Preoperative Localization of Gastrointestinal Endocrine Tumors Using Somatostatin-Receptor Scintigraphy

Abstract

The data from this small series suggest that SRS is helpful in the preoperative localization of gastrointestinal endocrine tumors.

Intraoperative localization of gut endocrine tumors with radiolabeled somatostatin analogs and a gamma-detecting probe

“…Successful tumor localization has been achieved with a sensitivity ranging from 72% to 90%, a specificity of 100%, and an overall accuracy of 82% in patients with carcinoid tumor and gastrinoma. Previously unrecognized metastases were also detected [3,6,7,14].…”

“…Octreotide scans appear particularly useful for imaging gut neuroendocrine tumors [5,6]. The density of cell membrane-bound somatostatin receptors in gastro-enteropancreatic endocrine tumors is often much greater than that found in normal tissue and this facilitates radionuclide labeling and scintigraphic imaging of tumors.…”

“…The density of cell membrane-bound somatostatin receptors in gastro-enteropancreatic endocrine tumors is often much greater than that found in normal tissue and this facilitates radionuclide labeling and scintigraphic imaging of tumors. Octreotide scan has been reported to detect more than 90% of gastrinomas and carcinoid tumors [6,7]. Intraoperatively, however, it may be difficult to identify precisely the site of a small somatostatin-receptor-bearing tumor on the basis of the ill-defined anatomical localization obtained by octreotide scintigraphy.…”

Spezielle diagnostische und therapeutische Aspekte beim Insulinom

“…Ursache hierfü r ist die Tatsache, daß Insulinome meist sehr klein sind mit einem Tumordurchmesser von 0,5-2 cm und sich damit hä ufig der bildgebenden Darstellung entziehen. Dies hat zur Folge, daß die Bildgebung auch unter Einsatz verschiedener diagnostischer Verfahren wenig sensitiv ist [5,17,19,21,25]. Demgegenü ber ist die chirurgische Exploration in ü ber 90 % der Fä lle erfolgreich, so daß in den vergangenen Jahren die Mehrzahl endokrin chirurgischer Zentren auf prä operative Bildgebung verzichtet hat [2,3,24].…”

Early massive accumulation of In-111 pentetreotide in a metastatic liver tumor of islet cell carcinoma

“…Similar results from other institutes have followed. [6][7][8][9][10][11][12][13][14] These articles describe the agent as sensitive especially for neuroendocrine gastro-enteropancreatic tumors and the scintigraphy often detects unknown lesions missed by other conventional methods 8.10,15 The optimal time for imaging of the scintigraphy has been discussed. Many articles recommend late imaging because of high background in the early stages of imaging.…”