Preoperative lymphocyte/C-reactive protein ratio and its correlation with CD8+ tumor-infiltrating lymphocytes as a predictor of prognosis after resection of intrahepatic cholangiocarcinoma

Miyazaki, Katsuki; Morine, Yuji; Imura, Satoru; Ikemoto, Tetsuya; Saito, Yu; Yamada, Shinichiro; Tokuda, Kazunori; Okikawa, Shohei; Yamashita, Shoko; Oya, Takeshi; Tsuneyama, Koichi

doi:10.1007/s00595-021-02295-5

Cited by 13 publications

(7 citation statements)

References 44 publications

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“…Authors studied pre-operative CLR values of the subjects with oral squamous cell carcinoma and concluded that CLR was associated with better prognostic performance compared to other inflammatory markers and elevated CLR levels indicated poor overall and disease-free survival in this population 16 18 . Moreover, prognostic value of elevated CLR has been also shown in patients with lung cancer 19 , osteosarcoma 20 , and cholangiocarcinoma 21 . It is a fact that malignant conditions are associated with increased inflammatory burden 22 , as seen in patients with COVID-19 infection.…”

Section: Discussionmentioning

confidence: 96%

La proporción de proteína C reactiva a linfocitoE es un marcador confiable en pacientes con infección por COVID-19; el estudio CLEAR COVID

Demirkol¹,

Bilgin²,

Kahveci³

et al. 2022

CIRU

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Objective: COVID-19 infection is characterized with elevation of inflammatory markers in bloodstream. A novel inflammatory marker, C-reactive protein (CRP)-to-lymphocyte ratio (CLR), is suggested to be associated with inflammation. We aimed to compare the CLR values of the deceased COVID-19 patients to the CLR of survived subjects. Materials and Methods: The patients with COVID-19 whom presented to outpatient or inpatient clinics of AbantIzzet Baysal University Hospital were enrolled to the present retrospective study. Subjects were grouped as either deceased or survived. CLR values of the groups were compared. Results: Study cohort was consisted of 568 subjects in deceased and 4753 patients in survived group. Median CLR of the deceased and survived groups were 90 (0.2-1679)% and 11 (0.2-1062)%, respectively (p < 0.001). The sensitivity (75%) and specificity (70%) of CLR (> 23.4% level) in detecting mortality were higher than those of CRP and ferritin (AUC: 0.80, p < 0.001, 95% CI: 0.78-0.82). Conclusion: We suggest that elevated CLR levels in COVID-19 patients on admission should alert physicians for poor outcome.

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Section: Discussionmentioning

confidence: 96%

La proporción de proteína C reactiva a linfocitoE es un marcador confiable en pacientes con infección por COVID-19; el estudio CLEAR COVID

Demirkol¹,

Bilgin²,

Kahveci³

et al. 2022

CIRU

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“…Moreover, elevated CLR levels have been shown in subjects with pancreatic cancer 13 . In a recent report, it has been found that CLR was increased in subjects with cholangiocarcinoma 14 . Not only malignant conditions but also other inflammatory diseases are associated with elevated CLR.…”

Section: Discussionmentioning

confidence: 97%

“…that CLR was increased in subjects with cholangiocarcinoma. 14 Not only malignant conditions but also other inflammatory diseases are associated with elevated CLR. Patients with intestinal ischemia have increased CLR values compared to controls.…”

Section: The Association Between Inflammation and Clr Has Been Reportedmentioning

confidence: 99%

C‐reactive protein to LymphocytE count ratio could be a reliable mArkeR of thyroiditis; the CLEAR‐T study

Demirkol

Aktas

2022

Precision Medical Sciences

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Inflammation of the thyroid gland is referred to as thyroiditis and is associated with inflammation. Recent studies found significant association between thyroiditis and novel inflammatory and metabolic markers, as well as C‐reactive protein (CRP). CRP/lymphocyte count ratio (CLR) is a novel inflammatory marker that associated with various conditions and has not been studied in thyroiditis, yet. We aimed to investigate CRP to lymphocyte count ratio in patients with thyroiditis and to compare to those in healthy subjects. Patients with thyroiditis that presented to internal medicine outpatient clinics of our institution between January 2019 and August 2021 were enrolled to the retrospective study. Healthy volunteers were enrolled as control group. CLR of the thyroiditis and control groups were compared. Median CLR of the thyroiditis and control groups were 3.14 (0.14%–38)% and 0.4 (0.03–8.86)%, respectively (p < .001). The sensitivity and specificity of CLR > 0.43% in detecting thyroiditis were 92% and 58%, respectively (AUC: 0.88, p < .001, 95% CI: 0.85–0.92).CLR was significantly and positively correlated with free T4 (FT4) (r = .18, p < .001) and inversely correlated with thyroid stimulating hormone (TSH) (r = −.52, p = .003) levels. In conclusion, we suggest that high CLR levels may yield additional diagnostic value in patients with thyroiditis.

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“…Subsequently, Mungan et al 13 confirmed the results of Meng et al 12 . In addition, prognostic value of elevated CLR has also been shown in patients with osteosarcoma 14 , cholangiocarcinoma 15 , and lung cancer 16 . It is a fact that malignant conditions are associated with increased inflammatory burden 17 , as seen in patients with CHC.…”

Section: Discussionmentioning

confidence: 98%

C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

Demirkol

Aktas

Bilgin

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: Chronic hepatitis C (CHC) is one of the most important health problems affecting the significant rate of world population and it may lead to cirrhosis and hepatocellular carcinoma. C-reactive protein to lymphocyte count ratio (CLR) is used in estimating inflammatory burden. Therefore, this study aimed to compare CLR values between CHC patients and healthy controls and between CHC patients with and without fibrosis. METHODS: Patients with CHC infection who visited outpatient and inpatient internal medicine clinics of our institution between January 2021 and December 2021 were enrolled to this retrospective study. CLR of the patients with CHC and healthy controls were compared. We further compared CLR of CHC patients with and without fibrosis. RESULTS: Median CLR of CHC and control subjects was 2.61 (5.13%) and 0.31 (0.37%), respectively. CLR of the CHC group was significantly increased compared to the CLR of the controls (p<0.001). There was a significant positive correlation between CLR and APRI score (r=0.15, p=0.04). The sensitivity and specificity of CLR in determining CHC above 0.58% level were 84% and 82%, respectively (AUC: 0.884, p<0.001, 95%CI 0.84-0.93). In subgroup analysis, CLR was 3.97 (6.6%) for CHC patients with fibrosis and 1.7 (4.4%) for CHC subjects without fibrosis (p=0.001). CONCLUSIONS: Increased CLR in patients with CHC may be an alarming finding of liver fibrosis, as CLR is associated with both CHC and hepatic fibrosis.

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Preoperative lymphocyte/C-reactive protein ratio and its correlation with CD8+ tumor-infiltrating lymphocytes as a predictor of prognosis after resection of intrahepatic cholangiocarcinoma

Cited by 13 publications

References 44 publications

La proporción de proteína C reactiva a linfocitoE es un marcador confiable en pacientes con infección por COVID-19; el estudio CLEAR COVID

La proporción de proteína C reactiva a linfocitoE es un marcador confiable en pacientes con infección por COVID-19; el estudio CLEAR COVID

C‐reactive protein to LymphocytE count ratio could be a reliable mArkeR of thyroiditis; the CLEAR‐T study

C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

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