Preoperative local staging of endometrial cancer: the challenge of imaging techniques and serum biomarkers

Abstract

Our results, even the low number of enrolled patients, are promising and may lead to a greater efficiency and lower health care costs in identifying those women who require radical surgery and pelvic lymphadenectomy and should be addressed, in specialized centers.

Diagnostic Performance of Transvaginal Ultrasound for Detecting Cervical Invasion In Women With Endometrial Carcinoma: A Systematic Review and Meta‐analysis

“…Seventeen studies published between 1994 and 2016 reporting on 1751 patients were included in the final analyses. Among these 1751 women, 288 had cervical invasion.…”

“…The study design was clearly stated as prospective in 11 studies . The Quality Assessment of Diagnostic Accuracy Studies 2 assessment of the risk of bias and concerns regarding applicability of the selected studies is shown graphically in Figure .…”

“…With regard to the risk of bias about the patient selection domain, 1 study was not clear regarding patient inclusion criteria, and 7 were considered high risk (1 study because the pathologic analysis was done after radiation in a group of patients included, 2 because they included women with a preoperative diagnosis of endometrial hyperplasia with atypia, and 4 because only patients with “conclusive” or “unequivocal” TVUS results were included) . Concerning the index test domain, 10 studies adequately described the method of the index text as well as how it was performed and interpreted . However, 6 studies were considered high risk, since the examiner estimated cervical invasion “subjectively,” or the criteria used were not described .…”

Clinical Value of 3‐Dimensional Ultrasound in Gynecology

“…The diagnosis of endometrial neoplasia is made possible with 3D TVUS, even when circumstances do not allow histologic sampling of the endometrium because of cervical stenosis, which may occur. Additionally, it is reasonable to compare the accuracy and cost‐efficiency of the use of US versus MRI for this purpose . Figure shows a US illustration of a case of endometrial carcinoma.…”

“…Additionally, it is reasonable to compare the accuracy and costefficiency of the use of US versus MRI for this purpose. [12][13][14] Figure 9 shows a US illustration of a case of endometrial carcinoma.…”