Preoperative neutrophil-to-lymphocyte ratio predicts the surgical outcome of Xp11.2 translocation/TFE3 renal cell carcinoma patients

Agizamhan, Sezim; Qu, Feng; Gan, Weidong; Sun, Jing; Xu, Wei; Zhang, Lihua; Guo, Hongqian; Gan, Weidong

doi:10.1186/s12894-018-0374-z

Cited by 15 publications

(28 citation statements)

References 33 publications

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“…Possible risk factors for progression-free survival and overall survival were rstly scanned with chi-square tests (for categorical covariates) and t-tests (for continuous covariates) to compare patients who suffered from progression (or death) and who did not. NLR, PLR and CRP/Alb were transcoded into categorical variables with cutoff values set at 2.45, 140 and 0.083 respectively according to a prior study [6] . Variables with p < 0.10 revealed by univariate comparison were further analyzed with multivariate Cox regression.…”

Section: Discussionmentioning

confidence: 99%

“…Several attempts have been made to investigate the possible risk factors for survival [6,7] which suggest several possible risk factors as NLR, CRP/Alb, PLR and tumor thrombosis of IVC and tumor stage.…”

Section: Discussionmentioning

confidence: 99%

“…Preoperative neutrophil count, lymphocyte count, platelet count, hemoglobin level, C-reactive protein (CRP) level, albumin level, lactic dehydrogenase (LDH) level, brinogen (Fbg) level were collected. Possible prognostic factors as NLR (neutrophil-to-lymphocyte ratio), PLR (platelet-to-lymphocyte ratio), CRP/Alb (CRP/albumin ratio) [6] were calculated. Presence of tumor thrombus of inferior vena cava (IVC), lymph node metastasis and distant metastasis were con rmed from radiological examinations.…”

Section: Patientsmentioning

confidence: 99%

“…It has been classi ed as a distinct entity in the 2004 World Health Organization renal tumor classi cation and is now regarded as an important subtype of RCC, especially in children [4,5] . Compared to other subtypes of RCC, this neoplasm has more aggressive clinicopathologic features at diagnosis [5] and worse prognosis [3,6] . In regard to the risk of disease reoccurrence and death, it is important to conduct prognostic studies to identify potential preoperative risk factors for disease progression and death which might help to guide interventions in the future.…”

Section: Introductionmentioning

confidence: 99%

“…In regard to the risk of disease reoccurrence and death, it is important to conduct prognostic studies to identify potential preoperative risk factors for disease progression and death which might help to guide interventions in the future. Moreover, prognostic researches for adult patients, should be especially encouraged due to at least three reasons: rstly, as a rare disease which mainly affects children [4] , data for adult patients is scarce for the time being which awaits further illumination; secondly, this disease manifests with a more aggressive behavior in adults than in children [3] which suggests a possibly different prognostic features in adults; thirdly, prior prognostic studies, which revealed several possible risk factors as neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CRP/Alb ratio), platelet-to-lymphocyte ratio (PLR), tumor stage and inferior vena cava tumor thrombosis, included both child and adult patients [6,7] for analysis which might bring bias. Therefore, it would be of importance to identify novel prognostic factors in adult XP11.2 translocation RCC patients.…”

Section: Introductionmentioning

confidence: 99%

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Preoperative Plasma Fibrinogen: An Independent Predictor for Survival in Adult Patients with Xp11.2 Translocation Renal Cell Carcinoma

Dong¹,

Xu²,

Ji³

et al. 2020

Preprint

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Background. Xp11.2 translocation renal cell carcinoma, a rare malignancy, is more common in children than in adults. It manifests with an aggressive course in adults and relatively indolent in children. Prognostic studies for adult patients are scare for the rarity of the disease; and the prognostic value of preoperative plasma fibrinogen awaits further illumination.Methods. This retrospective single-center study enrolled 24 consecutive newly diagnosed Xp11.2 translocation RCC adult patients. Clinical presentations, baseline laboratory results and follow-up data were collected. Possible risk factors for progression free survival and overall survival were first scanned with chi-square tests and t-tests to compare patients who suffered from progression or death and who did not. Multivariate Cox regression was further utilized to identify independent risk factors.Results. Twenty-four adult patients (median age 32, range 16-73), with a male-to-female ratio of 1:1, was included from 2010.4 to 2020.3. After a mean follow-up of 35.7months, seven patients died. With univariate analysis, higher C-reactive protein-to-albumin ratio (p=0.028), higher baseline fibrinogen (p=0.006), and presence of distant metastasis (p=0.007) were associated with progression of disease; higher preoperative fibrinogen (p=0.014) and distant metastasis (p=0.020) were associated with death. With multivariate Cox regression, only baseline fibrinogen level (p=0.001) was identified as an independent risk factor for progression free survival; meanwhile, fibrinogen level (p=0.048) and distant metastasis (p=0.043) were identified as independent risk factors for survival.Conclusions. Preoperative plasma fibrinogen, a routinely tested parameter before surgery, is a promising tool for risk stratification in adult patients with Xp11.2 translocation renal cell carcinoma.JIE et al: Preoperative plasma fibrinogen predicts outcome in Xp11.2 translocation RCC

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preoperative Plasma Fibrinogen: An Independent Predictor for Survival in Adult Patients with Xp11.2 Translocation Renal Cell Carcinoma

Dong¹,

Xu²,

Ji³

et al. 2020

Preprint

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Xp11.2 Translocation Renal Cell Carcinoma: Clinical Characteristics and Potential Prognostic Predictors

Dong

et al. 2021

Disease Markers

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Background. Xp11.2 translocation renal cell carcinoma, a rare malignancy, has a higher prevalence in children than in adults. It is relatively indolent in children but manifests with an aggressive course in adults. Clinical characteristics and prognostic studies for adult patients are scarce due to its rarity. Methods. This retrospective single-center study consecutively enrolled 24 newly diagnosed Xp11.2 translocation RCC adult patients. Clinical presentations were recorded, and baseline laboratory results and follow-up data were collected. Possible risk factors for progression-free survival and overall survival were first scanned with chi-square tests and t -tests to compare patients who suffered from progression or death with who did not. Multivariate Cox regression was further utilized to identify independent risk factors. Results. Twenty-four adult patients (median age 32, range 16-73), with a male-to-female ratio of 1 : 1, was included from April 2010 to March 2020. After follow-up for 35.7 months (+/- months), seven patients died. With univariate analysis, higher C-reactive protein-to-albumin (CRP/Alb) ratio ( p = 0.028 ), higher baseline fibrinogen ( p = 0.006 ), and presence of distant metastasis ( p = 0.007 ) were associated with progression of the disease; higher preoperative fibrinogen ( p = 0.014 ) and distant metastasis ( p = 0.020 ) were associated with death. With multivariate Cox regression, only baseline fibrinogen level ( p = 0.001 ) was identified as an independent risk factor for progression-free survival; meanwhile, fibrinogen level ( p = 0.048 ) and distant metastasis ( p = 0.043 ) were identified as independent risk factors for survival. Conclusions. Overall, relatively high CRP/Alb ratios, fibrinogen, and distant metastasis were associated with a poor prognosis of Xp11.2 tRCC adult patients; among them, only baseline fibrinogen levels independently predicted the progression of Xp11.2 tRCC; thus, it may help to identify patients with worse progression or death risk.

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Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor of Disease-free Survival in Postnephrectomy High-risk Locoregional Renal Cell Carcinoma: Analysis of the S-TRAC Trial

Patel¹,

Ravaud

Motzer

et al. 2020

Clinical Cancer Research

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In the S-TRAC trial, adjuvant sunitinib improved disease-free survival (DFS) compared with placebo in patients with locoregional renal cell carcinoma (RCC) at high risk of recurrence. This post hoc exploratory analysis investigated the neutrophil-tolymphocyte ratio (NLR) for predictive and prognostic significance in the RCC adjuvant setting. Experimental Design: Kaplan-Meier estimates and Cox proportional analyses were performed on baseline NLR and change from baseline at week 4 to assess their association with DFS. Univariate P values were two-sided and based on an unstratified log-rank test. Results: 609 of 615 patients had baseline NLR values; 574 patients had baseline and week 4 values. Sunitinib-treated patients with baseline NLR <3 had longer DFS versus placebo (7.1 vs. 4.7; HR, 0.71; P ¼ 0.02). For baseline NLR ≥3, DFS was similar regardless of treatment (sunitinib 6.8 vs. placebo not reached; HR, 1.03; P ¼ 0.91). A ≥25% NLR decrease at week 4 was associated with longer DFS versus no change (6.8 vs. 5.3 years; HR, 0.71; P ¼ 0.01). A greater proportion of sunitinib-treated patients had ≥25% NLR decrease at week 4 (71.2%) versus placebo (17.4%). Patients with ≥25% NLR decrease at week 4 received a higher median cumulative sunitinib dose (10,137.5 mg) versus no change (8,168.8 mg) or ≥25% increase (6,712.5 mg). Conclusions: In the postnephrectomy high-risk RCC patient cohort, low baseline NLR may help identify those most suitable for adjuvant sunitinib. A ≥25% NLR decrease at week 4 may be an early indicator of those most likely to tolerate treatment and derive DFS benefit.

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Preoperative neutrophil-to-lymphocyte ratio predicts the surgical outcome of Xp11.2 translocation/TFE3 renal cell carcinoma patients

Cited by 15 publications

References 33 publications

Preoperative Plasma Fibrinogen: An Independent Predictor for Survival in Adult Patients with Xp11.2 Translocation Renal Cell Carcinoma

Preoperative Plasma Fibrinogen: An Independent Predictor for Survival in Adult Patients with Xp11.2 Translocation Renal Cell Carcinoma

Xp11.2 Translocation Renal Cell Carcinoma: Clinical Characteristics and Potential Prognostic Predictors

Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor of Disease-free Survival in Postnephrectomy High-risk Locoregional Renal Cell Carcinoma: Analysis of the S-TRAC Trial

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