Preoperative radiotherapy for initially inoperable extremity soft tissue sarcomas

Robinson, Martin; Ball, Adrian; Schofield, J. B.; Fisher, Cyril; Harmer, C.; Thomas, Joseph

doi:10.1016/s0936-6555(05)80772-1

Cited by 30 publications

(17 citation statements)

References 23 publications

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“…There have been few large series and most have included embryonal rhabdomyosarcomas which have a different natural history from other sarcomas and are both radio-and chemosensitive (Pratt, 1969). We (Robinson et al, 1992).…”

mentioning

confidence: 98%

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Head and neck sarcomas: prognostic factors and implications for treatment

Eeles

Fisher²,

A’Hern³

et al. 1993

Br J Cancer

164

116

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(Robinson et al., 1992).The following data were also collected: demographic factors, tumour stage (UICC), predisposing factors, treatment details, and local recurrence plus overall survival. Actuarial plots of survival and local recurrence-free rate, according to the above facors, were compared using log-rank analysis (Peto et al., 1977). Multivariate Cox regression analysis was carried out to determine the independent prognostic factors for survival and local recurrence (Cox, 1972). Death was not treated as an event when analysing local recurrence-free rate.

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mentioning

confidence: 98%

“…

(Robinson et al, 1992).The following data were also collected: demographic factors, tumour stage (UICC), predisposing factors, treatment details, and local recurrence plus overall survival. Actuarial plots of survival and local recurrence-free rate, according to the above facors, were compared using log-rank analysis (Peto et al, 1977).

…”

mentioning

confidence: 99%

Head and neck sarcomas: prognostic factors and implications for treatment

Eeles

Fisher²,

A’Hern³

et al. 1993

Br J Cancer

164

116

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“…Fein 1995 noted that patients receiving <62.5Gy had 5-year local control of 78% v 95% where the dose was >62.5Gy. (Robinson et al;1992) failed to demonstrate a variation in local control according to dose, although the response rate to pre-operative radiotherapy was clearly dose dependent.…”

Section: Adjuvant Radiotherapymentioning

confidence: 89%

Randomised trial of volume of post-operative radiotherapy given to adult patients with extremity soft tissue sarcoma

Robinson¹

2013

http://isrctn.org/>

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“…32 In o u r exp er ien ce, patien ts treated w ith pre-operative radiotherapy to doses over 60 Gy had up to 80% response rates. 34 The incidence of late m orbidity is greater with use of a high er total dose of radiotherapy and high er dose per fraction. In the series by Slater, m ajor com plications were increased in patients treated to 70 G y or m ore. 31 In a previous study perform ed at our centre, the degree of ® brosis was related to total dose of radiotherapy in patients treated for STS of the extremity.…”

Section: Discussionmentioning

confidence: 99%

Hyper‐Fractionated Radiotherapy for Soft Tissue Sarcoma: Results of theSecond Study of Hyper‐Fractionated Radiotherapy

Jacob

Gilligan

Robinson

et al. 1999

Sarcoma

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Purpose and Method. Hyper-fractionated radiotherapy for treatment of soft tissue sarcomas is designed to deliver a higher total dose of radiation without an increase in late normal tissue damage. In a previous study at the Royal Marsden Hospital, a total dose of 75 Gy using twice daily 1.25 Gy fractions resulted in a higher incidence of late damage than conventional radiotherapy using 2 Gy daily fractions treating to a total of 60 Gy. The current trial therefore used a lower dose per fraction of 1.2 Gy and lower total dose of 72 Gy, with 60 fractions given over a period of 6 weeks.Subjects. A total of 37 patients (22 males and 15 females) with a median age of 56 years (range 19-88 years) were treated.Results. Of eight patients treated pre-operatively, six showed a partial response and in two the tumour was static. The maximum acute toxicities were grade 1 in eight, grade 2 in 14 and grade 3 in 15 patients. Late toxicities of the skin were graded 1 in 10 and grade 2 in nine patients. Five patients complained of pain in the irradiated bone and soft tissues, which was of moderate severity (grade 2). Stiffness was graded 2 in three patients and severe (grade 3) in one.Three patients had moderate and one patient had severe lymphoedema following treatment. The 5-year recurrence-free survival probability of patients treated radically was 76%. Following excision of local recurrences the study group had a disease-free survival probability of 86% at 5 years.Discussion. The regime is well tolerated with comparable local control and late complication rates to standard daily fractionated therapy.The potential benefit of this regime needs to be defined in a prospective randomized trial.

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Preoperative radiotherapy for initially inoperable extremity soft tissue sarcomas

Cited by 30 publications

References 23 publications

Head and neck sarcomas: prognostic factors and implications for treatment

Head and neck sarcomas: prognostic factors and implications for treatment

Randomised trial of volume of post-operative radiotherapy given to adult patients with extremity soft tissue sarcoma

Hyper‐Fractionated Radiotherapy for Soft Tissue Sarcoma: Results of theSecond Study of Hyper‐Fractionated Radiotherapy

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