Preoperative percutaneous needle lung biopsy techniques and ipsilateral pleural recurrence in stage I lung cancer

Kim, Min Gwan; Yang, Bo; Park, Chang Min; Yoon, Soon Ho

doi:10.1007/s00330-021-08359-x

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…Current data [ 14 ] [ 15 ] and our case report indicate that late diagnostic complications may become more frequent in the future. In Germany, CT-guided lung biopsy has almost doubled from 2005 to 2021, while bronchoscopic tumor sampling declined probably by the Covid-19 pandemic (Fig.…”

Section: Discussionmentioning

confidence: 73%

“…While past data and did not show a relevant effect of needle tract seeding and following metastasis by percutaneous biopsy [ 12 ] [ 13 ], there is currently increasing evidence for a significant effect, especially in stage-I-tumors [ 15 ] [ 14 ]. It might be assumed that this could be driven by therapeutic advances leading to a longer overall survival and revealing overlooked consequences.…”

Section: Discussionmentioning

confidence: 99%

“…[ 13 ] Nevertheless, two recently published studies suggested an increase in the prevalence of tumor seeding following CT-guided biopsy. Gwan Kim et al reported pleural recurrence in 40 of 415 cases (9,6%) [ 14 ], Hong et al in 118 of 1158 cases (10,2%) [ 15 ] with stage I lung cancer.…”

Section: Introductionmentioning

confidence: 99%

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Tumor seeding following CT- guided transthoracic needle biopsy in lung cancer. A case report

Melzer,

Hackl,

Walter

et al. 2023

BMC Pulm Med

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As a result of advances in the treatment of lung cancer, the life expectancy of lung cancer patients has improved significantly, but it remains the leading cause of cancer death worldwide. For decades, most of the initial tumor biopsies have been obtained by bronchoscopy or computed tomography (CT)-guided transthoracic lung biopsy without concerning reports of cancer seeding following the latter. In this case report we discuss the patient history of a 56-year old women with low-differentiated squamous cell lung cancer who developed tumor seeding following a CT-guided transthoracic biopsy 11 months after the intervention. This is put into context reviewing former and current literature.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Tumor seeding following CT- guided transthoracic needle biopsy in lung cancer. A case report

Melzer,

Hackl,

Walter

et al. 2023

BMC Pulm Med

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“…The effect of PTNB on pleural metastases has been evaluated in several studies, but the conclusion is still controversial. Other individual retrospective studies have shown that PTNB was not associated with pleural recurrence [ 24 , 28 ], and PTNB techniques [ 6 ] were not significantly associated with the risk of pleural recurrence and survival [ 30 ]. However, some studies have come to the opposite conclusion [ 4 , 21 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Multiple studies have shown that PTNB increases the risk of pleural recurrence after surgery in lung cancer [ 4 , 5 ], but this view has been opposed by other studies [ 6 ]. The conclusion is still controversial.…”

Section: Introductionmentioning

confidence: 99%

Effects of pre-operative biopsy on recurrence and survival in stage I lung adenocarcinoma patients in China

Zhang

et al. 2023

ERJ Open Res

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BackgroundWhether preoperative biopsy affects postoperative recurrence and metastasis of lung cancer patients is still controversial.MethodsIn order to clarify the disputes mentioned above, we collected relevant literatures to conduct a meta-analysis. Furthermore, to validate the results of the meta-analysis, we retrospectively analysed 575 patients with stage I lung adenocarcinoma who underwent surgical resection in our center from 2010 to 2018 using propensity score matching and competing risk models.Results5509 lung cancer patients from 11 articles were included in the meta-analysis. Summary analysis showed the total recurrence rate of biopsy group was higher than that of non-biopsy group (Risk radio (RR)=1.690 (1.220, 2.330), p=0.001). After propensity score matching, we found that there was no significant correlation between biopsy and total recurrence (RR=1.070 (0.540, 2.120), p=0.850). In our cohort, of 575 stage I lung adenocarcinomas, 113 (19.7%) patients underwent preoperative biopsy. During a median follow-up of 71 (57, 93) months, multivariable analyses showed preoperative biopsy in the overall observation cohort [sub-distribution hazard ratio (SHR)=1.522; 95% confidence interval (CI): 0.997–2.320; p=0.051] and in the propensity score-matched cohort (SHR=1.134; 95% CI: 0.709–1.810; p=0.600) was not significantly correlated with the risk of recurrence and metastasis. What's more, preoperative biopsy didn't affect disease-free survival (SHR=0.853, 95%CI: 0.572–1.273; p=0.438) and overall survival (SHR=0.647, 95%CI: 0.352–1.189; p=0.161).ConclusionPreoperative biopsy might not increase the risk of recurrence and metastasis, suggesting these procedures might be safe for patients with stage I lung adenocarcinoma whose diagnosis is difficult to determine before surgery.

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Effect of smoking on the diagnostic results and complication rates of percutaneous transthoracic needle biopsy

Lim,

Lee,

Park

et al. 2024

Eur Radiol

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Objective To investigate the association of smoking with the outcomes of percutaneous transthoracic needle biopsy (PTNB). Methods In total, 4668 PTNBs for pulmonary lesions were retrospectively identified. The associations of smoking status (never, former, current smokers) and smoking intensity (≤ 20, 21–40, > 40 pack-years) with diagnostic results (malignancy, non-diagnostic pathologies, and false-negative results in non-diagnostic pathologies) and complications (pneumothorax and hemoptysis) were assessed using multivariable logistic regression analysis. Results Among the 4668 PTNBs (median age of the patients, 66 years [interquartile range, 58–74]; 2715 men), malignancies, non-diagnostic pathologies, and specific benign pathologies were identified in 3054 (65.4%), 1282 (27.5%), and 332 PTNBs (7.1%), respectively. False-negative results for malignancy occurred in 20.5% (236/1153) of non-diagnostic pathologies with decidable reference standards. Current smoking was associated with malignancy (adjusted odds ratio [OR], 1.31; 95% confidence interval [CI]: 1.02–1.69; p = 0.03) and false-negative results (OR, 2.64; 95% CI: 1.32–5.28; p = 0.006), while heavy smoking (> 40 pack-years) was associated with non-diagnostic pathologies (OR, 1.69; 95% CI: 1.19–2.40; p = 0.003) and false-negative results (OR, 2.12; 95% CI: 1.17–3.92; p = 0.02). Pneumothorax and hemoptysis occurred in 21.8% (1018/4668) and 10.6% (495/4668) of PTNBs, respectively. Heavy smoking was associated with pneumothorax (OR, 1.33; 95% CI: 1.01–1.74; p = 0.04), while heavy smoking (OR, 0.64; 95% CI: 0.40–0.99; p = 0.048) and current smoking (OR, 0.64; 95% CI: 0.42–0.96; p = 0.04) were inversely associated with hemoptysis. Conclusion Smoking history was associated with the outcomes of PTNBs. Current and heavy smoking increased false-negative results and changed the complication rates of PTNBs. Clinical relevance statement Smoking status and intensity were independently associated with the outcomes of PTNBs. Non-diagnostic pathologies should be interpreted cautiously in current or heavy smokers. A patient’s smoking history should be ascertained before PTNB to predict and manage complications. Key Points • Smoking status and intensity might independently contribute to the diagnostic results and complications of PTNBs. • Current and heavy smoking (> 40 pack-years) were independently associated with the outcomes of PTNBs. • Operators need to recognize the association between smoking history and the outcomes of PTNBs.

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Preoperative percutaneous needle lung biopsy techniques and ipsilateral pleural recurrence in stage I lung cancer

Cited by 5 publications

References 16 publications

Tumor seeding following CT- guided transthoracic needle biopsy in lung cancer. A case report

Tumor seeding following CT- guided transthoracic needle biopsy in lung cancer. A case report

Effects of pre-operative biopsy on recurrence and survival in stage I lung adenocarcinoma patients in China

Effect of smoking on the diagnostic results and complication rates of percutaneous transthoracic needle biopsy

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