Preoperative maximal voluntary ventilation, hemoglobin, albumin, lymphocytes and platelets predict postoperative survival in esophageal squamous cell carcinoma

Abstract

BACKGROUND Preoperative pulmonary function plays an important role in selecting surgical candidates and assessing postoperative complications. Reduced pulmonary function is associated with poor survival in several cancers, but the prognostic value of preoperative pulmonary function in esophageal squamous cell carcinoma (ESCC) is unclear. Nutritional and systemic inflammation parameters are vital to cancer survival, and the combination of these parameters improves the prognostic value. The hemoglobin, albumin, lymphocytes and platelets (HALP) score is a novel prognostic indicator to reflect the nutritional and inflammation status, but the clinical effects of the HALP score combined with maximal voluntary ventilation (MVV), an important parameter of pulmonary function, have not been well studied in ESCC. AIM To investigate the prognostic value of MVV and HALP score for assessing postoperative survival of ESCC patients. METHODS Data from 834 ESCC patients who underwent radical esophagectomy with R0 resection were collected and retrospectively analyzed. Preoperative MVV and HALP data were retrieved from medical archives. The HALP score was calculated by the formula: Hemoglobin (g/L) × albumin (g/L) × lymphocytes (/L)/platelets (/L). The optimal cut-off values of MVV and HALP score were calculated by the receiver operating characteristic curve analysis. The Kaplan-Meier method with log-rank test was used to draw the survival curves for the variables tested. Multivariate Cox proportional hazard regression models were used to analyze the independent prognostic factors for overall survival. RESULTS MVV was significantly associated with gender ( P < 0.001), age at diagnosis ( P < 0.001), smoking history ( P < 0.001), drinking history ( P < 0.001), tumor length ( P = 0.013), tumor location ( P = 0.037) and treatment type ( P = 0.001). The HALP score was notably associated with gender ( P < 0.001), age at diagnosis ( P = 0.035), tumor length ( P < 0.001) and invasion depth ( P = 0.001). Univariate Cox regression analysis showed that low MVV and low HALP score were associated with worse overall survival (all P < 0.001). Multivariate analysis showed that low MVV and the HALP score were both independent risk factors for overall survival (all P < 0.001). The combination of MVV and HALP score improved the prediction performance for overall survival than tumor-node-metastasis. Also, low combination of MVV and HALP score was an independent risk factor for poor overall survival ( P < 0.001). CONCLUSION MVV, HALP score and their co...

Distinguishing optimal esophagectomy candidates in elderly patients: A nomogram based on propensity score matching

“…Patients with higher Eastern Cooperative Oncology Group performance status score are less likely to receive surgery and have poorer outcomes. Serum albumin and the absolute lymphocyte count were also reported as important prognostic factor for patients [21,22]. However, these essential factors were not recorded in the SEER database.…”

Hemoglobin, albumin, lymphocytes and platelets (HALP) score is a useful predictor of survival in patients with recurrent glioblastoma multiforme treated with bevacizumab plus irinotecan

“…Chen et al rstly described this HALP score to predict the prognosis of gastric cancer. In 1332 patients with gastric cancer who underwent gastrectomy, the preoperative HALP ≥ 56.8 group had a signi cantly better prognosis than the HALP < 56.8 group [9]. Also, the prognostic effectiveness of the HALP score has been investigated in, esophageal squamous cell cancer [10], pancreatic cancer [11], colorectal cancer [12], renal cell carcinoma [13], bladder cancer [14], prostate cancer [15,16], and small cell lung cancer [17,18].…”

“…Hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been shown to be a new and potential prognostic indicator for various malignancies [8][9][10][11][12][13][14][15][16][17]. We aimed to investigate whether the HALP score is a predictive marker in patients with recurrent GBM who were given bevacizumab plus irinotecan.…”

The Importance of Systemic Inflammatory Response Index, Systemic Immune-Inflammation Index, and Hemoglobin-Albumin-Lymphocytes-Platelets (HALP) Score in Children with Cancer

“…The inflammatory biomarkers were calculated from complete blood count and biochemical analysis. The calculations were defined as follows: NLR: the ratio of neutrophil count to lymphocyte count, PLR: the ratio of platelet count to lymphocyte count, LMR: the ratio of lymphocyte count to monocyte count, SII index: platelet count × NLR, SIRI: [neutrophil count × monocyte count] / lymphocyte count, and HALP score: [Hemoglobin (g/L) × albumin (g/L) × lymphocyte count (/L)] / platelet count (/L) (15,16).…”