Preoperative platelet lymphocyte ratio is superior to neutrophil lymphocyte ratio to be used as predictive marker for lymph node metastasis in oral squamous cell carcinoma

Acharya, Swetha; Rai, Pragati; Hallikeri, Kaverı; Anehosur, Venkatesh; Kale, Jyoti

doi:10.1111/jicd.12219

Cited by 33 publications

(26 citation statements)

References 21 publications

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“…Preoperative PLR is superior to NLR for predicting lymph node metastases in OSCC. 27 Similar to NLR and PLR, our results also showed that RDW could reflect enhanced inflammation, metastasis, and advanced stage in OSCC patients.…”

Section: Discussionsupporting

confidence: 72%

Elevated red blood cell distribution width predicts poor prognosis in patients with oral squamous cell carcinoma

Xie

Chang

2018

CMAR

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IntroductionAlthough red blood cell distribution width (RDW) has been reported to reflect inflammation and nutritional status and to predict prognosis in several different types of cancer, little is known about how RDW might be related to oral squamous cell carcinoma (OSCC). The present study aimed to investigate the prognostic value of preoperative RDW in OSCC patients.Materials and methodsWe included 236 OSCC patients from Jinan Stomatological Hospital (Shandong, People’s Republic of China) in this retrospective study. All enrolled patients were divided into 2 groups: high RDW (≥15%) and low RDW (<15%) according to the detected RDW values. The correlation of RDW and clinical characteristics was explored, and the prognostic significance of RDW evaluated using Kaplan–Meier curves, log-rank analysis, and the Cox proportional hazards model.ResultsThe pretreatment median RDW among all OSCC patients was 14.4%, with a range from 11.6% to 24.5%. The RDW was found to be significantly correlated with node metastasis, tumor length, and TNM stage (P<0.05 for all). As for biochemical parameters, the results showed that higher RDW values were significantly associated with hemoglobin, mean corpuscular volume, white blood cell count, albumin, and C-reactive protein (P<0.01 for all). A significant association of RDW with the tumor marker cytokeratin 19 fragments (CYFRA21-1) and squamous cell carcinoma antigen (SCC-Ag) was also observed (P=0.02, and P=0.03; respectively). Moreover, patients with higher RDW were more likely to receive postoperative therapy (P=0.02). Kaplan–Meier survival curves showed that a high RDW was significantly associated with poor overall survival (OS) (P<0.01), especially in the early stages (I–II). Multivariate analysis revealed that an elevated RDW at diagnosis was an independent prognostic factor for shorter OS (HR =1.46, 95% CI: 1.13–2.86) after adjustment for other cancer-related prognostic factors.ConclusionThese data suggest that an elevated preoperative RDW (≥15%) at diagnosis may independently predict poorer OS in patients with OSCC, but better-designed studies in the future should be performed to further confirm the value of monitoring RDW.

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Section: Discussionsupporting

confidence: 72%

Elevated red blood cell distribution width predicts poor prognosis in patients with oral squamous cell carcinoma

Xie

Chang

2018

CMAR

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“…All studies were retrospective. Twelve studies were conducted in Asia [11,13,14,16,21–28] and two were performed in Europe [12,15]. The cut-off values for the NLR ranged from 1.77 to 5.…”

Section: Resultsmentioning

confidence: 99%

“…The NLR has been reported to be a significant prognostic marker for a number of malignancies, including colorectal cancer [6], bladder cancer [7], breast cancer [8], ovarian cancer [9], and non-small-cell lung cancer [10]. Recently, many studies have also explored the prognostic and clinical significance of the NLR in oral cancer; however, the results have been inconclusive [11–16]. Therefore, to further verify the prognostic role of the NLR in oral cancer, we conducted a meta-analysis by pooling data from relevant studies.…”

Section: Introductionmentioning

confidence: 99%

Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer

et al. 2018

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Objectives: Many studies have examined the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in oral cancer; however, the results are contradictory. We, therefore, conducted a meta-analysis aiming to clarify the prognostic value of the NLR in oral cancer patients. Methods: A literature search was conducted in the PubMed, Web of Science, and Embase databases. Stata version 12.0 was used for statistical analysis. Results: A total of 14 studies with 3216 patients were finally included. The results indicated that a high NLR was significantly associated with worse DFS (n=10, HR = 1.73, 95% confidence interval [CI] = 1.44–2.07, P<0.001). Similar results were observed for overall survival (OS) (n=9, HR = 1.61, 95% CI = 1.39–1.86, P<0.001). Moreover, a high NLR was also correlated with lymph node metastasis (n=7, odds ratio [OR] = 1.62, 95% CI = 1.32–1.98, P<0.001), advanced tumor stage (n=7, OR = 2.63, 95% CI = 2.12–3.25, P<0.001), T stage (n=6, OR = 3.22, 95% CI = 2.59–4.01, P<0.001), tumor differentiation (n=5, OR = 1.48, 95% CI = 1.03–2.11, P=0.033), and perineural invasion (n=4, OR = 1.83, 95% CI = 1.4–2.39, P<0.001). However, an elevated NLR was not correlated with gender. Conclusion: This meta-analysis showed that the NLR might be a potential independent prognostic factor in patients with oral cancer.

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“…The PRISMA flow chart of the systematic review can be found in Figure . An initial search done using the search strategy (Supporting Materials) obtained an initial 900 results.…”

Section: Methodsmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta‐analysis

et al. 2018

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Preoperative platelet lymphocyte ratio is superior to neutrophil lymphocyte ratio to be used as predictive marker for lymph node metastasis in oral squamous cell carcinoma

Abstract: Preoperative PLR is directly associated with nodal involvement status of OSCC. Preoperative PLR is superior to NLR for predicting LNM in OSCC.

Cited by 33 publications

References 21 publications

Elevated red blood cell distribution width predicts poor prognosis in patients with oral squamous cell carcinoma

Elevated red blood cell distribution width predicts poor prognosis in patients with oral squamous cell carcinoma

Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer

Neutrophil‐to‐lymphocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta‐analysis

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