Preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios as independent predictors of cervical stromal involvement in surgically treated endometrioid adenocarcinoma

Wang, Dan; Yang, Jiaxin; Cao, Dongyan; Wan, Xi-Run; Feng, Fengzhi; Huang, Huifang; Shen, Keng; Xiang, Yang

doi:10.2147/ott.s41711

Cited by 67 publications

(44 citation statements)

References 19 publications

(24 reference statements)

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“…It was found that PLR has better prognostic value than platelet or lymphocytes alone in predicting certain cardiovascular diseases [23]. We found that PLR was significantly higher for patients who died within 30-days of hospital admission in the univariate analysis.…”

Section: Discussionmentioning

confidence: 61%

The values of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting 30 day mortality in patients with acute pulmonary embolism

Mao

et al. 2016

BMC Cardiovasc Disord

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BackgroundvAcute pulmonary embolism (PE) is a life threatening disease. The treatment options depend on the severity of the disease and the mortality varies widely depending on the severity of the condition. It is important to identify patients who are at high risk of mortality. The aim of the present study was to explore the prognostic alues of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) for 30-day mortality in patients with acute PE.MethodsThe study included 321 patients admitted to our university hospital between January 2013 and May 2015 with the diagnosis of acute PE. Multivariable risk models were developed to assess the predictive values of the NLR and PLR for 30-day mortality. Discrimination was evaluated using receiver operating characteristic (ROC) curves.ResultsTwo hundred forty-eight patients met our selection criteria. Twenty of them died within 30 days of hospital admission. NLR was found to be an independent predicator after other confounding factors were adjusted in the model. For 1 unit of increase of NLR, the risk of 30-day mortality rose about 13 % (OR = 1.13,95 % CI: 1.04–1.23). The area under ROC for NLR is 0.79 (95 %CI: 0.703–0.880). PLR was associated with 30-day mortality in univariate analysis but the predicative ability diminished with inclusion of other predicators in multivariable model.ConclusionsNLR is readily available predicator for short-term mortality. It could be a useful indicator for identifying high risk population and guiding clinical management of acute PE.

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Section: Discussionmentioning

confidence: 61%

The values of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting 30 day mortality in patients with acute pulmonary embolism

Mao

et al. 2016

BMC Cardiovasc Disord

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“…In the report by Suh et al, the cutoff value of NLR was 1.97 [29]. Regarding the prediction of cervical stromal invasion, in the report of Wang et al [16], the cutoff value was 2.01. The cutoff value in our study was 2.18, which is close to the previous report.…”

Section: Discussionmentioning

confidence: 99%

“…However, the evidence has not been confirmed due to the small number of cases. Another report suggested predictors of cervical stromal invasion in endometrial cancers [16]. However, there have been studies to assess whether inflammatory markers could be independent predictors of survival or LN metastasis.…”

Section: Introductionmentioning

confidence: 99%

Pretreatment Neutrophil-to-Lymphocyte Ratio Was a Predictor of Lymph Node Metastasis in Endometrial Cancer Patients

et al. 2019

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Objective: The pretreatment neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been reported to be useful as markers for prognostic factors and metastasis in several cancers. The aim of this study was to identify the predictor of lymph node (LN) metastasis by pretreatment NLR and PLR in patients with endometrial cancer. Methods: Medical charts of the patients with endometrial cancers that received primary surgery at our hospital between 2007 and 2013 were retrospectively analyzed. The cutoff value was calculated from the receiver operating characteristics (ROC) curve. Clinicopathological parameters including inflammatory markers were evaluated for LN metastasis using multiple logistic regression analysis. Results: Among 197 patients enrolled in the study, LN metastasis was observed in 25 patients (13%). ROC curves demonstrated that the best cutoff value of NLR for predicting LN metastasis was 2.18 and that of PLR was 206. In univariate analysis, several pathological factors, NLR, and PLR were identified as predictors of LN metastasis. In multiple logistic regression analysis, lymphovascular invasion and NLR were found to be significantly correlated with LN metastasis (p = 0.002, 0.039). Conclusion: A higher pretreatment NLR was identified as a predictor of LN metastasis in endometrial cancers. Although further study is needed to confirm the results, NLR could be a candidate clinical marker for detection of LN metastasis.

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“…In addition, a study revealed that even though there were no difference between platelet counts between EC and control groups, the mean platelet volume which is one of morphological parameters of platelet, is higher in EC group than normal control groups [ 14 ]. On the other hand, Wang et al [ 15 ] reported that NLR and PLR were found higher in patients with EC with cervical stromal invasion, and suggested the evaluation of these ratios may help select patients who should be particularly watched and tested for cervical stromal involvement.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-lymphocyte and platelet-lymphocyte ratios in endometrial hyperplasia

et al. 2015

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ObjectiveThe purpose of present study was to evaluate association between neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) and endometrial hyperplasia (EH).MethodsOne hundred and ten women with abnormal uterine bleeding were included into the study. Blood samples were drawn from all patients to obtain complete blood cell counts, neutrophil-leukocyte ratio and platelet-leukocyte ratio before endometrial curettage procedure initiated. The patients were divided into three groups due to their pathological results: group 1, patients with EH without atypia (n=40); group 2, patients with EH with atypia (n=15); and group 3, patients with neither hyperplasia nor cancer as control group (n=55). Blood cell counts, NLRs and PLRs were compared among these groups.ResultsBased on hemoglobin and platelet counts, there was no significant difference among these groups (P>0.05). Leukocyte and neutrophil counts were higher in group 2 (EH with atypia) than group 1 and group 3 (P<0.01). NLR of group 2 was significantly elevated when compared to group 1 and group 3 (P=0.004). PLR was higher in group 1 and group 2 than control group (P=0.024).ConclusionNon-specific inflammatory markers such as NLR and PLR were elevated in women with atypical EH. These markers may be used as a predictor of atypical EH in patients with abnormal uterine bleeding.

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Preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios as independent predictors of cervical stromal involvement in surgically treated endometrioid adenocarcinoma

Cited by 67 publications

References 19 publications

The values of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting 30 day mortality in patients with acute pulmonary embolism

The values of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting 30 day mortality in patients with acute pulmonary embolism

Pretreatment Neutrophil-to-Lymphocyte Ratio Was a Predictor of Lymph Node Metastasis in Endometrial Cancer Patients

Neutrophil-lymphocyte and platelet-lymphocyte ratios in endometrial hyperplasia

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