancer undergoing surgical excision were randomized to receive either standard GA or PPA technique. Venous blood was sampled before and at 24 h after surgery and serum analyzed. The primary endpoint was a preoperative versus postoperative change in vascular endothelial growth factor C and transforming growth factor ␤ concentrations. Results: Using a visual analog scale (median [25-75% interquartile range]), PPA patients (1 [0 -2]) had less pain at 2 h (P ϭ 0.02) than did GA patients (3 [2-5]). The mean postoperative change in vascular endothelial growth factor C concentrations among GA patients was 733 versus 27 pg/ml for PPA patients (difference, 706 [97.5% CI,130] pg/ml, P ϭ 0.001). In contrast, the mean postoperative change in transforming growth factor ␤ concentration among GA patients was Ϫ163 versus 146 pg/ml for PPA patients (difference, 309 [97.5% CI, Ϫ474 to Ϫ143] pg/ml, P ϭ 0.005). Concentrations of placental growth factor and fibroblast growth factor, both acidic and basic, were undetectable in serum. Conclusion:Anesthetic technique influences serum concentrations of factors associated with angiogenesis in primary breast cancer surgery. BREAST cancer remains a leading cause of death among women and is second only to lung cancer as a cause of cancer mortality in western countries, most of which is attributable to recurrence and metastasis. Breast cancer also accounts for more new cases of cancer among women than any other cancer.1 Initial treatment almost invariably involves surgical excision. However, tumor recurrence occurs in a significant number of patients. Even when the most experienced operator performs surgical resection, it is unavoidable that tumor cells are dispersed into the blood and lymphatic circulations. 2 The fate of this small burden of tumor cells depends on the balance between antimetastatic factors and the ability of the tumor to invade, propagate, and metastasize.3

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Preoperative serum levels of serum VEGF-C is associated with distant metastasis in colorectal cancer patients

Abstract: In this study, low sVEGF-C levels are associated with distant metastasis; hence, preoperative levels may aid in the selection of CRC patients who require further investigation.

Cited by 17 publications

References 31 publications

Predictive significance of preoperative serum VEGF‐C and VEGF‐D, independently and combined with Ca19‐9, for the presence of malignancy and lymph node metastasis in patients with gastric cancer

Predictive significance of preoperative serum VEGF‐C and VEGF‐D, independently and combined with Ca19‐9, for the presence of malignancy and lymph node metastasis in patients with gastric cancer

Serum vascular endothelial growth factor (VEGF) levels correlate with number and location of micrometastases in a murine model of uveal melanoma

Effect of Anesthetic Technique on Serum Vascular Endothelial Growth Factor C and Transforming Growth Factor β in Women Undergoing Anesthesia and Surgery for Breast Cancer

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