Preoperative serum high-density lipoprotein cholesterol as a predictor of poor survival in patients with clear cell renal cell cancer

Abstract

Purpose: Numerous studies have suggested that dyslipidemia is closely related to various cancers and the high-density lipoprotein cholesterol (HDL-C) levels are associated with the outcome of cancer patients. However, the predictive value of HDL-C in patients with renal cell carcinoma remains unclear. Our study aims to explore the relationship between the levels of serum HDL-C and the prognosis of renal cell carcinoma. Methods: A total of 308 patients diagnosed with clear cell renal cell carcinoma (CCRCC) who received surgical treatment were retrospectively enrolled in our study. The necessary clinical data of each enrolled patient were collected and the Kaplan–Meier method and the Cox proportional hazards regression model were used to calculate the overall survival and cancer-specific survival. Results: Kaplan–Meier and univariate analysis showed that a lower preoperative serum HDL-C level was a risk factor of CCRCC patients. Multivariate analyses demonstrated that a higher serum HDL-C level was closely associated with better overall survival (hazard ratio = 0.32; 95% confidence interval (0.13, 0.78); P=0.013) and cancer-specific survival (hazard ratio =0.42; 95% confidence interval (0.15, 0.99); P=0.048). Conclusion: Our findings suggest that an increased serum level of HDL-C might predict better overall survival and cancer-specific survival in patients with CCRCC.

[Retracted] A New Survival Model Based on Cholesterol Biosynthesis‐Related Genes for Prognostic Prediction in Clear Cell Renal Cell Carcinoma

“…Many studies have shown that preoperative cholesterol levels in cancer patients can influence postoperative prognosis, and cholesterol level has been used to construct a model to predict patient survival [11][12][13][14]. Cholesterol accumulation is a common feature of cancer tissue, and recent studies have shown that it plays an important role in breast, bladder, colorectal, and other cancers [15]. The mechanism of cholesterol metabolism in cells has been largely understood through current studies.…”

Immune cell-lipoprotein imbalance as a marker for early diagnosis of non-small cell lung cancer metastasis

“…Many cancers lead to metabolic disorders in the body, and disorders of lipid metabolism have been reported to play a key role in the pathogenesis of cancer. Studies have found correlations between serum lipids and many types of tumors such as breast cancer and gastric cancer ( 20 ). High-density lipoprotein cholesterol, a serum lipid, has been shown to correlate with tumor incidence and mortality ( 21 ).…”

Preoperative serum low-density lipoprotein cholesterol is an independent prognostic factor in patients with renal cell carcinoma after nephrectomy

“…Serum TC and HDL-C levels have been reported to be associated with the prognosis in RCC patients [ 24 , 25 ]. This is the first study that demonstrated the association between preoperative LDL-C levels and the prognosis of RCC patients after nephrectomy.…”

“…Moreover, LDL-C can promote the proliferation and migration of cancer cells [ 22 , 23 ]. Recently, high-density lipoprotein cholesterol (HDL-C) and total cholesterol (TC) have been considered independent factors for the prognosis of RCC patients [ 24 , 25 ]. However, little is known about the prognostic value of LDL-C in RCC patients.…”