Preoperative lymphocyte-to-monocyte ratio (LMR) could independently predict overall survival of resectable gastric cancer patients

Abstract

Preoperational hemogram parameters have been reported to be associated with the prognosis of several types of cancers. This study aimed to investigate the prognostic value of hematological parameters in gastric cancer in a Chinese population. A total of 870 gastric cancer patients who underwent radical tumorectomy were recruited from January 2008 to December 2012. Preoperative hematological parameters were recorded and dichotomized by time-dependent receiver operating characteristic curves. The survival curves of patients stratified by each hematological parameter were plotted by the Kaplan–Meier method and compared by log-rank test. Multivariate Cox proportional hazards models were used to select parameters independently correlated with prognosis. The median age of the patients was 60 years. The median follow-up time was 59.9 months, and the 5-year survival rate was 56.4%. Results from the univariate analyses showed that low lymphocyte count (<2.05 × 109/L), high neutrophil-to-white blood cell ratio (NWR > 0.55), low lymphocyte-to-white blood cell ratio (LWR < 0.23), low lymphocyte-to-monocyte ratio (LMR < 5.43), high neutrophil-to-lymphocyte ratio (NLR > 1.44), and high platelet-to-lymphocyte ratio (PLR > 115) were associated with poor survival of gastric cancer patients. Multivariate analysis showed that low LMR (HR: 1.49, 95% CI: 1.17–1.89, P = .001) was the only hematological factor independently predicting poor survival. These results indicate that preoperational LMR is an independent prognostic factor for patients with resectable gastric cancer.

Clinicopathological and prognostic significance of platelet-lymphocyte ratio (PLR) in gastric cancer: an updated meta-analysis

“…PLR in 44 cohorts with 26,901 GC patients were evaluated for OS [ 7 , 11 – 13 , 17 , 19 – 27 , 29 – 34 , 37 , 38 , 41 – 51 , 53 – 61 ]. The main results of this meta-analysis are listed in Table 2 .…”

Dynamic Changes in Pre- and Postoperative Levels of Inflammatory Markers and Their Effects on the Prognosis of Patients with Gastric Cancer

“…A series of studies have confirmed that pre-LMR, NLR, PLR, and SII are markers of SIR and are closely related to the survival of patients with GC. [24][25][26][27] However, researchers have not studied the changes in SIR levels in patients with GC before and after surgery and their effects on the prognosis. Previous studies have confirmed that the resection margin (R-status) is an independent predictor of OS in patients with GC.…”

The benefits of higher LMR for early threatened abortion: A retrospective cohort study

“…It was the first study to evaluate the relationship of LMR and miscarriage in women with early threatened abortion. Nevertheless, the PLOS ONE bulk of literature have described that the higher LMR was a negative factor for the prognosis of diseases, such as gastric cancer [30] and early-stage Hodgkin lymphoma [31]. But a meta analysis study has suggested that the low LMR was associated with the poor outcome for patients with esophageal squamous cell carcinoma [32].…”