Preoperative MRI of breast squamous cell carcinoma: diagnostic value of distinguishing between two subtypes

Chen, S; Du, Yonghao; Hu, Yue; Ling, Rennan; Huang, Di; Xiang, Jialin; Liang, Yongquan; Wei, Xinhua; Tang, Wenjie; Guo, Yuan

doi:10.1016/j.crad.2021.12.018

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…According to the Breast Imaging Reporting and Data System Lexicon (BI-RADS), nonmass enhancement(NME) represents an area of contrast enhancement without a space-occupying effect and mass enhancement in three dimensional space has fat pushing effect ( 19 ). As for internal enhancement pattern, we mainly refer to the our previous study which defined rim enhancement: more pronounced contrast enhancement at the periphery of a tumor compared to that at the center and heterogeneous enhancement: with heterogeneous enhancement in the tumor ( 20 ).…”

Section: Methodsmentioning

confidence: 99%

Nomogram for the prediction of triple-negative breast cancer histological heterogeneity based on multiparameter MRI features: A preliminary study including metaplastic carcinoma and non- metaplastic carcinoma

et al. 2022

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ObjectivesTriple-negative breast cancer (TNBC) is a heterogeneous disease, and different histological subtypes of TNBC have different clinicopathological features and prognoses. Therefore, this study aimed to establish a nomogram model to predict the histological heterogeneity of TNBC: including Metaplastic Carcinoma (MC) and Non-Metaplastic Carcinoma (NMC).MethodsWe evaluated 117 patients who had pathologically confirmed TNBC between November 2016 and December 2020 and collected preoperative multiparameter MRI and clinicopathological data. The patients were randomly assigned to a training set and a validation set at a ratio of 3:1. Based on logistic regression analysis, we established a nomogram model to predict the histopathological subtype of TNBC. Nomogram performance was assessed with the area under the receiver operating characteristic curve (AUC), calibration curve and decision curve. According to the follow-up information, disease-free survival (DFS) survival curve was estimated using the Kaplan-Meier product-limit method.ResultsOf the 117 TNBC patients, 29 patients had TNBC-MC (age range, 29–65 years; median age, 48.0 years), and 88 had TNBC-NMC (age range, 28–88 years; median age, 44.5 years). Multivariate logistic regression analysis demonstrated that lesion type (p = 0.001) and internal enhancement pattern (p = 0.001) were significantly predictive of TNBC subtypes in the training set. The nomogram incorporating these variables showed excellent discrimination power with an AUC of 0.849 (95% CI: 0.750−0.949) in the training set and 0.819 (95% CI: 0.693−0.946) in the validation set. Up to the cutoff date for this analysis, a total of 66 patients were enrolled in the prognostic analysis. Six of 14 TNBC-MC patients experienced recurrence, while 7 of 52 TNBC-NMC patients experienced recurrence. The DFS of the two subtypes was significantly different (p=0.035).ConclusionsIn conclusion, we developed a nomogram consisting of lesion type and internal enhancement pattern, which showed good discrimination ability in predicting TNBC-MC and TNBC-NMC.

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Section: Methodsmentioning

confidence: 99%