Preoperative NT-proBNP independently predicts outcome in patients with acute coronary syndrome undergoing CABG*

Holm, Jonas; Vidlund, Mårten; Vánky, Farkas; Friberg, Örjan; Håkanson, Erik; Svedjeholm, Rolf

doi:10.3109/14017431.2012.731518

Cited by 19 publications

(25 citation statements)

References 17 publications

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“…The mechanism involved in NT-proBNP release in ischemia is not entirely clear 120 , although Xu et al observed a relationship between NT-proBNP and CAD severity 121 . The results of our study supported previous findings that showed that, in cardiac surgery, NT-proBNP levels were associated with morbidity and mortality [122][123][124][125][126] . In contrast to other studies, we found that the ability of NT-proBNP to predict severe PHF was less convincing in the context of AS 108 .…”

Section: Nt-probnp and Phfsupporting

confidence: 92%

Implications of myocardial dysfunction before and after aortic valve intervention

Hultkvist

2019

Linköping University Medical Dissertations

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Section: Nt-probnp and Phfsupporting

confidence: 92%

Implications of myocardial dysfunction before and after aortic valve intervention

Hultkvist

2019

Linköping University Medical Dissertations

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“…SubP gave higher specificity (83%) and sensitivity (80%) than NT-proBNP which was reported as an early marker candidate for the diagnosis of AMI patients in many groups. 10,21,27 From above results, we suggested SubP and NPY as early diagnostic biomarkers for AMI patients. The combination of two peptides analysis will give a chance to find for AMI patients in early stage.…”

Section: Resultsmentioning

confidence: 99%

“…21,25 Unfortunately, the area under the receiver operating characteristic (ROC) curve was below 70% and sensitivity and specificity values were below 80%. 26,27 Therefore, the development of a more sensitive and specific diagnostic biomarker is necessary for the early diagnosis of AMI.…”

Section: Introductionmentioning

confidence: 99%

Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients

Han¹,

Seo²,

Jung³

et al. 2014

Bulletin of the Korean Chemical Society

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Substance P and neuropeptide Y were discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients' sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients' sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI.

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“…Preoperative levels of its sister compound, brain natriuretic peptide (BNP), have been used to predict postoperative mortality in patients undergoing cardiac surgery procedures, including CABG 41, 42. Additionally, studies on patients undergoing isolated CABG found associations between preoperative levels of NT‐ProBNP and postoperative mortality, prompting inclusion of preoperative levels of the biomarker into our models 16, 43, 44…”

Section: Discussionmentioning

confidence: 99%

Predictive Ability of Novel Cardiac Biomarkers ST2, Galectin‐3, and NT‐ProBNP Before Cardiac Surgery

Polineni

Parker

Alam

et al. 2018

JAHA

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BackgroundCurrent preoperative models use clinical risk factors alone in estimating risk of in‐hospital mortality following cardiac surgery. However, novel biomarkers now exist to potentially improve preoperative prediction models. An assessment of Galectin‐3, N‐terminal pro b‐type natriuretic peptide (NT‐ProBNP), and soluble ST2 to improve the predictive ability of an existing prediction model of in‐hospital mortality may improve our capacity to risk‐stratify patients before surgery.Methods and ResultsWe measured preoperative biomarkers in the NNECDSG (Northern New England Cardiovascular Disease Study Group), a prospective cohort of 1554 patients undergoing coronary artery bypass graft surgery. Exposures of interest were preoperative levels of galectin‐3, NT‐ProBNP, and ST2. In‐hospital mortality and adverse events occurring after coronary artery bypass graft were the outcomes. After adjustment, NT‐ProBNP and ST2 showed a statistically significant association with both their median and third tercile categories with NT‐ProBNP odds ratios of 2.89 (95% confidence interval [CI]: 1.04–8.05) and 5.43 (95% CI: 1.21–24.44) and ST2 odds ratios of 3.96 (95% CI: 1.60–9.82) and 3.21 (95% CI: 1.17–8.80), respectively. The model receiver operating characteristic score of the base prediction model (0.80 [95% CI: 0.72–0.89]) varied significantly from the new multi‐marker model (0.85 [95% CI: 0.79–0.91]). Compared with the Northern New England (NNE) model alone, the full prediction model with biomarkers NT‐proBNP and ST2 shows significant improvement in model classification of in‐hospital mortality.ConclusionsThis study demonstrates a significant improvement of preoperative prediction of in‐hospital mortality in patients undergoing coronary artery bypass graft and suggests that biomarkers can be used to identify patients at higher risk.

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Preoperative NT-proBNP independently predicts outcome in patients with acute coronary syndrome undergoing CABG*

Abstract: Preoperative NT-proBNP predicted in-hospital mortality, severe circulatory failure postoperatively and long-term survival in patients undergoing surgery for acute coronary syndrome but a higher threshold was found in patients having concomitant procedures.

Cited by 19 publications

References 17 publications

Implications of myocardial dysfunction before and after aortic valve intervention

Implications of myocardial dysfunction before and after aortic valve intervention

Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients

Predictive Ability of Novel Cardiac Biomarkers ST2, Galectin‐3, and NT‐ProBNP Before Cardiac Surgery

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