Preoperative lymphocyte-to-monocyte ratio versus platelet-to-lymphocyte ratio as a prognostic predictor for non-small cell lung cancer patients

Abstract

Summary Background We investigated the prognostic value of the preoperative lymphocyte-to-mononuclear ratio (LMR) and platelet-to-lymphocyte ratio (PLR) in a large cohort of patients with non-small cell lung cancer (NSCLC). Methods Clinical-pathological data from 507 NSCLC patients at Taizhou Hospital of Zhejiang Province between 2010 and 2016 were retrospectively evaluated. X-tile software was used to assess the optimal cutoff levels for LMR and PLR. Univariate and multivariate Cox regression models were used to assess the prognostic factors. Results The median follow-up duration after surgical resection was 34.5 months. Patients were stratified into 2 groups by LMR (2.6 and = 2.6) and PLR (179.6 and = 179.6). Our results revealed that lower LMR (HR = 3.163 (1.821–5.493), P = 0.000), age (HR = 2.252 (1.412–3.592), P = 0.001), T stage (HR = 3.749 (2.275–6.179), P = 0.000), N stage (HR = 3.106 (1.967–4.902), P = 0.000), and cut edge (HR = 3.830 (1.077–13.618), P = 0.038) were considered to be independent indicators for overall survival (OS) of NSCLC patients. For disease-free survival (DFS), age, sex, T stage, N stage, LMR and cut edge were verified to be independent prognostic factors in patients with NSCLC. Conclusions In the study cohort, reduced LMR was a robust independent predictor for both OS and DFS in patients with NSCLC who underwent surgical resection.

Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer

“… 36–38 There were also a number of clinical studies that investigated the prognostic significance of LMR, and the results confirmed that LMR was a significant prognostic predictor. 39 , 40 …”