Preoperative Prognostic Value of Dynamic Contrast-Enhanced MRI-Derived Contrast Transfer Coefficient and Plasma Volume in Patients with Cerebral Gliomas

Abstract

BACKGROUND AND PURPOSE:The prognostic value of dynamic contrast-enhanced MR imaging-derived plasma volume obtained in tumor and the contrast transfer coefficient has not been well-established in patients with gliomas. We determined whether plasma volume and contrast transfer coefficient in tumor correlated with survival in patients with gliomas in addition to other factors such as age, type of surgery, preoperative Karnofsky score, contrast enhancement, and histopathologic grade.

Correlation of Tumor Immunohistochemistry with Dynamic Contrast-Enhanced and DSC-MRI Parameters in Patients with Gliomas

“…[1][2][3][4][5] Maps of blood volume or vascular permeability can also be generated across the whole tumor, allowing the neurosurgeon to determine preoperatively the most appropriate target for biopsy and/or resection. Validation of MR imaging-derived blood volume with microvessel area and density from immunohistochemistry is important because absolute CBV measurement is more difficult with MR imaging compared with CT.…”

“…Multiple acquisition and postprocessing techniques can influence DCE-and DSC-derived tumor blood volume measurements. 5,6,13 For DSC-MR imaging, gradient-echo sequences are sensitive to vessels of all sizes, whereas spin-echo sequences are mainly sensitive to capillaries. Gradient-echo DSC-MR imaging can have large-vessel contamination.…”

“…[1][2][3][4][5] Measurements of blood volume can be obtained by using dynamic contrast-enhanced (DCE) MR imaging or dynamic susceptibility contrast MR imaging. Both techniques have their own advantages and disadvantages.…”

The assessment of immature microvascular density in brain gliomas with dynamic contrast-enhanced magnetic resonance imaging

“…The degree of microvascular proliferation is different based on different grades of glioma. In high-grade glioma (HGG), these new microvessels are usually immature and their permeability is increased [1,2]. CD105 is specifically expressed in new and immature tumor microvessels [3][4][5].…”

Prognostic value of preoperative dynamic contrast-enhanced MRI perfusion parameters for high-grade glioma patients

“…Thus far, research on the prognostic value of DCE perfusion for HGG patient survival has been scarce—only a few studies have been conducted [10, 20, 24–26], some of them presenting contradicting results [27], focusing mostly on K trans and v p , and some of them employing the hot-spot method, where only tumor regions with subjectively highest parameter values are analyzed. We set out to partially fill this knowledge gap with a larger study sample and a comprehensive whole tumor volume histogram analysis of more DCE-MRI pharmacokinetic modeling parameters.…”