Preoperative Sarcopenia Negatively Impacts Postoperative Outcomes Following Major Hepatectomy with Extrahepatic Bile Duct Resection

Abstract

This study demonstrated that preoperative sarcopenia increased the morbidity rate including the rate of liver failure, in patients who underwent major hepatectomy with extrahepatic bile duct resection.

Psoas muscle area is not representative of total skeletal muscle area in the assessment of sarcopenia in ovarian cancer

“…Although in some studies a correlation between PA and post‐operative complications was seen, the majority have failed to prove a relationship between PA‐assessed sarcopenia and survival 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23. Only few have actually assessed the agreement between PA and SMA within their population; Jones et al studied 100 patients with colorectal cancer and reported a Spearman correlation of 0.8 for PA and SMA and a Spearman correlation of 0.94 for PA and PLW, which could not be reproduced in our cohort 11.…”

“…This method has been used to predict surgical complications in different cancer types with contrasting results. PA has shown a correlation with post‐operative complications in individual studies on colorectal cancer, colorectal liver metastases, kidney cancer, bladder cancer, cholangiocarcinoma, and hepatocellular cancer,11, 12, 13, 14, 15, 16 while this effect was not seen in other pancreatic cancer, endometrial cancer, biliary cancer, or sarcoma studies 17, 18, 19, 20. Interestingly, only few cancer studies were able to show a correlation between PA and survival 21, 22, 23.…”

Sarcopenia is associated with severe postoperative complications in elderly gastric cancer patients undergoing gastrectomy

“…Sarcopenia, an important contributor to frailty in aging individuals, is a decline in muscle mass and physical function primarily induced by aging [5] and secondarily caused by malignancy [6]. It has previously been found to be associated with adverse postoperative outcomes after resection of colorectal cancer [12,13], pancreatic cancer [17], hepatocellular carcinoma [11,15], metastatic liver cancer [14], and perihilar cholangiocarcinoma [16]. In the current study, we demonstrated that sarcopenia is prevalent among elderly gastric cancer patients before surgery; calories and protein from food intake were insufficient in sarcopenic patients, and they had a higher incidence of severe postoperative complications.…”

“…Computed tomography (CT) imaging has been most frequently used to predict preoperative sarcopenia and investigate the relationship between sarcopenia and postoperative outcomes. However, methods for evaluating total mass of the psoas [14][15][16][17], SM [11][12][13]31], or total volume of the psoas major [15] and cutoff points for sarcopenia differ across studies because of the difficulty in comparing sarcopenic candidates to healthy young adults in term of radiation exposure. How to best characterize sarcopenia remains to be elucidated.…”

“…Recently, the influence of sarcopenia on treatment outcomes in cancer patients has been intensively investigated; sarcopenia was demonstrated to be independently associated with negative short-term [11][12][13][14][15][16][17][18] and long-term [11,[18][19][20] outcomes after surgery and an increased rate of chemotherapy-related toxicity [21][22][23].…”