Preoperative pyuria predicts advanced pathologic tumor stage and worse survival in patients with urothelial carcinoma of the upper urinary tract treated by radical nephroureterectomy

Liang, Cui; Wang, Jinliang; Liu, Hailong; Huang, Liqun; Ding, Xu; Qian, Subo; Qian, Xiaoqiang; Qi, Jun

doi:10.1016/j.urolonc.2016.04.011

Cited by 9 publications

(8 citation statements)

References 30 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, a bacteria-associated immune response may suppress the initiation and development of bladder cancer, a response which might potentially be similar to an immune response caused by the intravesical instillation of bacillus Calmette-Guerin. A single retrospective study showed that preoperative pyuria was a significant predictor for higher pT stage and worse overall survival (OS) in patients with UTUC treated with RNU (21). In the present study, patients with preoperative pyuria had worse OS than those without (5-year OS: 85% vs. 76%, p=0.044, data not shown), corresponding with the finding of the previous study.…”

Section: Discussionsupporting

confidence: 90%

Effect of Preoperative Bacteriuria and Pyuria on Intravesical Recurrence in Patients with Upper Tract Urothelial Carcinoma Undergoing Radical Nephroureterectomy

Fukushima

Kobayashi

Kawano

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Effect of Preoperative Bacteriuria and Pyuria on Intravesical Recurrence in Patients with Upper Tract Urothelial Carcinoma Undergoing Radical Nephroureterectomy

Fukushima

Kobayashi

Kawano

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In UTUC, preoperative pyuria has also been reported as a prognostic biomarker. Liang et al [13] first reported the association between preoperative pyuria and UTUC prognosis. Their retrospective analysis indicated that preoperative pyuria was significantly associated with advanced pathologic T stage.…”

Section: Discussionmentioning

confidence: 99%

“…Pyuria, easily identified using low-cost non-invasive urine tests, reflects the inflammatory state of the urinary tract. Numerous studies have reported that pyuria is a significant prognostic factor in urothelial carcinomas [11][12][13][14][15]. However, to date, only a few studies have evaluated whether sterile pyuria can be a predictive factor for IVR [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies have reported that pyuria is a significant prognostic factor in urothelial carcinomas [11][12][13][14][15]. However, to date, only a few studies have evaluated whether sterile pyuria can be a predictive factor for IVR [12,13]. Thus, the purpose of this study was to evaluate if preoperative sterile pyuria can be a prognostic factor for IVR and overall survival (OS) in patients with UTUC undergoing surgery.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preoperative sterile pyuria as a prognosticbiomarker for intravesical recurrence in upperurinary tract urothelial carcinoma

et al. 2020

View full text Add to dashboard Cite

Purpose: To evaluate if preoperative sterile pyuria can be a prognostic factor for intravesical recurrence (IVR) and overall survival (OS) in patients with upper tract urothelial carcinoma (UTUC) undergoing surgery. Materials and Methods: We retrospectively reviewed the medical records of patients who were diagnosed with UTUC from October 2003 to December 2016 at Korea University Medical Center. Sterile pyuria was defined as urine containing five or more white blood cells per high-power field in the absence of bacteria in urine culture. We used a stepwise multivariable Cox proportional hazards model to assess the independent effects of the prognostic factors for IVR and OS. Results: We investigated a total of 176 patients who were diagnosed with UTUC. Among them, 91 (51.7%) patients had preoperative sterile pyuria. There were no significant differences in the baseline characteristics between the pyuria and non-pyuria groups concerning tumor grade, T stage, tumor multiplicity, and recurrence history. However, there was a significant difference in the IVR between the two groups. In the multivariable analysis, preoperative sterile pyuria, diabetes mellitus, high-grade tumor, and lymphovascular invasion were revealed as independent risk factors for IVR, and only lymphovascular invasion was identified as an independent risk factor for OS. Conclusions: Preoperative sterile pyuria is significantly associated with IVR in patients with UTUC undergoing surgery, but it is not associated with OS. Furthermore, diabetes mellitus, high-grade tumor, and lymphovascular invasion are also independent prognostic factors for these patients.

show abstract

“…Pyuria is a well-documented prognostic factor in urinary tract carcinomas, according to several research. [10][11][12][13][14] The relationship between preoperative pyuria and recurrence in patients with NMIBC is unclear, even though these studies found that pyuria was a strong predictor of poor prognosis in patients with NMIBC. Our study's objective was to compare the prognostic effect of pyuria and pre-treatment NLR on the likelihood of progression and recurrence in individuals with primary NMIBC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of preoperative pyuria & neutrophil to lymphocyte ratio in patients with non-muscle-invasive bladder cancer: A prospective cohort study

Singh,

Sharma,

Priyadarshi

et al. 2023

Urologia

View full text Add to dashboard Cite

Background: The most prevalent cancer of the urinary system and the fourth most frequent cancer in men is bladder cancer. Up to 45% of non-muscle-invasive bladder cancers (NMIBC), may develop into muscle-invasive disease within 5 years after initial diagnosis, depending on the risk profile. The neutrophil to lymphocyte ratio (NLR), which is an emerging marker of host inflammation and can be easily calculated from routine complete blood counts (CBCs) with differentials, has shown to be an independent prognostic factor for a variety of solid malignancies, including urinary tract cancer. Pyuria is a well-documented prognostic factor in urinary tract carcinomas, according to several research. The relationship between preoperative pyuria and recurrence in patients with NMIBC is unclear, even though some studies found that pyuria was a strong predictor of poor prognosis in patients with NMIBC. Our study’s objective was to compare the prognostic effect of pre-treatment pyuria and NLR on the likelihood of progression and recurrence in individuals with primary NMIBC. Materials and methodology: Data obtained from 100 bladder cancer patients who underwent transurethral resection of bladder tumor (TURBT) from June 2021 to January 2023 were evaluated prospectively. Inclusion criteria: Age more than 18 years, having tumor size less than 3 × 3 cm, single tumor, no H/O TURBT. Exclusion criteria: Age less than 18 years, size more than 3 × 3 cm, multiple tumors, H/O TURBT. Results: We demonstrated in the current study that, compared to NLR, preoperative pyuria was more substantially linked with intravesical recurrence, higher T stage and disease progression following TURBT for NMIBC.

show abstract

Preoperative pyuria predicts advanced pathologic tumor stage and worse survival in patients with urothelial carcinoma of the upper urinary tract treated by radical nephroureterectomy

Cited by 9 publications

References 30 publications

Effect of Preoperative Bacteriuria and Pyuria on Intravesical Recurrence in Patients with Upper Tract Urothelial Carcinoma Undergoing Radical Nephroureterectomy

Effect of Preoperative Bacteriuria and Pyuria on Intravesical Recurrence in Patients with Upper Tract Urothelial Carcinoma Undergoing Radical Nephroureterectomy

Preoperative sterile pyuria as a prognosticbiomarker for intravesical recurrence in upperurinary tract urothelial carcinoma

Prognostic significance of preoperative pyuria & neutrophil to lymphocyte ratio in patients with non-muscle-invasive bladder cancer: A prospective cohort study

Contact Info

Product

Resources

About