Preoperative predictors of the need for allogeneic blood transfusion in lung cancer surgery

Abstract

A predictive model can preoperatively identify patients at risk for needing ABT in lung cancer surgery. The model could be utilized to tailor blood-sparing intervention programs.

Impact of blood transfusions on outcome after pneumonectomy for thoracic malignancies

“…The need for blood transfusion within 30 days following surgery has been reported as ranging from 16-25% of all patients receiving lung cancer resection [1][2][3][4] and exceeded 40% in the present study, which focused on pneumonectomy, although a rather restrictive and homogeneous transfusion strategy was used over the study period. The transfused patients of the present study required large amounts of blood products, suggesting that they would not have been able to avoid such a treatment.…”

“…here have been very few clinical trials evaluating the blood-product needs in patients subjected to major thoracic oncological surgical procedures [1][2][3][4]. The issue is of clinical relevance since outcome data on transfusion therapy have not always been favourable, particularly in the areas of post-operative infection, systemic inflammatory response syndrome, multiple organ failure and finally mortality.…”

Predictors of transfusion for spinal surgery in Maryland, 1997 to 2000

“…In this study, we identified that advanced age, female sex, diabetes with chronic complications, and metastatic tumor were consistently predictive of transfusion during spinal surgery, including any allogeneic transfusion and RBC transfusion. Previous data regarding associations between patient characteristics and outcomes in high‐risk surgical patients have been derived primarily from clinical trials, chart review, or administrative databases from a single institution 7‐14 . In such studies of patients undergoing orthopedic surgery, patient factors that have been identified to be associated with increased blood transfusion include baseline Hb, 7,8,11,13 autologous donation status, 8,13 patient weight, 8 patient blood volume, 11 presence of tumor, 13 pulmonary disease, 13 type of surgery, 8,13 and primary versus revision surgery 8 …”

“…[3][4][5][6] Previous data regarding associations between patient characteristics and outcomes in high-risk surgical patients have been derived primarily from clinical trials 7 and may not reflect patient risk characteristics in the general population. Other studies have used administrative databases or chart review [8][9][10][11][12][13][14] to evaluate the association between patient characteristics and transfusion at a single institution. By using a statewide administrative database, we conducted a population-based study to evaluate the factors that predict transfusion for a large number of patients undergoing spinal surgery at multiple hospitals.…”

Association of Allogeneic Red-Blood Cell Transfusion with Surgeon Case-Volume

“…Patient factors drive the decision for some RBC transfusions [14][15][16][17][18][19]; however, non-patient level factors may also be important. Specifically, studies suggest that surgeon casevolume is associated with incidence of transfusion among patients undergoing spine [20], colorectal [21], and cardiac surgery [22].…”