Preoperative neutrophil–lymphocyte ratio correlated with glioma grading and glioblastoma survival

Abstract

The preoperative NLR was correlated with glioma grading, and the elevated NLR was an independent predictive factor for poor outcome of glioblastoma patients. Abbreviation IDH1: Isocitrate dehydrogenase 1IL-8: Interleukin-8KPS: Karnofsky Performance ScoresNLR: Neutrophil-lymphocyte ratioOS: Overall survivalROC: Receiver operating characteristicSD: Standard deviationsWHO: World Health Organization.

Prognostic Significance of Preoperative Systemic Cellular Inflammatory Markers in Gliomas: A Systematic Review and Meta‐Analysis

“…All of the included studies were published in recent years and were from seven different countries, which were retrospectively designed with 17 single‐center trialsand one multicenter trial . There were 15 studies performed multivariate Cox regression analysis and reported adjusted HR . The main features of the selected studies are shown in Table 1 .…”

“…In the analysis of the NLR for predicting the prognosis of gliomas, 15 studies ( n = 2,798 patients) were included. The patients with a higher pre‐operative NLR had a worse prognosis (HR: 1.38; 95% CI: 1.09–1.74; P = 0.008; Figure a ).…”

“…Systemic cellular inflammatory markers can be a noninvasive biomarker with relatively high sensitivity and specificity for glioma diagnosis . Moreover, the pre‐operative inflammatory response is correlated with glioma grading, which can be quantified as scores for predicting glioma survival after different therapeutic methods are used . In this study, we performed a meta‐analysis to evaluate the prognostic role of systemic cellular inflammatory markers (NLR, PLR, LMR, RDW, and PNI) in 3,261 patients with glioma from 18 studies.…”

“…In total, 3,261 patients diagnosed with glioma from 18 studies were included. 9,11,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] All of the included studies were published in recent years and were from seven different countries, which were retrospectively designed with 17 single-center trials 9,11,[18][19][20]22,[24][25][26][27][28][29][30][31][32][33][34] and one multicenter trial. 23 There were 15 studies performed multivariate Cox regression analysis and reported adjusted HR.…”

“…23 There were 15 studies performed multivariate Cox regression analysis and reported adjusted HR. 9,[18][19][20][22][23][24][25][26][27][28]30,31,33,34 The main features of the selected studies are shown in Table 1.…”