Preoperative plateletcrit is a Prognostic Biomarker for Survival in Patients with Non-Small Cell Lung Cancer

Abstract

Objectives: Several factors associated with the prognosis of patients with NSCLC have been reported in the literature; however, most of these factors cannot be examined preoperatively. In this study, the clinical utility of platelet parameters in patients with NSCLC who underwent curative resection was evaluated. Materials and Methods: A retrospective study on patients with NSCLC who underwent curative resection from July 2006 to September 2016 was conducted. The Cox proportional hazard regression model was applied to evaluate the variables that demonstrated effects on disease-free and overall survival (DFS and OS). Results: A total of 116 patients with NSCLC were analyzed. There were 15 patients with plateletcrit greater than 0.2755%, and 101 patients whose plateletcrit was 0.2755% or lower. Multivariate analysis identified plateletcrit higher than 0.2755% (hazard ratio [HR] = 4.18, 95% confidence interval [CI] = 1.54-11.34, P =0.004), patient age of 65 years or more (HR = 4.02, 95% CI = 1.67−9.66, P = 0.001), and stage II or IIIA disease (HR = 2.95, 95% CI = 1.26−6.87, P = 0.012) as independent factors for OS that predicted a poor prognosis. Multivariate analysis identified plateletcrit higher than 0.2755% (HR = 4.07, 95% CI = 1.52−10.94, P = 0.005), stage II or IIIA disease (HR = 5.38, 95% CI = 2.71−10.66, P < 0.001) and non-adenocarcinoma (HR = 1.92, 95% CI = 1.02-3.59, P = 0.040) as independent prognostic factors for DFS that predicted a poor prognosis. Conclusion: Our results suggest a potential role of preoperative plateletcrit as an independent prognostic marker for patients with resectable NSCLC.

Preoperative blood testing for glioblastoma, brain metastases, and primary central nervous system lymphoma differentiation

“…Higher PCT levels were found in papillary thyroid carcinoma patients than in healthy controls and multinodular goiters ( 20 ). In addition, high PCT levels have been associated with a poor prognosis of pancreatic adenocarcinoma and non-small cell lung cancer ( 21 , 22 ). However, studies focusing on the diagnostic significance of PCT are limited.…”

Evaluation of preoperative blood test as a useful tool to differentiate glioblastoma, brain metastases and primary central nervous system lymphoma

“…It was reported that the PCT was higher in papillary thyroid carcinoma group than health control and multinodular goiter [22]. In addition, high PCT has been demonstrated to have a relation with a poor prognosis of pancreatic adenocarcinoma and non-small cell lung cancers (NSCLCs) [23,24]. However, studies focused on the diagnostic signi cance of PCT were limited.…”

Prognostic significance of mean platelet volume in patients with lung cancer: a meta-analysis

“…Finally, 11 full-text articles including 2421 patients with lung cancer were included. 11,15,[22][23][24][25][26][27][28][29][30] Meanwhile, the meta-analysis only included studies of patients with NSCLC (n ¼ 9). The characteristics of the included studies are presented in Table 1.…”

“…Five studies were conducted in China, 8,[24][25][26]29 three studies were conducted in Turkey, 15,22,23 two studies were conducted in Japan, 11,30 and one study was conducted in Korea. 28 A study by Shi et al had two datasets for HRs for patients with adenocarcinoma and squamous cell carcinoma. 24 Similarly, survival outcomes were described for patients with NSCLC in nine studies, patients with small cell lung cancer (SCLC) in one study, and patients with either NSCLC or SCLC in one study.…”

“…Nine studies 11,15,[22][23][24][25][26][27][28]30 including 2182 patients were included in the meta-analysis to assess the association between MPV and OS (Figures 2 and 3). The pooled HR for OS was 1.09 (95% CI ¼ 0.84-1.41, P ¼ 0.53).…”