Preoperative Pneumonia and Postoperative Venous Thrombosis: A Cohort Study of 427,656 Patients Undergoing Major General Surgery

Abstract

A large, multicenter database of surgical patients showed that preoperative pneumonia may increase risk for developing venous thrombosis. This adds to our understanding of risk factors for venous thrombosis and suggests a potential benefit of diagnosing preoperative pneumonia in patients undergoing major general surgery.

Prognostic Implications of Preoperative Pneumonia for Geriatric Patients Undergoing Hip Fracture Surgery or Arthroplasty

“…Generally, the type of surgery performed was decided according to the protocols of our institution, summarized as follows: 18 and activities of daily living [ADL] score) 19 ; (iii) laboratory test results (e.g. for white blood cell count and C-reactive protein); and (iv) comorbidities and other histories.…”

“…Sarah et al reported an increase in the postoperative mortality rate in patients undergoing orthopaedic, thoracic, and vascular surgeries with preoperative pneumonia 18 . In a large multicenter retrospective cohort study that included 427,656 patients admitted for major general surgeries, preoperative pneumonia was identified as a risk factor of venous thrombosis after surgery 19 . Although preoperative pneumonia was related to poor prognosis after surgery, many patients were still undergoing surgeries when antibiotic therapy was initiated; this may be influenced by the timing of the specific surgery 18,19 .…”

“…In a large multicenter retrospective cohort study that included 427,656 patients admitted for major general surgeries, preoperative pneumonia was identified as a risk factor of venous thrombosis after surgery 19 . Although preoperative pneumonia was related to poor prognosis after surgery, many patients were still undergoing surgeries when antibiotic therapy was initiated; this may be influenced by the timing of the specific surgery 18,19 . However, unlike postoperative pneumonia, preoperative pneumonia has rarely been a focus in hip fracture studies.…”

Factors Predictive of Postoperative Acute Respiratory Failure Following Inpatient Sinus Surgery

“…Perioperative pneumonia is associated with postoperative complications following a broad range of surgeries. 13,14 Here, we showed that pneumonia was associated with a 6-fold increase in postoperative acute respiratory failure following sinus surgery. Preoperative optimization and treatment of pneumonia should continue and elective surgery be delayed until pneumonia resolves.…”

Hospitalization With Infection and Incident Venous Thromboembolism: The ARIC Study

“…First, the prevalence of hospitalization with infection 14, 30, 42, and 90-days prior to VTE was compared to the corresponding time periods exactly 1 and 2 years prior to the VTE event. Conditional logistic regression was used to estimate odds ratios (OR) of VTE and 95% confidence intervals (CIs) for each time period (14,30,42, and 90 days). We controlled for the number of hospitalizations in the 9 months preceding each case or control period to account for potential decline in overall health status due to age and immobility associated with hospitalization.…”