Preoperative Sensorimotor Mapping in Brain Tumor Patients Using Spontaneous Fluctuations in Neuronal Activity Imaged With Functional Magnetic Resonance Imaging

Zhang, Dongyang; Johnston, James M.; Fox, Michael; Leuthardt, Eric C.; Grubb, Robert L.; Chicoine, Michael R.; Smyth, Matthew D.; Snyder, Abraham Z.; Raichle, Marcus E.; Shimony, Joshua S.

doi:10.1227/01.neu.0000350868.95634.ca

Cited by 156 publications

(214 citation statements)

References 46 publications

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“…F-MRI is a non-invasive technique for examining brain function that utilizes changes in blood oxygenation to identify areas of increased or decreased neuronal activity. However, there are limitations because pre-operative localization is only as good as the patient's ability to perform the task or function one is attempting to localize 13 . Gonzáles et al found that despite preoperative planning for multimodal navigation, motor f-MRI and subcortical pathways generated by diffusion tensor imaging (DTI) of intrinsic brain tumors located in motor eloquent areas and intraoperative neuromonitorization, the mean volumetric resection was 89%.…”

Section: Discussionmentioning

confidence: 99%

Resection versus biopsy of glioblastomas in eloquent brain areas

Hrabálek¹,

Kalita²,

Vaverka³

et al. 2015

BIOMED PAP

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Aim. The aim of this study was to compare resection and biopsy of glioblastoma (GBM) in eloquent brain areas (EBA). Methods. This was a prospective evaluation of 38 patients with GBM in EBA. 22 were treated by surgical resection and 16 by biopsy. Preoperative KPS, neurological status and size of lesion on MRI were assessed. One week and three months postoperatively KPS, neurological status and Performance Status (PS) WHO were evaluated. Extent of resection (EOR) and overall survival (OS) were described. Overall mean age of the patients was 64.3 years, the mean lesion size in the resection group was 47.7 mm and in the biopsy group 51.0 mm. Results. Worsening or development of permanent neurological deficits 3 months after surgery were significantly lower in the resection group (23%), than the biopsy group (94%). In the resection group the median pre and postoperative KPS three months after surgery was 80.0. In the biopsy group the median pre and postoperative KPS was 68.1 one week after the procedure. In the resection group, 3 months after surgery, the median PS was 1, in the biopsy group one week after surgery the median PS was 2. The difference was statistically insignificant. The mean OS after resection was 12.2 months, and after biopsy 3.5 months. The difference was highly statistically significant. The mean EOR was 90%. Conclusion. This is the first prospective study, to our knowledge, that compares the results of resection and biopsy of primary GBM in EBA. For patients in good clinical condition with tumors in or near EBA, recommended is as radical resection of GBM as possible.

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Section: Discussionmentioning

confidence: 99%

Resection versus biopsy of glioblastomas in eloquent brain areas

Hrabálek¹,

Kalita²,

Vaverka³

et al. 2015

BIOMED PAP

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“…A region of interest is typically used as an initial seed to highlight the sensorimotor component of spontaneous activity, but this is always supplemented by ICA analysis, to remove anatomic assumptions that may be misleading in the presence of gross lesions and functional reorganization. 37 Another example is in the study of AD: Given that a central involvement of the hippocampus is expected, a ROI approach is well-motivated. 10 However, even for this application, ICA is frequently used because it reduces the risk of missing relevant activity also in other areas due to a priori anatomic assumptions.…”

Section: Discussionmentioning

confidence: 99%

Functional Connectivity during Resting-State Functional MR Imaging: Study of the Correspondence between Independent Component Analysis and Region-of-Interest−Based Methods

Rosazza¹,

Minati²,

Ghielmetti³

et al. 2011

AJNR Am J Neuroradiol

105

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“…These results suggest that an ICA-based approach with resting-state functional MR imaging may be sufficient to determine hemispheric language dominance. This study adds to the growing body of evidence to suggest that resting-state functional MR imaging can be potentially useful for presurgical mapping of eloquent cortices (4,6,(17)(18)(19)(20)(21)(22)(23) but that it is limited by methodologic differences among prior studies, small sample sizes of these studies, and the use of various reference techniques (eg, task-based functional MR imaging, electrocortical stimulation, IAP).…”

Section: Technical Developments: Resting-state Functional Mr Imaging mentioning

confidence: 99%

Resting-State Functional MR Imaging for Determining Language Laterality in Intractable Epilepsy

DeSalvo¹,

Tanaka²,

Douw

et al. 2016

Radiology

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Purpose:To measure the accuracy of resting-state functional magnetic resonance (MR) imaging in determining hemispheric language dominance in patients with medically intractable focal epilepsies against the results of an intracarotid amobarbital procedure (IAP). Materials and Methods:This study was approved by the institutional review board, and all subjects gave signed informed consent. Data in 23 patients with medically intractable focal epilepsy were retrospectively analyzed. All 23 patients were candidates for epilepsy surgery and underwent both IAP and resting-state functional MR imaging as part of presurgical evaluation. Language dominance was determined from functional MR imaging data by calculating a laterality index (LI) after using independent component analysis. The accuracy of this method was assessed against that of IAP by using a variety of thresholds. Sensitivity and specificity were calculated by using leave-one-out cross validation. Spatial maps of language components were qualitatively compared among each hemispheric language dominance group. Results:Measurement of hemispheric language dominance with resting-state functional MR imaging was highly concordant with IAP results, with up to 96% (22 of 23) accuracy, 96% (22 of 23) sensitivity, and 96% (22 of 23) specificity. Composite language component maps in patients with typical language laterality consistently included classic language areas such as the inferior frontal gyrus, the posterior superior temporal gyrus, and the inferior parietal lobule, while those of patients with atypical language laterality also included non-classical language areas such as the superior and middle frontal gyri, the insula, and the occipital cortex. Conclusion:Resting-state functional MR imaging can be used to measure language laterality in patients with medically intractable focal epilepsy.q RSNA, 2016

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Preoperative Sensorimotor Mapping in Brain Tumor Patients Using Spontaneous Fluctuations in Neuronal Activity Imaged With Functional Magnetic Resonance Imaging

Cited by 156 publications

References 46 publications

Resection versus biopsy of glioblastomas in eloquent brain areas

Resection versus biopsy of glioblastomas in eloquent brain areas

Functional Connectivity during Resting-State Functional MR Imaging: Study of the Correspondence between Independent Component Analysis and Region-of-Interest−Based Methods

Resting-State Functional MR Imaging for Determining Language Laterality in Intractable Epilepsy

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