Preoperative serum albumin is associated with intra‐abdominal infection following major hepatectomy

Rungsakulkij, Narongsak; Vassanasiri, Watoo; Tangtawee, Pongsatorn; Suragul, Wikran; Muangkaew, Paramin; Mingphruedhi, Somkit; Aeesoa, Suraida

doi:10.1002/jhbp.673

Cited by 20 publications

(21 citation statements)

References 39 publications

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“…It was found that patients who have intraabdominal infection have significantly longer operative time than those in a non-intraabdominal infection group. 28 This is consistent with Chacon et al, who studied the effect of operative duration and infectious complications and mortality in a large population of patients who underwent hepatectomy. 30 It was found that an operative time greater than 3 h significantly increased mortality, with a considerable peak at 8 h. Furthermore, as the 30-day mortality rate increased in accordance with the operative time, it was concluded that operative time is associated with a linear increase of risk of mortality and infectious complications following hepatectomy.…”

Section: Discussionsupporting

confidence: 89%

“…First, with respect to duration of surgery, a prolonged operative time is associated with major morbidity and mortality, as previously reported. 28 , 29 In earlier study, we reported the factors associated with infectious complications in patients who underwent major hepatectomy were reported. It was found that patients who have intraabdominal infection have significantly longer operative time than those in a non-intraabdominal infection group.…”

Section: Discussionmentioning

confidence: 99%

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Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy

et al. 2021

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Objective: The objective of this study was to examine the relationship between the rate of bilirubin decrease following preoperative biliary drainage before pancreaticoduodenectomy and postoperative morbidity. Methods: Records of patients who underwent pancreaticoduodenectomy at the Department of Surgery in Ramathibodi Hospital between January 2008 and December 2019 were retrospectively reviewed. The patients were classified into either an adequate or inadequate drainage rate groups according to the bilirubin decrease rate. Major morbidity was defined as higher than grade II in the Clavien-Dindo classification. Risk factors for major morbidity were analyzed by logistic regression analysis. Results: In total, 166 patients were included in the study. Major morbidity was observed in 36 patients (21.6%). Adequate biliary drainage rate was observed in 39 patients (23.4%). Patients who had major morbidity were less likely to have come from the adequate biliary drainage rate group than the inadequate group (38.9% vs. 61.1%). However, through multivariate logistic analysis, only body mass index, operative time, and pancreatic duct diameter were independent factors associated with major morbidity, whereas the bilirubin decrease rate was not. Conclusions: Bilirubin decrease rate following preoperative biliary drainage has no significant association with major postoperative morbidity after pancreaticoduodenectomy.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy

et al. 2021

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“…Nutritional therapy is fundamental to the treatment of patients with severe infection and can directly affect the prognosis of patients with IAI. A study by Rungsakulkij et al showed that hypoproteinemia before abdominal surgery was associated with an increased risk of postoperative IAI ( 19 ). Moreover, according to a systematic review conducted by Alharbi et al, hypoproteinemia increases the risk of peritonitis in patients undergoing peritoneal dialysis ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Predictive Scoring System for In-hospital Death in Patients With Intra-Abdominal Infection: A Single-Center 10-Year Retrospective Study

Xue¹,

Liang

et al. 2021

Front. Med.

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Objective: To develop and validate a scoring system to predict the risk of in-hospital death in patients with intra-abdominal infection (IAI).Materials and Methods: Patients with IAI (n = 417) treated at our hospital between June 2010 and May 2020 were retrospectively reviewed. Risk factors for in-hospital death were identified by logistic regression analysis. The regression coefficients of each risk factor were re-assigned using the mathematical transformation principle to establish a convenient predictive scoring system. The scoring system was internally validated by bootstrapping sample method.Results: Fifty-three (53/417, 12.7%) patients died during hospitalization. On logistic regression analysis, high APACHE II score (P = 0.012), pneumonia (P = 0.002), abdominal surgery (P = 0.001), hypoproteinemia (P = 0.025), and chronic renal insufficiency (P = 0.001) were independent risk factors for in-hospital death. On receiver operating characteristic curve analysis, the composite index combining these five risk factors showed a 62.3% sensitivity and 80.2% specificity for predicting in-hospital death (area under the curve: 0.778; 95% confidence interval: 0.711–0.845, P < 0.001). The predictive ability of the composite index was better than that of each independent risk factor. A scoring system (0–14 points) was established by re-assigning each risk factor based on the logistic regression coefficient: APACHE II score (10–15 score, 1 point; >15 score, 4 points); pneumonia (2 points), abdominal surgery (2 points), hypoproteinemia (2 points), and chronic renal insufficiency (4 points). Internal validation by 1,000 bootstrapping sample showed relatively high discriminative ability of the scoring system (C-index = 0.756, 95% confidence interval: 0.753–0.758).Conclusions: The predictive scoring system based on APACHE II score, pneumonia, abdominal surgery, hypoproteinemia, and chronic renal insufficiency can help predict the risk of in-hospital death in patients with IAI.

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“…Intra-abdominal infections vary in severity and prognosis. Preoperative weight loss, obesity, liver cirrhosis, long operation time, low serum albumin (ALB) level, and long drainage tube indwelling time are all independent risk factors for intra-abdominal infection, [13][14][15][16] and in patients with abdominal infection However, there are few reports on the factors affecting the prognosis of intra-abdominal infection and the evaluation value of these factors on the prognosis. This article aims to explore the distribution of pathogenic bacteria in patients with intra-abdominal infection, clarify the independent factors affecting the prognosis of patients with intra-abdominal infection and their prognostic evaluation value, clinically screen patients with poor prognosis and high-risk patients, to implement timely and effective targeted treatment and improve patient prognosis.…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing the Prognosis of Patients with Intra-Abdominal Infection and Its Value in Assessing Prognosis

Pan

Zhu

Zhang

et al. 2021

IDR

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To explore the distribution of pathogenic bacteria in patients with intra-abdominal infection, to clarify the independent factors that affect the prognosis of patients with intraabdominal infection and its evaluation value for prognosis. Patients and Methods: The pathogens, underlying diseases, and related clinical data of patients with intra-abdominal infection from January 2012 to December 2019 in our hospital were retrospectively collected and the APACHE II score was calculated. The patients were divided into survival group and death group according to the prognosis, and the index between the two groups was compared. Spearman correlation analysis was used to evaluate the correlation between each index and prognosis, multivariate logistic regression analysis was used to screen the independent prognostic factors. Results: Spearman correlation analysis showed that ALB level was negatively correlated with prognosis, age and APACHE II score were positively correlated with prognosis. Logistic regression analysis showed that age, ALB level, and APACHE II score were independent prognostic factors. The formula of age combined ALB level and APACHE II score was Y = X1-3.6X2 + 6.5X3 (X1 was the age, X2 was the ALB level and X3 was the APACHE II score), Y was positively correlated with poor prognosis, and the optimal cutoff value was Y = 40.96. Conclusion: Age, ALB level, and APACHE II score are independent factors that influencing the prognosis of patients with intra-abdominal infection, and the combination of age, ALB level, and APACHE II score can better assess the prognosis of patients with intraabdominal infection.

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Preoperative serum albumin is associated with intra‐abdominal infection following major hepatectomy

Cited by 20 publications

References 39 publications

Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy

Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy

Development and Validation of a Predictive Scoring System for In-hospital Death in Patients With Intra-Abdominal Infection: A Single-Center 10-Year Retrospective Study

Factors Influencing the Prognosis of Patients with Intra-Abdominal Infection and Its Value in Assessing Prognosis

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