Preoperative Predictive Factors for Gastrointestinal Stromal Tumors: Analysis of 375 Surgically Resected Gastric Subepithelial Tumors

Ye, Min; Park, Ha Na; Min, Byung–Hoon; Choi, Dongil; Kim, Kyoung‐Mee; Kim, Sung

doi:10.1007/s11605-014-2708-9

Cited by 30 publications

(41 citation statements)

References 24 publications

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“…The amount of cytological material obtained by EUS‐FNA is often insufficient for the immunohistochemical staining required to differentially diagnose SET. Because of this limitation, the diagnostic yield of EUS‐FNA for gastric SET is limited, ranging from 34% to 79% …”

Section: Introductionmentioning

confidence: 99%

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Randomized crossover trial comparing EUS‐guided fine‐needle aspiration with EUS‐guided fine‐needle biopsy for gastric subepithelial tumors

Iwai

Kida

Inoue

et al. 2017

Diagnostic Cytopathology

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Section: Introductionmentioning

confidence: 99%

“…Because of this limitation, the diagnostic yield of EUS-FNA for gastric SET is limited, ranging from 34% to 79%. [2][3][4] To overcome these limitations associated with the aspiration needle, a new biopsy needle with reverse-bevel technology (ProCore;…”

Section: Introductionmentioning

confidence: 99%

Randomized crossover trial comparing EUS‐guided fine‐needle aspiration with EUS‐guided fine‐needle biopsy for gastric subepithelial tumors

Iwai

Kida

Inoue

et al. 2017

Diagnostic Cytopathology

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show abstract

“…Gastric SETs encompass a diverse array of benign, potentially malignant, and malignant lesions [3,4]. Endoscopic ultrasonography (EUS) is recommended to narrow the differential diagnosis of SETs as it can help ascertain key pathologic characteristics such as depth, size, and the layer of origin within the gastrointestinal wall.…”

mentioning

confidence: 99%

Diagnostic yield of endoscopic ultrasonography-guided single-incision needle knife biopsy for gastric subepithelial tumors: comparison with resected specimens

Kim

et al. 2016

Surg Endosc

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“…Patients of an older age, tumor site location outside the gastric cardia, large tumor size, exophytic growth pattern, and ulceration or dimpling are independent preoperative predictive factors for GISTs versus non-GISTs [16]. …”

Section: Discussionmentioning

confidence: 99%

Subepithelial rectal gastrointestinal stromal tumor – the use of endoscopic ultrasound-guided fine needle aspiration to establish a definitive cytological diagnosis: a case report

et al. 2017

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BackgroundGastrointestinal stromal tumors are the most common mesenchymal neoplasms affecting the gastrointestinal tract. The stomach is the most common location to be affected, and the rectum one of the rarest, but the whole gastrointestinal tract remains susceptible. Gastrointestinal stromal tumors account for only 0.1% of rectal tumors. Currently, endoscopic ultrasound plays an essential role in the diagnostic process of gastrointestinal stromal tumors, especially when the affected sites have a worse outcome and higher morbidity rates.Case presentationWe describe the case of a 68-year-old white Japanese man with a history of long-term mild rectal pain and tenesmus. A digital rectal examination revealed a right palpable solid mass ranging from 3 to 7 cm from his anal verge. A colonoscopy was performed and showed a 5 cm elevated lesion covered by normal mucosa, located 4 cm above the pectineal line. Endoscopic ultrasound confirmed the diagnosis of a homogeneous hypoechoic mass with areas of necrosis as a rectal subepithelial lesion originating at the fourth layer (muscularis propria). He then underwent endoscopic ultrasound-guided fine needle aspiration of the lesion, followed by cytological and immunohistochemistry evaluation. The evaluation showed spindle and epithelioid cells of variable sizes, in fascicles separated by stroma, which reacted firmly and consistently to CD117/c-kit and CD34, and negative to desmin and S-100 protein. There was weak staining for nuclear Ki-67 in the tumor cells. A diagnosis of rectal gastrointestinal stromal tumor was confirmed. After a multidisciplinary meeting, an abdominoperineal resection of his rectum was performed. The pathology of the specimen confirmed the diagnosis of rectal gastrointestinal stromal tumor. He is now asymptomatic after 3 months’ follow-up and is on adjuvant therapy with a tyrosine-kinase inhibitor.ConclusionsGastrointestinal stromal tumors are rare tumors, and among the variety of primary location sites, the rectum is one of the rarest. The localization of this type of tumor has worse outcomes and higher morbidity rates. We report this rare case to emphasize the need for precise diagnosis and the important role of endoscopic ultrasound-guided fine needle aspiration in such situations.

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Preoperative Predictive Factors for Gastrointestinal Stromal Tumors: Analysis of 375 Surgically Resected Gastric Subepithelial Tumors

Abstract: The effort for preoperative pathologic diagnosis such as endosonography-guided tissue sampling might be positively considered for SETs at cardia and SETs with PLNE where the possibility of GIST is low.

Cited by 30 publications

References 24 publications

Randomized crossover trial comparing EUS‐guided fine‐needle aspiration with EUS‐guided fine‐needle biopsy for gastric subepithelial tumors

Randomized crossover trial comparing EUS‐guided fine‐needle aspiration with EUS‐guided fine‐needle biopsy for gastric subepithelial tumors

Diagnostic yield of endoscopic ultrasonography-guided single-incision needle knife biopsy for gastric subepithelial tumors: comparison with resected specimens

Subepithelial rectal gastrointestinal stromal tumor – the use of endoscopic ultrasound-guided fine needle aspiration to establish a definitive cytological diagnosis: a case report

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