Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment

Sun, Lulu; Chu, Koung‐Shing; Cheng, Su-Chen; Lu, Chien‐Yu; Kuo, Chao‐Hung; Hsieh, Jan-Sing; Shih, Yuh-Chuan; Chang, Shun‐Jen; Wang, Jaw‐Yuan

doi:10.1186/1471-2407-9-288

Cited by 89 publications

(74 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The serum albumin is a simple estimation of the visceral protein and is one of the best parameters to assess the nutritional condition. Several studies have found an association between serum albumin concentration and in-hospital mortality (16)(17)(18), postoperative complications (18,19), duration of hospitalization (18,20), quality of life (21) and prognosis in cancer patients (22)(23)(24)(25). Patients from the screening program had a better nutritional status based on preoperative serum albumin levels.…”

Section: Discussionmentioning

confidence: 99%

The impact of screening on short-term outcome after surgery for colorectal cancer

Sebastian¹,

Courtier²,

Macià³

et al. 2017

Rev Esp Enferm Dig

View full text Add to dashboard Cite

Aim: To investigate the influence of a screening program on the short-term outcome of patients undergoing surgery for colorectal cancer.Methods: Between April 2010 and December 2012 patients diagnosed with colorectal cancer via the screening program (n = 80) were compared with patients diagnosed elsewhere (n = 106). Only patients of ≥ 50 and ≤ 69 years of age diagnosed outside the program were selected as controls. The clinical variables included age, sex, American Society of Anesthesiologists (ASA) status, Charlson index, preoperative hemoglobin and serum albumin levels, surgical approach, tumor location and stage, perioperative transfusion and postoperative morbidity. A multivariate analysis was used to identify variables independently associated with outcome.Results: There were no significant differences with regard to age, sex and ASA status. Preoperative hemoglobin (14.1 ± 1.6 g/ dl vs 12.3 ± 2.3 g/dl; p < 0.001) and serum albumin (4.45 ± 0.26 g/dl vs 4.0 ± 0.6 g/dl; p < 0.001) levels were significantly higher in the screening group. The overall morbidity was significantly lower in the screening group (38.8% vs 63.2; p < 0.001) and mainly related to a higher rate of Clavien-Dindo grade II complications in controls. There were no differences with regard to wound infection, postoperative ileus, anastomotic leakage or reoperations. The median length of hospital stay was shorter in the screening group (6 vs 9 days; p = 0.003). Multivariate analysis showed that diagnosis outside the screening program, type of surgical procedure, open surgery and Charlson index were independent risk factors for postoperative complications.Conclusions: The diagnosis of colorectal cancer via the screening program is associated with a lower rate of postoperative minor complications and a shorter hospital stay.

show abstract

Section: Discussionmentioning

confidence: 99%

The impact of screening on short-term outcome after surgery for colorectal cancer

Sebastian¹,

Courtier²,

Macià³

et al. 2017

Rev Esp Enferm Dig

View full text Add to dashboard Cite

show abstract

“…Some studies reported that the pre-operative CEA level was an independent prognostic factor affecting the CRC survival (Sun et al, 2009;Chew et al, 2012;He et al, 2014). A study reported that the survival decreased among patients with high pre-operative CEA levels and that the pre-operative CEA was correlated with tumor, tumor invasion depth, lymph node condition, stage, and post-operative recurrence (Wang et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…A study reported that the survival decreased among patients with high pre-operative CEA levels and that the pre-operative CEA was correlated with tumor, tumor invasion depth, lymph node condition, stage, and post-operative recurrence (Wang et al, 2007). Many studies reported that when evaluated together, CEA and CA 19-9 levels increase sensitivity and specificity and that high levels indicate poor prognosis, where PFS and OS decreased significantly (Dixon et al, 2003;Wang et al, 2007;Sun et al, 2009;Dong et al, 2013;Sisik et al, 2013). Some studies conducted on CA 19-9 reported that it was of greater sensitivity than CEA in case of advanced stage diseases (Wang et al, 2002;Mourtzikou et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Prognosis in Metastatic Colorectal Cancer Patients

Eker¹,

Özaslan²,

Karaca³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…To date, a number of studies have been extensively conducted to explore the role of pre-operative prognostic factors for survival in patients with CRC. In particular, neutrophil:lymphocyte ratio (NLR) [7,8], pre-operative albumin [9,10], and haemoglobin [11,12] were shown to be useful prognostic indicators. This study aims to investigate if these prognostic factors of CRC also influence the length of postoperative stay following colorectal excisional surgery.…”

Section: Introductionmentioning

confidence: 99%

Pre-operative Serum Albumin and Neutrophil-Lymphocyte Ratio are Associated with Prolonged Hospital Stay Following Colorectal Cancer Surgery

Gohil

Rishi

Tan

2014

BJMMR

View full text Add to dashboard Cite

Aims-Colorectal cancer is the third most common cancer in European populations. It has been shown previously that neutrophil-lymphocyte ratio (NLR), pre-operative albumin, and haemoglobin are useful prognostic indicators. The aim of this study was to assess how these factors influence the length of postoperative stay (LOS) following colorectal cancer surgery.Methodology-All patients undergoing elective colorectal resections for malignancy between 2010 and 2011 in Pilgrim Hospital, Boston, U.K. were considered for the study. Hospital archive systems were used to ascertain pre-operative NLR, albumin and haemoglobin levels. LOS was calculated from electronic discharge documents with day 1 being the day after surgery. Unifactorial and multifactorial analyses were performed to identify independent predictors of prolonged stay Results-196 patients were included in the study. Pre-operative haemoglobin was not associated with prolonged hospital stay. On univariate analysis, pre-operative serum albumin and preoperative NLR were associated with prolonged hospital stay. On multivariate analysis, preoperative serum albumin >34.5 g/dl (odds ratio, 0.47; 95% confidence interval, 0.24 -0.92; p = 0.027) retained independent association for prolonged hospital stay .However, pre-operative NLR failed to reach statistical significance on multivariate analysis.Conclusions-Patients with low albumin and elevated NLR are more likely to have an increased hospital stay following colorectal cancer surgery. This may be useful for surgeons in terms of identifying the 'high-risk' patient post-operatively and allow for early intervention. *Corresponding author: benjamintan@hotmail.co.uk. AUTHORS' CONTRIBUTIONSBT designed the study and performed the statistical analysis. RG collected the data, managed the analyses of the study and wrote the first draft of the manuscript. MR collected the data, managed the analyses of the study. All authors read and approved the final manuscript. COMPETING INTERESTSAuthors have declared that no competing interests exist. Europe PMC Funders Group

show abstract

Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment

Cited by 89 publications

References 23 publications

The impact of screening on short-term outcome after surgery for colorectal cancer

The impact of screening on short-term outcome after surgery for colorectal cancer

Factors Affecting Prognosis in Metastatic Colorectal Cancer Patients

Pre-operative Serum Albumin and Neutrophil-Lymphocyte Ratio are Associated with Prolonged Hospital Stay Following Colorectal Cancer Surgery

Contact Info

Product

Resources

About